PMID- 38284779
OWN - NLM
STAT- Publisher
LR  - 20240129
IS  - 1745-7262 (Electronic)
IS  - 1008-682X (Linking)
DP  - 2024 Jan 26
TI  - A prospective cohort of men with localized prostate cancer on active surveillance 
      protocol in Hong Kong, China: what did we learn?
LID - 10.4103/aja202373 [doi]
AB  - This study aimed to report the outcomes of active surveillance (AS) in the 
      management of low-risk prostate cancer (PCa). It recruited 87 men who were 
      prospectively followed up according to the Prostate Cancer Research International 
      Active Surveillance (PRIAS) protocol with local adaptation at SH Ho Urology 
      Centre, Prince of Wales Hospital, Hong Kong, China. We investigated the 
      predictors of disease progression and found that baseline prostate-specific 
      antigen density (PSAD) and the presence of the highest Prostate Imaging-Reporting 
      and Data System (PI-RADS) score 5 lesion on magnetic resonance imaging (MRI) are 
      significantly correlated with disease progression. Moreover, men with PSAD >0.2 
      ng ml-2 or PI-RADS 4 or 5 lesions had significantly worse upgrading-free survival 
      compared to those with PSAD </=0.2 ng ml-2 and PI-RADS 2 or 3 lesions. The study 
      concludes that AS is a safe and effective management strategy for selected 
      patients to defer radical treatment and that most disease progression can be 
      detected after the first repeated biopsy. The combination of PSAD >0.2 ng ml-2 
      and PI-RADS 4 or 5 lesions may serve as a useful predictor of early disease 
      progression and provide a guide to optimize follow-up protocols for men in 
      different risk groups.
CI  - Copyright (c) 2024 Copyright: (c) The Author(s)(2024).
FAU - Wu, Xiaobo
AU  - Wu X
AD  - SH Ho Urology Centre, Department of Surgery, Faculty of Medicine, The Chinese 
      University of Hong Kong, Hong Kong, China.
FAU - Ko, Ivan Ching-Ho
AU  - Ko IC
FAU - Hong, Cindy Yeuk-Lam
AU  - Hong CY
FAU - Yee, Samuel Chi-Hang
AU  - Yee SC
FAU - Teoh, Jeremy Yuen-Chun
AU  - Teoh JY
FAU - Chan, Samson Yun-Sang
AU  - Chan SY
FAU - Tam, Ho-Man
AU  - Tam HM
FAU - Chan, Chi-Kwok
AU  - Chan CK
FAU - Ng, Chi-Fai
AU  - Ng CF
FAU - Chiu, Peter Ka-Fung
AU  - Chiu PK
LA  - eng
PT  - Journal Article
DEP - 20240126
PL  - China
TA  - Asian J Androl
JT  - Asian journal of andrology
JID - 100942132
SB  - IM
EDAT- 2024/01/29 12:43
MHDA- 2024/01/29 12:43
CRDT- 2024/01/29 09:14
PHST- 2023/07/16 00:00 [received]
PHST- 2023/11/21 00:00 [accepted]
PHST- 2024/01/29 12:43 [medline]
PHST- 2024/01/29 12:43 [pubmed]
PHST- 2024/01/29 09:14 [entrez]
AID - 00129336-990000000-00158 [pii]
AID - 10.4103/aja202373 [doi]
PST - aheadofprint
SO  - Asian J Androl. 2024 Jan 26. doi: 10.4103/aja202373.