PMID- 38285765
OWN - NLM
STAT- MEDLINE
DCOM- 20240131
LR  - 20240306
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Print)
IS  - 1513-7368 (Linking)
VI  - 25
IP  - 1
DP  - 2024 Jan 1
TI  - Current State of Knowledge on Blood and Tissue-Based Biomarkers for Opisthorchis 
      viverrini-induced Cholangiocarcinoma: A Review of Prognostic, Predictive, and 
      Diagnostic Markers.
PG  - 25-41
LID - 90975 [pii]
LID - 10.31557/APJCP.2024.25.1.25 [doi]
AB  - Cholangiocarcinoma (CCA) is a prevalent cancer in Southeast Asia, with 
      Opisthorchis viverrini (O.viverrini) infection being the primary risk factor. 
      Most CCA cases in this region are diagnosed at advanced stages, leading to 
      unfavorable prognoses. The development of stage-specific biomarkers for 
      Opisthorchis viverrini-induced cholangiocarcinoma (Ov-CCA) holds crucial 
      significance, as it facilitates early detection and timely administration of 
      curative interventions, effectively mitigating the high morbidity and mortality 
      rates associated with this disease in the Great Mekong region. Biomarkers are a 
      promising approach for early detection, prognosis, and targeted treatment of CCA. 
      Disease-specific biomarkers facilitate early detection and enable monitoring of 
      therapy effectiveness, allowing for any necessary corrections. This review 
      provides an overview of the potential O. viverrini-specific molecular biomarkers 
      and important markers for diagnosing and monitoring Ov-CCA, discussing their 
      prognostic, predictive, and diagnostic value. Despite the limited research in 
      this domain, several potential biomarkers have been identified, encompassing both 
      worm-induced and host-induced factors. This review offers a thorough examination 
      of historical and contemporary progress in identifying biomarkers through 
      multiomics techniques, along with their potential implications for early 
      detection and treatment.
FAU - Kafle, Alok
AU  - Kafle A
AUID- ORCID: 0000-0002-0048-5699
AD  - Tropical Medicine Graduate Program, Department of Tropical Medicine, Faculty of 
      Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
FAU - Suttiprapa, Sutas
AU  - Suttiprapa S
AUID- ORCID: 0000-0002-2323-2344
AD  - Tropical Medicine Graduate Program, Department of Tropical Medicine, Faculty of 
      Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
AD  - Tropical Disease Research Center, WHO Collaborating Centre for Research and 
      Control of Opisthorchiasis, Khon Kaen University, Khon Kaen 40002, Thailand.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240101
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - *Opisthorchis
MH  - Prognosis
MH  - *Cholangiocarcinoma/etiology/complications
MH  - *Opisthorchiasis/complications/diagnosis
MH  - Biomarkers
MH  - Bile Ducts, Intrahepatic/pathology
MH  - *Bile Duct Neoplasms/etiology/complications
PMC - PMC10911713
OTO - NOTNLM
OT  - Biological Markers
OT  - Keywords: cholangiocarcinoma
OT  - Opisthorchiasis
OT  - immunoassay
OT  - proteomics
EDAT- 2024/01/29 19:56
MHDA- 2024/01/31 06:43
PMCR- 2024/03/01
CRDT- 2024/01/29 14:12
PHST- 2023/09/04 00:00 [received]
PHST- 2024/01/31 06:43 [medline]
PHST- 2024/01/29 19:56 [pubmed]
PHST- 2024/01/29 14:12 [entrez]
PHST- 2024/03/01 00:00 [pmc-release]
AID - 90975 [pii]
AID - 10.31557/APJCP.2024.25.1.25 [doi]
PST - epublish
SO  - Asian Pac J Cancer Prev. 2024 Jan 1;25(1):25-41. doi: 
      10.31557/APJCP.2024.25.1.25.