PMID- 38286670
OWN - NLM
STAT- MEDLINE
DCOM- 20240404
LR  - 20240404
IS  - 2198-3844 (Electronic)
IS  - 2198-3844 (Linking)
VI  - 11
IP  - 13
DP  - 2024 Apr
TI  - Dynamics of The Gammadeltatcr Repertoires During The Dedifferentiation Process and Pilot 
      Implications for Immunotherapy of Thyroid Cancer.
PG  - e2306364
LID - 10.1002/advs.202306364 [doi]
LID - 2306364
AB  - gammadelta T cells are evolutionarily conserved T lymphocytes that manifest unique 
      antitumor efficacy independent of tumor mutation burden (TMB) and conventional 
      human leukocyte antigen (HLA) recognition. However, the dynamic changes in their 
      T cell receptor (TCR) repertoire during cancer progression and treatment courses 
      remain unclear. Here, a comprehensive characterization of gammadeltaTCR repertoires are 
      performed in thyroid cancers with divergent differentiation states through 
      cross-sectional studies. The findings revealed a significant correlation between 
      the differentiation states and TCR repertoire diversity. Notably, highly expanded 
      clones are prominently enriched in gammadelta T cell compartment of dedifferentiated 
      patients. Moreover, by longitudinal investigations of the gammadelta T cell response to 
      various antitumor therapies, it is found that the emergence and expansion of the 
      Vdelta2(neg) subset may be potentially associated with favorable clinical outcomes 
      after post-radiotherapeutic immunotherapy. These findings are further validated 
      at single-cell resolution in both advanced thyroid cancer patients and a murine 
      model, underlining the importance of further investigations into the role of 
      gammadeltaTCR in cancer immunity and therapeutic strategies.
CI  - (c) 2024 The Authors. Advanced Science published by Wiley-VCH GmbH.
FAU - Hao, Qing
AU  - Hao Q
AD  - Department of Laboratory Medicine, West China Hospital, Sichuan University, 
      Chengdu, Sichuan, 610041, China.
AD  - State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, 
      Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, 610041, 
      China.
FAU - Li, Ruicen
AU  - Li R
AD  - Health Promotion Center, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
FAU - Li, Hancong
AU  - Li H
AD  - Division of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
AD  - Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for 
      Disease-Related Molecular Network, Chengdu, 610041, China.
AD  - Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
FAU - Rui, Shu
AU  - Rui S
AD  - Division of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
AD  - Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for 
      Disease-Related Molecular Network, Chengdu, 610041, China.
AD  - Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
FAU - You, Liting
AU  - You L
AD  - Department of Laboratory Medicine, West China Hospital, Sichuan University, 
      Chengdu, Sichuan, 610041, China.
FAU - Zhang, Lingyun
AU  - Zhang L
AD  - School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong 
      SAR, 999077, China.
FAU - Zhao, Yue
AU  - Zhao Y
AD  - Division of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
AD  - Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for 
      Disease-Related Molecular Network, Chengdu, 610041, China.
AD  - Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
FAU - Li, Peiheng
AU  - Li P
AD  - Division of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
AD  - Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for 
      Disease-Related Molecular Network, Chengdu, 610041, China.
AD  - Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
FAU - Li, Yuanmin
AU  - Li Y
AD  - Division of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
AD  - Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for 
      Disease-Related Molecular Network, Chengdu, 610041, China.
AD  - Key Laboratory of Transplant Engineering and Immunology, Frontiers Science Center 
      for Disease Related Molecular Network, West China Hospital, Sichuan University, 
      Chengdu, 610041, China.
FAU - Kong, Xinagyu
AU  - Kong X
AD  - Division of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
AD  - Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for 
      Disease-Related Molecular Network, Chengdu, 610041, China.
AD  - Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
FAU - Chen, Haining
AU  - Chen H
AD  - Colorectal Cancer Center, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
FAU - Zou, Xiuhe
AU  - Zou X
AD  - Division of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
AD  - Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for 
      Disease-Related Molecular Network, Chengdu, 610041, China.
AD  - Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
FAU - Liu, Feng
AU  - Liu F
AD  - Division of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
AD  - Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for 
      Disease-Related Molecular Network, Chengdu, 610041, China.
AD  - Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
FAU - Wang, Xiaofei
AU  - Wang X
AD  - Division of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
AD  - Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for 
      Disease-Related Molecular Network, Chengdu, 610041, China.
AD  - Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
FAU - Zhou, Juan
AU  - Zhou J
AD  - Department of Laboratory Medicine, West China Hospital, Sichuan University, 
      Chengdu, Sichuan, 610041, China.
FAU - Zhang, Weihan
AU  - Zhang W
AD  - Gastric Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 
      610041, China.
FAU - Huang, Libing
AU  - Huang L
AD  - Division of Gastrointestinal Surgery, State Key Laboratory of Biotherapy, West 
      China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
FAU - Shu, Yang
AU  - Shu Y
AD  - Gastric Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 
      610041, China.
FAU - Liu, JiaYe
AU  - Liu J
AD  - Division of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
AD  - Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for 
      Disease-Related Molecular Network, Chengdu, 610041, China.
AD  - Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
FAU - Sun, Ronghao
AU  - Sun R
AD  - Department of Head and Neck Surgery, Sichuan Cancer Hospital, Sichuan Cancer 
      Institute, Sichuan Cancer Prevention and Treatment Center, Cancer Hospital of 
      University of Electronic Science and Technology School of Medicine, Chengdu, 
      610041, China.
FAU - Li, Chao
AU  - Li C
AD  - Department of Head and Neck Surgery, Sichuan Cancer Hospital, Sichuan Cancer 
      Institute, Sichuan Cancer Prevention and Treatment Center, Cancer Hospital of 
      University of Electronic Science and Technology School of Medicine, Chengdu, 
      610041, China.
FAU - Zhu, Jingqiang
AU  - Zhu J
AD  - Division of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
AD  - Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for 
      Disease-Related Molecular Network, Chengdu, 610041, China.
AD  - Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
FAU - Jiang, Yong
AU  - Jiang Y
AD  - Division of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan, 
      610041, China.
FAU - Wei, Tao
AU  - Wei T
AD  - Division of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
AD  - Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for 
      Disease-Related Molecular Network, Chengdu, 610041, China.
AD  - Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
FAU - Qian, Kun
AU  - Qian K
AD  - State Key Laboratory of Systems Medicine for Cancer, School of Biomedical 
      Engineering, Institute of Medical Robotics and Med-X Research Institute, Shanghai 
      Jiao Tong University, Shanghai, 200230, China.
FAU - Bai, Bing
AU  - Bai B
AD  - State Key Laboratory of Primate Biomedical Research, Institute of Primate 
      Translational Medicine, Kunming University of Science and Technology, Yunnan Key 
      Laboratory of Primate Biomedical Research, Kunming, Yunnan, 650500, China.
FAU - Hu, Yiguo
AU  - Hu Y
AD  - State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, 
      Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, 610041, 
      China.
AD  - Division of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
AD  - Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for 
      Disease-Related Molecular Network, Chengdu, 610041, China.
FAU - Peng, Yong
AU  - Peng Y
AD  - State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, 
      Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, 610041, 
      China.
FAU - Dai, Lunzhi
AU  - Dai L
AD  - State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, 
      Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, 610041, 
      China.
FAU - Caulin, Carlos
AU  - Caulin C
AD  - Department of Otolaryngology - Head & Neck Surgery and University of Arizona 
      Cancer Center, University of Arizona, Tucson, AZ, 85721, USA.
FAU - Xu, Heng
AU  - Xu H
AD  - Department of Laboratory Medicine, West China Hospital, Sichuan University, 
      Chengdu, Sichuan, 610041, China.
AD  - State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, 
      Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, 610041, 
      China.
FAU - Li, Zhihui
AU  - Li Z
AD  - Division of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
AD  - Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for 
      Disease-Related Molecular Network, Chengdu, 610041, China.
AD  - Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
FAU - Park, Jihwan
AU  - Park J
AUID- ORCID: 0000-0002-5728-912X
AD  - School of Life Sciences, Gwangju Institute of Science and Technology (GIST), 
      Gwangju, 61005, Republic of Korea.
FAU - Luo, Han
AU  - Luo H
AUID- ORCID: 0000-0002-9674-0139
AD  - Department of Laboratory Medicine, West China Hospital, Sichuan University, 
      Chengdu, Sichuan, 610041, China.
AD  - Division of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
AD  - Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for 
      Disease-Related Molecular Network, Chengdu, 610041, China.
AD  - Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, 610041, China.
AD  - Sichuan Clinical Research Center for laboratory medicine, Chengdu, Sichuan, 
      610041, China.
FAU - Ying, Binwu
AU  - Ying B
AD  - Department of Laboratory Medicine, West China Hospital, Sichuan University, 
      Chengdu, Sichuan, 610041, China.
AD  - Sichuan Clinical Research Center for laboratory medicine, Chengdu, Sichuan, 
      610041, China.
LA  - eng
GR  - 2021YFA1301203/National Key Research Development Program of China/
GR  - 82103031/National Natural Science Foundation of China/
GR  - 82272933/National Natural Science Foundation of China/
GR  - 2022NSFSC1314/Natural Science Foundation of Sichuan/
GR  - 22HXFH019/Clinical Research Incubation Project, West China Hospital, Sichuan 
      University/
GR  - ZYJC21033/1.3.5 Project for Disciplines of Excellence, West China Hospital, 
      Sichuan University/
GR  - ZYJC18004/1.3.5 Project for Disciplines of Excellence, West China Hospital, 
      Sichuan University/
GR  - 2021HXBH054/Post-Doctor Research Project, West China Hospital, Sichuan 
      University/
GR  - 2023NSFSC1851/Natural Science Foundation of Sichuan Province/
GR  - 2023M732446/Postdoctoral Research Foundation of China/
GR  - 2023YFS0098/Sichuan Science and Technology Program/
GR  - 2023YFS0113/Sichuan Science and Technology Program/
PT  - Journal Article
DEP - 20240129
PL  - Germany
TA  - Adv Sci (Weinh)
JT  - Advanced science (Weinheim, Baden-Wurttemberg, Germany)
JID - 101664569
RN  - 0 (Receptors, Antigen, T-Cell, gamma-delta)
SB  - IM
MH  - Humans
MH  - Mice
MH  - Animals
MH  - Receptors, Antigen, T-Cell, gamma-delta/genetics
MH  - Cross-Sectional Studies
MH  - Immunotherapy
MH  - *Thyroid Neoplasms/therapy
MH  - *Intraepithelial Lymphocytes
PMC - PMC10987121
OTO - NOTNLM
OT  - dedifferentiation
OT  - immunotherapy
OT  - single-cell
OT  - thyroid cancer
OT  - gammadelta T-cells
COIS- The authors declare no conflict of interest.
EDAT- 2024/01/30 00:42
MHDA- 2024/04/04 06:45
PMCR- 2024/01/29
CRDT- 2024/01/29 21:39
PHST- 2023/12/29 00:00 [revised]
PHST- 2023/09/04 00:00 [received]
PHST- 2024/04/04 06:45 [medline]
PHST- 2024/01/30 00:42 [pubmed]
PHST- 2024/01/29 21:39 [entrez]
PHST- 2024/01/29 00:00 [pmc-release]
AID - ADVS7362 [pii]
AID - 10.1002/advs.202306364 [doi]
PST - ppublish
SO  - Adv Sci (Weinh). 2024 Apr;11(13):e2306364. doi: 10.1002/advs.202306364. Epub 2024 
      Jan 29.