PMID- 38287753
OWN - NLM
STAT- MEDLINE
DCOM- 20240131
LR  - 20240206
IS  - 0300-5283 (Print)
IS  - 0300-5283 (Linking)
VI  - 79
IP  - 1
DP  - 2024 Jan
TI  - Correlation between impulse oscillometry with bronchodilator reversibility in 
      asthmatic population in a tertiary referral centre.
PG  - 21-27
AB  - INTRODUCTION: Spirometry is considered as a 'gold standard' for diagnosis of 
      asthma. Impulse oscillometry (IOS) is an alternative diagnostic tool which 
      requires less cooperation by the participants. We performed a study to determine 
      the correlation of IOS with bronchodilator reversibility from spirometry in 
      asthmatic participants. We studied the correlation between forced expiratory flow 
      (FEF(25%-75%)) and differences between the resistance at 5Hz and 20Hz 
      (R(5)-R(20)) in small airway disease (SAD) and the proportion of SAD diagnosed 
      using IOS. MATERIALS AND METHODS: This was a cross-sectional study involving 82 
      asthmatic participants in Hospital Canselor Tuanku Muhriz (HCTM), Universiti 
      Kebangsaan Malaysia (UKM) conducted between December 2020 till January 2022. 
      Participants performed pre- and post-bronchodilator IOS and spirometry within the 
      same day. Correlation between spirometry and IOS parameters and FEF(25%-75%) with 
      IOS were determined and analysed. RESULTS: The change of forced expiratory volume 
      in 1 second (FEV1) was statistically correlated with a change of R5 in IOS. A 
      decrement of 14.5% in R5 can be correlated with positive bronchodilator response 
      (BDR) with a sensitivity of 63.9% and specificity of 60.9%, p=0.007. 
      Pre-bronchodilator FEF(25%-75%) correlated with all parameters of SAD in IOS, 
      e.g., R(5)-R(20), reactance at 5Hz (X5) and area of reactance (AX), p < 0.05. IOS 
      detection for SAD is higher compared to FEF(25%-75%) in the BDR negative group 
      (91.3% vs 58.7%). CONCLUSION: IOS detected both bronchodilator reversibility and 
      SAD hence can be considered as an alternative tool to spirometry for diagnosis of 
      asthma in adults. IOS detected SAD more than FEF(25%-75%), especially in 
      BDR-negative group.
FAU - Mas Fazlin, M J
AU  - Mas Fazlin MJ
AD  - Universiti Kebangsaan Malaysia, Faculty of Medicine, Respiratory Unit, Kuala 
      Lumpur, Malaysia.
FAU - Ching, Z H
AU  - Ching ZH
AD  - Universiti Kebangsaan Malaysia, Faculty of Medicine, Respiratory Unit, Kuala 
      Lumpur, Malaysia.
FAU - Azat, A A
AU  - Azat AA
AD  - Universiti Kebangsaan Malaysia, Faculty of Medicine, Respiratory Unit, Kuala 
      Lumpur, Malaysia.
FAU - Mohamed Faisal, A H
AU  - Mohamed Faisal AH
AD  - Universiti Kebangsaan Malaysia, Faculty of Medicine, Respiratory Unit, Kuala 
      Lumpur, Malaysia. faisal.hamid@ppukm.ukm.edu.my.
LA  - eng
PT  - Journal Article
PL  - Malaysia
TA  - Med J Malaysia
JT  - The Medical journal of Malaysia
JID - 0361547
RN  - 0 (Bronchodilator Agents)
RN  - Pulmonary Disease, Chronic Obstructive, Severe Early-Onset
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Bronchodilator Agents/therapeutic use
MH  - Oscillometry
MH  - Tertiary Care Centers
MH  - Cross-Sectional Studies
MH  - Forced Expiratory Volume
MH  - *Asthma/diagnosis/drug therapy
MH  - *Pulmonary Disease, Chronic Obstructive
EDAT- 2024/01/30 06:42
MHDA- 2024/01/31 06:42
CRDT- 2024/01/30 02:33
PHST- 2024/01/31 06:42 [medline]
PHST- 2024/01/30 06:42 [pubmed]
PHST- 2024/01/30 02:33 [entrez]
PST - ppublish
SO  - Med J Malaysia. 2024 Jan;79(1):21-27.