PMID- 38288723
OWN - NLM
STAT- MEDLINE
DCOM- 20240305
LR  - 20240305
IS  - 1543-8392 (Electronic)
IS  - 1543-8384 (Linking)
VI  - 21
IP  - 3
DP  - 2024 Mar 4
TI  - Revolutionizing Wound Healing: Exploring Scarless Solutions through Drug Delivery 
      Innovations.
PG  - 1056-1076
LID - 10.1021/acs.molpharmaceut.3c01072 [doi]
AB  - Human skin is the largest organ and outermost surface of the human body, and due 
      to the continuous exposure to various challenges, it is prone to develop 
      injuries, customarily known as wounds. Although various tissue engineering 
      strategies and bioactive wound matrices have been employed to speed up wound 
      healing, scarring remains a significant challenge. The wound environment is harsh 
      due to the presence of degradative enzymes and elevated pH levels, and the 
      physiological processes involved in tissue regeneration operate on distinct time 
      scales. Therefore, there is a need for effective drug delivery systems (DDSs) to 
      address these issues. The objective of this review is to provide a comprehensive 
      exposition of the mechanisms underlying the skin healing process, the factors and 
      materials used in engineering DDSs, and the different DDSs used in wound care. 
      Furthermore, this investigation will delve into the examination of emergent 
      technologies and potential avenues for enhancing the efficacy of wound care 
      devices.
FAU - Alavi, Seyed Ebrahim
AU  - Alavi SE
AUID- ORCID: 0000-0003-4009-4921
AD  - Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, 
      Queensland 4102, Australia.
FAU - Alavi, Seyed Zeinab
AU  - Alavi SZ
AD  - Immunology of Infectious Diseases Research Center, Research Institute of Basic 
      Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan 7718175911, 
      Iran.
FAU - Nisa, Mehr Un
AU  - Nisa MU
AD  - Nishtar Medical University and Hospital, Multan 60000, Pakistan.
FAU - Koohi, Maedeh
AU  - Koohi M
AD  - Immunology of Infectious Diseases Research Center, Research Institute of Basic 
      Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan 7718175911, 
      Iran.
FAU - Raza, Aun
AU  - Raza A
AD  - School of Pharmacy, Jiangsu University, Zhenjiang 202013, PR China.
FAU - Ebrahimi Shahmabadi, Hasan
AU  - Ebrahimi Shahmabadi H
AD  - Immunology of Infectious Diseases Research Center, Research Institute of Basic 
      Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan 7718175911, 
      Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240130
PL  - United States
TA  - Mol Pharm
JT  - Molecular pharmaceutics
JID - 101197791
SB  - IM
MH  - Humans
MH  - *Wound Healing
MH  - *Skin/pathology
MH  - Cicatrix/pathology
MH  - Tissue Engineering
MH  - Drug Delivery Systems
OTO - NOTNLM
OT  - Cytokines
OT  - infection
OT  - keratinocytes
OT  - pharmacology
OT  - scar
OT  - wound healing
EDAT- 2024/01/30 12:44
MHDA- 2024/03/05 06:43
CRDT- 2024/01/30 07:54
PHST- 2024/03/05 06:43 [medline]
PHST- 2024/01/30 12:44 [pubmed]
PHST- 2024/01/30 07:54 [entrez]
AID - 10.1021/acs.molpharmaceut.3c01072 [doi]
PST - ppublish
SO  - Mol Pharm. 2024 Mar 4;21(3):1056-1076. doi: 10.1021/acs.molpharmaceut.3c01072. 
      Epub 2024 Jan 30.