PMID- 38289884
OWN - NLM
STAT- MEDLINE
DCOM- 20240201
LR  - 20240418
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 38
IP  - 1
DP  - 2024 Jan
TI  - The influence of socioeconomic deprivation on outcomes in transplant patients 
      infected with SARS-CoV-2 in Wales.
PG  - e15245
LID - 10.1111/ctr.15245 [doi]
AB  - INTRODUCTION: SARS-CoV-2 infection has had a significant impact on vulnerable 
      individuals including transplant patients. Socioeconomic deprivation negatively 
      affects outcomes of many health conditions. The aim of this study was to evaluate 
      the effect of socioeconomic deprivation on the incidence and severity of 
      SARS-CoV-2 infection among Welsh transplant patients. METHODS: This study is a 
      retrospective, cross-sectional study on the transplant population of Wales. The 
      Welsh Index of Multiple Deprivation (WIMD) was used to assess the influence of 
      socioeconomic deprivation on outcomes of Welsh transplant patients who developed 
      SARS-CoV-2 infection. Outcome measures were the incidence of SARS-CoV-2 
      infection, rates of hospital and ICU admission, development of acute kidney 
      injury (AKI) and mortality. A logistic binomial regression analysis was used to 
      correlate the various risk factors with the incidence of SARS-CoV-2 infection. 
      RESULTS: Two hundred and sixty-six (25%) of regular follow up patients had 
      SARS-CoV-2 infection; of these 55 (20.7%) were admitted, 15 (5.6%) to ICU, 37 
      (13.9%) developed AKI, and 23 (8.6%) died. In a regression analysis, patients of 
      younger age were associated with more (p = .001) and those with SPK (simultaneous 
      pancreas kidney) transplant less chance of infection (p = .038), whereas social 
      deprivation was not associated with the chance of infection (p = .14). In 
      regression analysis increased social deprivation was associated with higher 
      chance of AKI post SARS-CoV-2 (p = .049). CONCLUSIONS: Socioeconomic deprivation 
      did not affect the rates or severity of SARS-CoV-2 infection apart from the 
      degree of AKI in Welsh Transplant patients. Adherence to the preventive measures 
      for this high-risk population must continue to remain a priority.
CI  - (c) 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Koimtzis, Georgios
AU  - Koimtzis G
AUID- ORCID: 0000-0002-0669-6980
AD  - Cardiff Transplant Unit, Cardiff & Vale University Health Board, University 
      Hospital of Wales, Cardiff, UK.
FAU - Geropoulos, Georgios
AU  - Geropoulos G
AUID- ORCID: 0000-0002-2066-7975
AD  - Cardiff Transplant Unit, Cardiff & Vale University Health Board, University 
      Hospital of Wales, Cardiff, UK.
FAU - Chalklin, Christopher
AU  - Chalklin C
AUID- ORCID: 0000-0001-6206-8420
AD  - Cardiff Transplant Unit, Cardiff & Vale University Health Board, University 
      Hospital of Wales, Cardiff, UK.
FAU - Karniadakis, Ioannis
AU  - Karniadakis I
AUID- ORCID: 0000-0001-9924-0044
AD  - Cardiff Transplant Unit, Cardiff & Vale University Health Board, University 
      Hospital of Wales, Cardiff, UK.
FAU - Szabo, Laszlo
AU  - Szabo L
AUID- ORCID: 0000-0002-6881-1542
AD  - Cardiff Transplant Unit, Cardiff & Vale University Health Board, University 
      Hospital of Wales, Cardiff, UK.
FAU - Ilham, Mohammed Adel
AU  - Ilham MA
AD  - Cardiff Transplant Unit, Cardiff & Vale University Health Board, University 
      Hospital of Wales, Cardiff, UK.
FAU - Stephens, Michael
AU  - Stephens M
AD  - Cardiff Transplant Unit, Cardiff & Vale University Health Board, University 
      Hospital of Wales, Cardiff, UK.
FAU - Asderakis, Argiris
AU  - Asderakis A
AUID- ORCID: 0000-0001-6859-2020
AD  - Cardiff Transplant Unit, Cardiff & Vale University Health Board, University 
      Hospital of Wales, Cardiff, UK.
AD  - Wales Kidney Research Unit, Division of Infection and Immunity, Cardiff 
      University, Cardiff, UK.
FAU - Khalid, Usman
AU  - Khalid U
AUID- ORCID: 0000-0002-6710-4686
AD  - Cardiff Transplant Unit, Cardiff & Vale University Health Board, University 
      Hospital of Wales, Cardiff, UK.
AD  - Wales Kidney Research Unit, Division of Infection and Immunity, Cardiff 
      University, Cardiff, UK.
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
SB  - IM
MH  - Humans
MH  - SARS-CoV-2
MH  - *COVID-19/epidemiology
MH  - Wales/epidemiology
MH  - Retrospective Studies
MH  - Cross-Sectional Studies
MH  - Socioeconomic Factors
MH  - *Acute Kidney Injury/epidemiology/etiology
OTO - NOTNLM
OT  - SARS-CoV-2
OT  - kidney transplant
OT  - pancreas transplant
OT  - social deprivation
OT  - socioeconomic deprivation
EDAT- 2024/01/30 18:42
MHDA- 2024/02/01 06:42
CRDT- 2024/01/30 13:13
PHST- 2024/01/03 00:00 [revised]
PHST- 2023/09/12 00:00 [received]
PHST- 2024/01/08 00:00 [accepted]
PHST- 2024/02/01 06:42 [medline]
PHST- 2024/01/30 18:42 [pubmed]
PHST- 2024/01/30 13:13 [entrez]
AID - 10.1111/ctr.15245 [doi]
PST - ppublish
SO  - Clin Transplant. 2024 Jan;38(1):e15245. doi: 10.1111/ctr.15245.