PMID- 38291206
OWN - NLM
STAT- MEDLINE
DCOM- 20240226
LR  - 20240308
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 31
IP  - 10
DP  - 2024 Feb
TI  - Analysis, residue behaviour and risk assessment of combination product of 
      iprovalicarb + copper oxychloride in representative fruiting vegetables, cucurbit 
      and in soil using LC-MS/MS and ICP-MS.
PG  - 15186-15198
LID - 10.1007/s11356-024-32135-1 [doi]
AB  - Combination product of two herbicides, i.e. iprovalicarb and copper oxychloride, 
      is a new formulation. There is paucity of data on the dissipation pattern and 
      risk assessment of this combination product in crops. To understand the 
      dissipation behaviour/kinetics of this product, a supervised field trial was 
      undertaken on cucumber and tomato. Method validation for a QuEChERS-based method 
      for analysis of these pesticides from cucumber and tomato matrices reveals that 
      all the parameters were within the acceptance range in accordance with SANTE. The 
      limit of quantitation (LOQ) for iprovalicarb in cucumber and tomato fruits, and 
      in soil matrices when analysed on LC-MS/MS was established at 0.01 mg kg(-1). 
      Similarly, the LOQ for copper oxychloride (as copper) on ICP-MS was established 
      at 0.5 mg kg(-1) in cucumber and tomato fruits and 5.0 mg kg(-1) in soil. 
      Dissipation of iprovalicarb was slower in tomato fruits as compared to cucumber 
      fruits. The initial accumulation of the residues of iprovalicarb was 0.073 and 
      0.243 mg kg(-1) in cucumber and 0.214 and 0.432 mg kg(-1) in tomato fruits at 
      standard and double dose, respectively. Similarly, copper oxychloride residues 
      were 3.51 and 6.45 mg kg(-1) in cucumber and 1.26 and 2.56 mg kg(-1) in tomato 
      fruits at standard and double dose, respectively. The residues were below LOQ in 
      cucumber fruits, tomato fruits and soil at the time of harvest. The residues of 
      copper oxychloride persisted till harvest time in cucumber fruits and in soil. A 
      preharvest interval (PHI) of 3 day is recommended on safer side for the 
      combination product of iprovalicarb + copper oxychloride. Theoretical maximum 
      daily intake (TMDI) is less than maximum permissible intake (MPI) for 
      iprovalicarb and copper oxychloride at both the doses from 0 day and onward. The 
      results from the present study can be of immense importance for establishing 
      label claims, maximum residue limits (MRLs) and risk assessment by national and 
      international regulatory agencies.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Kalasariya, Ravi L
AU  - Kalasariya RL
AD  - Pesticide Residue Laboratory, AINP on Pesticide Residues, Anand Agricultural 
      University, Anand, 388110, Gujarat, India.
FAU - Chaudhary, Nidhi N
AU  - Chaudhary NN
AD  - Pesticide Residue Laboratory, AINP on Pesticide Residues, Anand Agricultural 
      University, Anand, 388110, Gujarat, India.
FAU - Patel, Mitesh R
AU  - Patel MR
AD  - Pesticide Residue Laboratory, AINP on Pesticide Residues, Anand Agricultural 
      University, Anand, 388110, Gujarat, India.
FAU - Chawla, Suchi
AU  - Chawla S
AUID- ORCID: 0000-0003-2031-3998
AD  - Pesticide Residue Laboratory, AINP on Pesticide Residues, Anand Agricultural 
      University, Anand, 388110, Gujarat, India. suchisood10@yahoo.co.uk.
FAU - Parmar, Kaushikkumar D
AU  - Parmar KD
AD  - Pesticide Residue Laboratory, AINP on Pesticide Residues, Anand Agricultural 
      University, Anand, 388110, Gujarat, India.
FAU - Rathod, Pareshkumar H
AU  - Rathod PH
AD  - Pesticide Residue Laboratory, AINP on Pesticide Residues, Anand Agricultural 
      University, Anand, 388110, Gujarat, India.
LA  - eng
PT  - Journal Article
DEP - 20240130
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 94Q9V45M9B (iprovalicarb)
RN  - 76712031PG (copper oxychloride)
RN  - 789U1901C5 (Copper)
RN  - 0 (Soil)
RN  - 0 (Pesticide Residues)
RN  - 0 (Carbamates)
RN  - HG18B9YRS7 (Valine)
SB  - IM
EIN - Environ Sci Pollut Res Int. 2024 Feb 16;:. PMID: 38363511
MH  - Vegetables/chemistry
MH  - Copper/analysis
MH  - Liquid Chromatography-Mass Spectrometry
MH  - Chromatography, Liquid
MH  - Soil/chemistry
MH  - Fruit/chemistry
MH  - Tandem Mass Spectrometry
MH  - *Cucumis sativus/chemistry
MH  - Risk Assessment
MH  - *Pesticide Residues/analysis
MH  - *Carbamates
MH  - Valine/*analogs & derivatives
OTO - NOTNLM
OT  - Copper oxychloride
OT  - Cucurbits
OT  - Dissipation
OT  - Fruiting vegetables
OT  - Iprovalicarb
OT  - Risk assessment
OT  - Soil
EDAT- 2024/01/31 00:42
MHDA- 2024/02/26 06:44
CRDT- 2024/01/30 23:29
PHST- 2023/10/25 00:00 [received]
PHST- 2024/01/18 00:00 [accepted]
PHST- 2024/02/26 06:44 [medline]
PHST- 2024/01/31 00:42 [pubmed]
PHST- 2024/01/30 23:29 [entrez]
AID - 10.1007/s11356-024-32135-1 [pii]
AID - 10.1007/s11356-024-32135-1 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2024 Feb;31(10):15186-15198. doi: 
      10.1007/s11356-024-32135-1. Epub 2024 Jan 30.