PMID- 38291968
OWN - NLM
STAT- MEDLINE
DCOM- 20240215
LR  - 20240215
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 12
IP  - 7
DP  - 2024 Feb 14
TI  - Schottky heterojunction CeO(2)@MXene nanosheets with synergistic type I and type 
      II PDT for anti-osteosarcoma.
PG  - 1816-1825
LID - 10.1039/d3tb02835f [doi]
AB  - Photodynamic therapy (PDT) has shown great potential for tumor treatment as the 
      method is noninvasive, highly selective, and causes minimal side effects. 
      However, conventional type II PDT, which relies on (1)O(2), presents poor 
      therapeutic efficacy for hypoxic tumors due to its reliance on oxygen. Here, 
      CeO(2)/Ti(3)C(2)-MXene (CeO(2)@MXene) hybrids were successfully designed by 
      growing CeO(2)in situ using Ti(3)C(2)-MXene (MXene) nanosheets. CeO(2)@MXene 
      serves as a reduction-oxidation (REDOX) center due to the presence of Ce in the 
      lattice of CeO(2) nanoparticles. This REDOX center reacts with H(2)O(2) to 
      generate oxygen and weakens the hypoxic tumor cell environment, achieving type II 
      PDT. At the same time, many other ROS (such as ⋅O(2)(-) and ⋅OH) can be produced 
      via a type I photodynamic mechanism (electron transfer process). The CeO(2)@MXene 
      heterojunction performs nanoenzymatic functions for synergistic type I and type 
      II PDT, which improves cancer treatment.
FAU - Zheng, Bingxin
AU  - Zheng B
AD  - Department of Orthopedic Oncology, The Affiliated Hospital of Qingdao University, 
      Qingdao, Peoples Republic of China. bonetumoryb@qdu.edu.cn.
FAU - Zhang, Ranran
AU  - Zhang R
AD  - Key Laboratory of Marine Chemistry Theory and Technology (Ocean University of 
      China), Ministry of Education, Qingdao 266100, China. mengqiu@ouc.edu.cn.
FAU - Kuang, Fei
AU  - Kuang F
AD  - Qingdao University, College of Life Sciences, 308 Ningxia Road, Qingdao, Shandong 
      Province, China.
FAU - Hui, Tiankun
AU  - Hui T
AD  - Key Laboratory of Marine Chemistry Theory and Technology (Ocean University of 
      China), Ministry of Education, Qingdao 266100, China. mengqiu@ouc.edu.cn.
FAU - Fu, Chenchen
AU  - Fu C
AD  - Key Laboratory of Marine Chemistry Theory and Technology (Ocean University of 
      China), Ministry of Education, Qingdao 266100, China. mengqiu@ouc.edu.cn.
FAU - Zhang, Li
AU  - Zhang L
AD  - Department of Operating Room, The Affiliated Hospital of Qingdao University, 
      Qingdao, People's Republic of China.
FAU - Zhou, Chuanli
AU  - Zhou C
AD  - Department of Spinal Surgery, The Affiliated Hospital of Qingdao University, 
      Qingdao, People's Republic of China.
FAU - Qiu, Meng
AU  - Qiu M
AUID- ORCID: 0000-0002-0178-3479
AD  - Key Laboratory of Marine Chemistry Theory and Technology (Ocean University of 
      China), Ministry of Education, Qingdao 266100, China. mengqiu@ouc.edu.cn.
FAU - Yue, Bin
AU  - Yue B
AD  - Department of Orthopedic Oncology, The Affiliated Hospital of Qingdao University, 
      Qingdao, Peoples Republic of China. bonetumoryb@qdu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20240214
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
RN  - 0 (MXene)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - S88TT14065 (Oxygen)
RN  - 0 (Nitrites)
RN  - 0 (Transition Elements)
SB  - IM
MH  - Humans
MH  - Hydrogen Peroxide
MH  - *Osteosarcoma
MH  - Hypoxia
MH  - Oxygen
MH  - *Bone Neoplasms
MH  - *Nitrites
MH  - *Transition Elements
EDAT- 2024/01/31 06:42
MHDA- 2024/02/15 06:43
CRDT- 2024/01/31 03:43
PHST- 2024/02/15 06:43 [medline]
PHST- 2024/01/31 06:42 [pubmed]
PHST- 2024/01/31 03:43 [entrez]
AID - 10.1039/d3tb02835f [doi]
PST - epublish
SO  - J Mater Chem B. 2024 Feb 14;12(7):1816-1825. doi: 10.1039/d3tb02835f.