PMID- 38292586
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240201
IS  - 2364-3722 (Print)
IS  - 2196-9736 (Electronic)
IS  - 2196-9736 (Linking)
VI  - 12
IP  - 1
DP  - 2024 Jan
TI  - Device-assisted enteroscopy in the surveillance of intestinal hamartomas in 
      Peutz-Jeghers syndrome.
PG  - E128-E134
LID - 10.1055/a-2197-8554 [doi]
AB  - Background and study aims Peutz-Jeghers syndrome (PJS) is an autosomal-dominant 
      genetic disorder characterized by the formation of hamartomatous polyps in the 
      gastrointestinal tract. These polyps result in significant morbidity due to 
      adverse events (AEs) including intestinal obstruction, bleeding, and malignancy. 
      The aim of this study was to describe the role of device-assisted enteroscopy 
      (DAE) in monitoring and prophylactic polypectomy within the small bowel. Patients 
      and methods Electronic medical records were surveyed to identify all DAE 
      procedures performed in patients with PJS at three US referral centers between 
      January 1, 2007 and January 1, 2020. Individual charts were reviewed to collect 
      and analyze specific data points. Primary end points included AEs associated with 
      DAE-related polypectomy and the rate of laparotomy in PJS patients prior to, and 
      following, index DAE. Secondary data points included patient characteristics, 
      procedural details, and size/location/distribution of small bowel hamartomas. 
      Results Twenty-three patients met our inclusion criteria. Of these, 18 (75%) had 
      previously undergone small bowel surgery prior to index DAE. Between 2007 and 
      2020, 46 DAEs were performed in these patients with an average of one exam every 
      2.5 years. A total of 131 polypectomies were performed with an AE rate of 1.5%. 
      None of our cohort required emergent surgery related to AEs of small bowel 
      hamartomas over 336 years of aggregated follow-up. Conclusions Endoscopic 
      management of small bowel polyps in patients with PJS using DAE is an effective 
      strategy for prophylactic removal of hamartomas. DAE surveillance and endoscopic 
      polypectomy is safe and may decrease the need for repeated laparotomy in patients 
      with PJS.
CI  - The Author(s). This is an open access article published by Thieme under the terms 
      of the Creative Commons Attribution-NonDerivative-NonCommercial-License, 
      permitting copying and reproduction so long as the original work is given 
      appropriate credit. Contents may not be used for commercial purposes, or adapted, 
      remixed, transformed or built upon. 
      (https://creativecommons.org/licenses/by-nc-nd/4.0/).
FAU - Mohamed Elfeky, Omar Wahid
AU  - Mohamed Elfeky OW
AD  - Internal Medicine, LSU Health New Orleans, New Orleans, United States. RINGGOLD: 
      12258
FAU - Panjwani, Suraj
AU  - Panjwani S
AD  - Gastroenterology, University of Massachusetts Chan Medical School Department of 
      Medicine, Worcester, United States. RINGGOLD: 164186
FAU - Cave, David
AU  - Cave D
AD  - Gastroenterology, University of Massachusetts Chan Medical School Department of 
      Medicine, Worcester, United States. RINGGOLD: 164186
FAU - Wild, Daniel
AU  - Wild D
AD  - Gastroenterology, Duke University Medical Center, Durham, United States.
FAU - Raines, Daniel
AU  - Raines D
AD  - Gastroenterology, LSU Health New Orleans, New Orleans, United States. RINGGOLD: 
      12258
LA  - eng
PT  - Journal Article
DEP - 20240130
PL  - Germany
TA  - Endosc Int Open
JT  - Endoscopy international open
JID - 101639919
PMC - PMC10827474
OTO - NOTNLM
OT  - Laparoscopy
OT  - Small bowel endoscopy
COIS- Conflict of Interest Daniel Raines, MD Consultant: Fujifilm Speaker: Medtronic. 
      All other authors declare that they have no conflicts of interest.
EDAT- 2024/01/31 06:43
MHDA- 2024/01/31 06:44
PMCR- 2024/01/01
CRDT- 2024/01/31 04:13
PHST- 2023/04/06 00:00 [received]
PHST- 2023/10/24 00:00 [accepted]
PHST- 2024/01/31 06:44 [medline]
PHST- 2024/01/31 06:43 [pubmed]
PHST- 2024/01/31 04:13 [entrez]
PHST- 2024/01/01 00:00 [pmc-release]
AID - EIO-2023-04-2982-OA [pii]
AID - 10.1055/a-2197-8554 [doi]
PST - epublish
SO  - Endosc Int Open. 2024 Jan 30;12(1):E128-E134. doi: 10.1055/a-2197-8554. 
      eCollection 2024 Jan.