PMID- 38292591 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240311 IS - 2364-3722 (Print) IS - 2196-9736 (Electronic) IS - 2196-9736 (Linking) VI - 12 IP - 1 DP - 2024 Jan TI - Clinical usefulness of tissue acquisition of pancreatic cystic lesions using an endoscopic ultrasound-guided needle for histological analysis. PG - E155-E163 LID - 10.1055/a-2240-0678 [doi] AB - Background and study aims There are rare data on the usefulness of endosonography-guided tissue acquisition (EUS-TA) in patients with pancreatic cystic lesions (PCLs). This study aimed to determine the accuracy of EUS-TA with ProCore 20G (PC20) for differentiating between mucinous neoplasia (MN) and non-MNs (n-MN) and identifying malignant PCLs, as well as its adverse events (AEs) in patients with PCLs without a classificatory diagnosis by imaging exams. Patients and methods In this observational, retrospective, single-center study, all patients with PCL who underwent EUS-TA due to diagnostic doubts in imaging studies were consecutively recruited from June 2017 to December 2021. The outcomes were to determine the diagnostic accuracy of EUS-TA with PC20 for differentiating between MN and n-MN, identifying malignant PCLs, and the AEs. Results Herein, 145 patients underwent EUS-TA, with 83 women (57.2%) and a mean age of 62.2 years. The mean size was 2.3 cm, with 81 patients (77.9%) having a PCL < 3.0 cm. The final diagnosis was made by EUS-TA (n = 81), surgery (n = 58), and follow-up (n = 6). The sensitivity, specificity, positive and negative predictive values, and accuracy for differentiating between MNs and n-MNs and identifying malignant PCLs were 92.6%, 98.4%, 98.7%, 91.3%, and 95.2% (kappa=0.9), and 92%, 99.2%, 95.8%, 98.3%, and 97.9% (kappa = 0.93), respectively. The AE rate was 2.7%, with no deaths in this cohort. Conclusions EUS-TA with PC20 has high accuracy and technical success with a low AE rate for PCL diagnosis. CI - The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/). FAU - Castro, Juliana Silveira Lima de AU - Castro JSL AUID- ORCID: 0000-0003-0280-8356 AD - Diagnostic Imaging, Universidade Federal de Sao Paulo Departamento de Diagnostico por Imagem, Sao Paulo, Brazil. RINGGOLD: 368471 AD - Endoscopy, ACCamargo Cancer Center, Sao Paulo, Brazil. RINGGOLD: 139300 FAU - Taglieri, Eloy AU - Taglieri E AD - Endoscopy, ACCamargo Cancer Center, Sao Paulo, Brazil. RINGGOLD: 139300 AD - Endoscopy, Hospital Moriah, Sao Paulo, Brazil. RINGGOLD: 476599 AD - Endoscopy, Hospital 9 de Julho, Sao Paulo, Brazil. RINGGOLD: 245166 FAU - Neto, Otavio Micelli AU - Neto OM AD - Endoscopy, ACCamargo Cancer Center, Sao Paulo, Brazil. RINGGOLD: 139300 AD - Endoscopy, Hospital Moriah, Sao Paulo, Brazil. RINGGOLD: 476599 AD - Endoscopy, Hospital 9 de Julho, Sao Paulo, Brazil. RINGGOLD: 245166 FAU - Guerra, Joao Guilherme AU - Guerra JG AD - Endoscopy, ACCamargo Cancer Center, Sao Paulo, Brazil. RINGGOLD: 139300 AD - Endoscopy, Hospital Moriah, Sao Paulo, Brazil. RINGGOLD: 476599 FAU - Venco, Filadelfio Euclides AU - Venco FE AD - Pathology, Hospital Moriah, Sao Paulo, Brazil. RINGGOLD: 476599 FAU - Andrade, Eliza AU - Andrade E AD - Endoscopy, ACCamargo Cancer Center, Sao Paulo, Brazil. RINGGOLD: 139300 FAU - Seraphim, Alvaro Moura AU - Seraphim AM AD - Endoscopy, ACCamargo Cancer Center, Sao Paulo, Brazil. RINGGOLD: 139300 FAU - Romanini, Samuel Galante AU - Romanini SG AD - Endoscopy, Hospital 9 de Julho, Sao Paulo, Brazil. RINGGOLD: 245166 FAU - Torres, Isabela Trindade AU - Torres IT AD - Endoscopy, Hospital 9 de Julho, Sao Paulo, Brazil. RINGGOLD: 245166 FAU - Serrano, Juan Pablo Roman AU - Serrano JPR AUID- ORCID: 0000-0002-0453-5323 AD - Endoscopy, Hospital General Luis Vernaza, Guayaquil, Ecuador. RINGGOLD: 92938 FAU - Goldman, Suzan Menasce AU - Goldman SM AD - Diagnostic Imaging, Universidade Federal de Sao Paulo Departamento de Diagnostico por Imagem, Sao Paulo, Brazil. RINGGOLD: 368471 FAU - Kemp, Rafael AU - Kemp R AD - Surgery and Anatomy, Universidade de Sao Paulo Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto, Ribeirao Preto, Brazil. RINGGOLD: 67796 FAU - Dos Santos, Jose Sebastiao AU - Dos Santos JS AD - Surgery and Anatomy, Universidade de Sao Paulo Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto, Ribeirao Preto, Brazil. RINGGOLD: 67796 FAU - Ardengh, Jose Celso AU - Ardengh JC AUID- ORCID: 0000-0002-5932-2499 AD - Diagnostic Imaging, Universidade Federal de Sao Paulo Departamento de Diagnostico por Imagem, Sao Paulo, Brazil. RINGGOLD: 368471 AD - Endoscopy, Hospital Moriah, Sao Paulo, Brazil. RINGGOLD: 476599 AD - Surgery and Anatomy, Universidade de Sao Paulo Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto, Ribeirao Preto, Brazil. RINGGOLD: 67796 LA - eng PT - Journal Article DEP - 20240130 PL - Germany TA - Endosc Int Open JT - Endoscopy international open JID - 101639919 CIN - Endosc Int Open. 2024 Mar 07;12(3):E341-E343. PMID: 38464980 PMC - PMC10827479 OTO - NOTNLM OT - Endoscopic ultrasonography OT - Fine-needle aspiration/biopsy OT - Intervention EUS OT - Pancreas OT - Tissue diagnosis COIS- Conflict of Interest The authors declare that they have no conflict of interest. EDAT- 2024/01/31 06:42 MHDA- 2024/01/31 06:43 PMCR- 2024/01/01 CRDT- 2024/01/31 04:13 PHST- 2023/08/01 00:00 [received] PHST- 2024/01/04 00:00 [accepted] PHST- 2024/01/31 06:43 [medline] PHST- 2024/01/31 06:42 [pubmed] PHST- 2024/01/31 04:13 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - EIO-2023-08-3084-OA [pii] AID - 10.1055/a-2240-0678 [doi] PST - epublish SO - Endosc Int Open. 2024 Jan 30;12(1):E155-E163. doi: 10.1055/a-2240-0678. eCollection 2024 Jan.