PMID- 38294518
OWN - NLM
STAT- MEDLINE
DCOM- 20240221
LR  - 20240223
IS  - 1435-1544 (Electronic)
IS  - 0938-7412 (Print)
IS  - 0938-7412 (Linking)
VI  - 35
IP  - 1
DP  - 2024 Mar
TI  - Prognosis of pacing-dependent patients with cardiovascular implantable electronic 
      devices.
PG  - 39-45
LID - 10.1007/s00399-024-00996-1 [doi]
AB  - BACKGROUND: Data on the prognostic significance of pacing dependency in patients 
      with cardiovascular implantable electronic devices (CIEDs) are sparse. METHODS: 
      The prognostic significance of pacing dependency defined as absence of an 
      intrinsic rhythm >/= 30 bpm was determined in 786 patients with CIEDs at the 
      authors' institution using univariate and multivariate regression analysis to 
      identify predictors of all-cause mortality. RESULTS: During 49 months median 
      follow-up, death occurred in 63 of 130 patients with pacing dependency compared 
      to 241 of 656 patients without pacing dependency (48% versus 37%, hazard ratio 
      [HR] 1.34; 95% confidence interval [CI]: 1.02-1.78, P = 0.04). Using multivariate 
      regression analysis, predictors of all-cause mortality included age (HR 1.07; 95% 
      CI: 1.05-1.08, P < 0.01), history of atrial fibrillation (HR 1.32, 95% CI: 
      1.03-1.69, P < 0.01), chronic kidney disease (HR 1.28; 95% CI: 1.00-1.63, 
      P = 0.048) and New York Heart Association (NYHA) class >/= III (HR 2.00; 95% CI: 
      1.52-2.62, P < 0.01), but not pacing dependency (HR 1.15; 95% CI: 0.86-1.54, 
      P = 0.35). CONCLUSIONS: In contrast to age, atrial fibrillation, chronic kidney 
      disease and heart failure severity as indexed by NYHA functional class III or IV, 
      pacing dependency does not appear to be an independent predictor of all-cause 
      mortality in patients with CIEDs.
CI  - (c) 2024. The Author(s).
FAU - Grimm, Wolfram
AU  - Grimm W
AD  - Department of Cardiology, University Hospital of Marburg and Giessen, 
      Philipps-University Marburg, Baldingerstrasse, 35033, Marburg, Germany. 
      grimmwk.rauschenberg@t-online.de.
FAU - Erdmann, Barbara
AU  - Erdmann B
AD  - Department of Cardiology, University Hospital of Marburg and Giessen, 
      Philipps-University Marburg, Baldingerstrasse, 35033, Marburg, Germany.
FAU - Grimm, Kathrin
AU  - Grimm K
AD  - Department of Neurology, University Hospital of Erlangen, Erlangen, Germany.
FAU - Kreutz, Julian
AU  - Kreutz J
AD  - Department of Cardiology, University Hospital of Marburg and Giessen, 
      Philipps-University Marburg, Baldingerstrasse, 35033, Marburg, Germany.
FAU - Parahuleva, Mariana
AU  - Parahuleva M
AD  - Department of Cardiology, University Hospital of Marburg and Giessen, 
      Philipps-University Marburg, Baldingerstrasse, 35033, Marburg, Germany.
LA  - eng
PT  - Journal Article
TT  - Prognose schrittmacherabhangiger Patienten mit implantierbaren kardiovaskularen 
      elektrischen Geraten.
DEP - 20240131
PL  - Germany
TA  - Herzschrittmacherther Elektrophysiol
JT  - Herzschrittmachertherapie & Elektrophysiologie
JID - 9425873
SB  - IM
MH  - Humans
MH  - *Atrial Fibrillation/diagnosis/therapy
MH  - *Defibrillators, Implantable/adverse effects
MH  - Cardiac Pacing, Artificial
MH  - *Heart Failure/diagnosis/therapy/etiology
MH  - Prognosis
MH  - *Renal Insufficiency, Chronic/etiology
PMC - PMC10879369
OTO - NOTNLM
OT  - Chronic kidney disease
OT  - Heart failure
OT  - Implantable cardioverter-defibrillator
OT  - Pacing dependency
OT  - Permanent pacemaker
COIS- W. Grimm, B. Erdmann, K. Grimm, J. Kreutz and M. Parahuleva declare that they 
      have no competing interests.
EDAT- 2024/01/31 12:44
MHDA- 2024/02/21 11:16
PMCR- 2024/01/31
CRDT- 2024/01/31 11:04
PHST- 2023/10/30 00:00 [received]
PHST- 2024/01/18 00:00 [accepted]
PHST- 2024/02/21 11:16 [medline]
PHST- 2024/01/31 12:44 [pubmed]
PHST- 2024/01/31 11:04 [entrez]
PHST- 2024/01/31 00:00 [pmc-release]
AID - 10.1007/s00399-024-00996-1 [pii]
AID - 996 [pii]
AID - 10.1007/s00399-024-00996-1 [doi]
PST - ppublish
SO  - Herzschrittmacherther Elektrophysiol. 2024 Mar;35(1):39-45. doi: 
      10.1007/s00399-024-00996-1. Epub 2024 Jan 31.