PMID- 38295914
OWN - NLM
STAT- MEDLINE
DCOM- 20240304
LR  - 20240304
IS  - 1096-1186 (Electronic)
IS  - 1043-6618 (Linking)
VI  - 201
DP  - 2024 Mar
TI  - Interleukin-18 in chronic pain: Focus on pathogenic mechanisms and potential 
      therapeutic targets.
PG  - 107089
LID - S1043-6618(24)00033-1 [pii]
LID - 10.1016/j.phrs.2024.107089 [doi]
AB  - Chronic pain has been proven to be an independent disease, other than an 
      accompanying symptom of certain diseases. Interleukin-18 (IL-18), a 
      pro-inflammatory cytokine with pleiotropic biological effects, participates in 
      immune modulation, inflammatory response, tumor growth, as well as the process of 
      chronic pain. Compelling evidence suggests that IL-18 is upregulated in the 
      occurrence of chronic pain. Antagonism or inhibition of IL-18 expression can 
      alleviate the occurrence and development of chronic pain. And IL-18 is located in 
      microglia, while IL-18R is mostly located in astrocytes in the spinal cord. This 
      indicates that the interaction between microglia and astrocytes mediated by the 
      IL-18/IL-18R axis is involved in the occurrence of chronic pain. In this review, 
      we described the role and mechanism of IL-18 in different types of chronic pain. 
      This review provides strong evidence that IL-18 is a potential therapeutic target 
      in pain management.
CI  - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Ju, Jie
AU  - Ju J
AD  - Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric 
      Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for 
      Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Li, Zheng
AU  - Li Z
AD  - Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric 
      Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for 
      Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Jia, Xiaoqian
AU  - Jia X
AD  - Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric 
      Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for 
      Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Peng, Xiaoling
AU  - Peng X
AD  - Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric 
      Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for 
      Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Wang, Jihong
AU  - Wang J
AD  - Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric 
      Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for 
      Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Gao, Feng
AU  - Gao F
AD  - Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric 
      Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for 
      Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China. Electronic address: 
      fgao@tjh.tjmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240129
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
RN  - 0 (Interleukin-18)
RN  - 0 (Cytokines)
SB  - IM
MH  - Humans
MH  - *Interleukin-18/metabolism/pharmacology
MH  - *Chronic Pain/metabolism
MH  - Cytokines/metabolism
MH  - Microglia
MH  - Astrocytes
OTO - NOTNLM
OT  - Cancer pain
OT  - Central poststroke pain
OT  - Chronic pain
OT  - Interleukin-18
OT  - Neuropathic pain
OT  - Polyneuropathy
COIS- Declaration of Competing Interest The authors declare that we have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/02/01 00:42
MHDA- 2024/03/04 06:48
CRDT- 2024/01/31 19:25
PHST- 2023/10/18 00:00 [received]
PHST- 2024/01/22 00:00 [revised]
PHST- 2024/01/26 00:00 [accepted]
PHST- 2024/03/04 06:48 [medline]
PHST- 2024/02/01 00:42 [pubmed]
PHST- 2024/01/31 19:25 [entrez]
AID - S1043-6618(24)00033-1 [pii]
AID - 10.1016/j.phrs.2024.107089 [doi]
PST - ppublish
SO  - Pharmacol Res. 2024 Mar;201:107089. doi: 10.1016/j.phrs.2024.107089. Epub 2024 
      Jan 29.