PMID- 38295973
OWN - NLM
STAT- MEDLINE
DCOM- 20240419
LR  - 20240419
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 248
DP  - 2024 May 1
TI  - Toxic metals and essential trace elements in placenta and their relation to 
      placental function.
PG  - 118355
LID - S0013-9351(24)00259-7 [pii]
LID - 10.1016/j.envres.2024.118355 [doi]
AB  - INTRODUCTION: Placental function is essential for fetal development, but it may 
      be susceptible to malnutrition and environmental stressors. OBJECTIVE: To assess 
      the impact of toxic and essential trace elements in placenta on placental 
      function. METHODS: Toxic metals (cadmium, lead, mercury, cobalt) and essential 
      elements (copper, manganese, zinc, selenium) were measured in placenta of 406 
      pregnant women in northern Sweden using ICP-MS. Placental weight and birth weight 
      were obtained from hospital records and fetoplacental weight ratio was used to 
      estimate placental efficiency. Placental relative telomere length (TL) and 
      mitochondrial DNA copy number (mtDNAcn) were determined by quantitative PCR 
      (n = 285). Single exposure-outcome associations were evaluated using linear or 
      spline regression, and joint associations and interactions with Bayesian kernel 
      machine regression (BKMR), all adjusted for sex, maternal smoking, and age or 
      BMI. RESULTS: Median cadmium, mercury, lead, cobalt, copper, manganese, zinc, and 
      selenium concentrations in placenta were 3.2, 1.8, 4.3, 2.3, 1058, 66, 10626, and 
      166 mug/kg, respectively. In the adjusted regression, selenium (>147 mug/kg) was 
      inversely associated with placental weight (B: -158; 95 % CI: -246, -71, per 
      doubling), as was lead at low selenium (B: -23.6; 95 % CI: -43.2, -4.0, per 
      doubling). Manganese was positively associated with placental weight (B: 41; 95 % 
      CI: 5.9, 77, per doubling) and inversely associated with placental efficiency (B: 
      -0.01; 95 % CI: -0.019, -0.004, per doubling). Cobalt was inversely associated 
      with mtDNAcn (B: -11; 95 % CI: -20, -0.018, per doubling), whereas all essential 
      elements were positively associated with mtDNAcn, individually and joint. 
      CONCLUSION: Among the toxic metals, lead appeared to negatively impact placental 
      weight and cobalt decreased placental mtDNAcn. Joint essential element 
      concentrations increased placental mtDNAcn. Manganese also appeared to increase 
      placental weight, but not birth weight. The inverse association of selenium with 
      placental weight may reflect increased transport of selenium to the fetus in late 
      gestation.
CI  - Copyright (c) 2024 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Grundeken, Marijke
AU  - Grundeken M
AD  - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
FAU - Gustin, Klara
AU  - Gustin K
AD  - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. 
      Electronic address: Klara.Gustin.Mossegard@ki.se.
FAU - Vahter, Marie
AU  - Vahter M
AD  - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
FAU - Delaval, Mathilde
AU  - Delaval M
AD  - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; 
      Joint Mass Spectrometry Centre (JMSC), Cooperation Group Comprehensive Molecular 
      Analytics, Helmholtz Zentrum Munchen, Neuherberg, Germany.
FAU - Barman, Malin
AU  - Barman M
AD  - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; 
      Food and Nutrition Science, Department of Biology and Biological Engineering, 
      Chalmers University of Technology, Gothenburg, Sweden.
FAU - Sandin, Anna
AU  - Sandin A
AD  - Department of Clinical Science, Pediatrics, Sunderby Research Unit, Umea 
      University, Sweden.
FAU - Sandberg, Ann-Sofie
AU  - Sandberg AS
AD  - Food and Nutrition Science, Department of Biology and Biological Engineering, 
      Chalmers University of Technology, Gothenburg, Sweden.
FAU - Wold, Agnes E
AU  - Wold AE
AD  - Institute of Biomedicine, Dept, Of Infectious Diseases, Sahlgrenska Academy, 
      University of Gothenburg, Gothenburg, Sweden.
FAU - Broberg, Karin
AU  - Broberg K
AD  - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
FAU - Kippler, Maria
AU  - Kippler M
AD  - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
LA  - eng
PT  - Journal Article
DEP - 20240129
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Trace Elements)
RN  - H6241UJ22B (Selenium)
RN  - 789U1901C5 (Copper)
RN  - 42Z2K6ZL8P (Manganese)
RN  - 00BH33GNGH (Cadmium)
RN  - J41CSQ7QDS (Zinc)
RN  - FXS1BY2PGL (Mercury)
RN  - 3G0H8C9362 (Cobalt)
RN  - 0 (DNA, Mitochondrial)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - Placenta
MH  - *Trace Elements
MH  - *Selenium
MH  - Copper
MH  - Manganese
MH  - Cadmium
MH  - Bayes Theorem
MH  - Zinc
MH  - Birth Weight
MH  - *Mercury
MH  - Cobalt
MH  - DNA, Mitochondrial
OTO - NOTNLM
OT  - Essential trace elements
OT  - Micronutrients
OT  - Mitochondrial DNA
OT  - Placental function
OT  - Telomere length
OT  - Toxic metals
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/02/01 00:42
MHDA- 2024/04/19 06:43
CRDT- 2024/01/31 19:27
PHST- 2023/11/10 00:00 [received]
PHST- 2024/01/26 00:00 [revised]
PHST- 2024/01/28 00:00 [accepted]
PHST- 2024/04/19 06:43 [medline]
PHST- 2024/02/01 00:42 [pubmed]
PHST- 2024/01/31 19:27 [entrez]
AID - S0013-9351(24)00259-7 [pii]
AID - 10.1016/j.envres.2024.118355 [doi]
PST - ppublish
SO  - Environ Res. 2024 May 1;248:118355. doi: 10.1016/j.envres.2024.118355. Epub 2024 
      Jan 29.