PMID- 38296493
OWN - NLM
STAT- MEDLINE
DCOM- 20240214
LR  - 20240214
IS  - 1347-5231 (Electronic)
IS  - 0031-6903 (Linking)
VI  - 144
IP  - 2
DP  - 2024
TI  - [Preparation of Nanoplastic Particles as Potential Standards for the Study of 
      Nanoplastics].
PG  - 165-170
LID - 10.1248/yakushi.23-00152-1 [doi]
AB  - Nanoplastics (NPs) are plastic fragments that are small enough to be absorbed by 
      organisms through ingestion or inhalation. Recent studies indicate that 
      nanoplastics can be ubiquitous in the environment, and there are growing concerns 
      regarding the impacts of nanoplastics on the health of humans and other 
      organisms. However, quantitative information on nanoplastics in the environment 
      is still very limited, and most previous toxicity studies have used only 
      polystyrene (PS) particles because of a lack of appropriate model particles of 
      other plastics. We developed a nanoprecipitation-based method for the preparation 
      of nanoplastic particles of five major polymers: low-density polyethylene (LDPE), 
      high-density polyethylene (HDPE), polypropylene (PP), polyvinyl chloride (PVC), 
      and polystyrene. A major advantage of our method is that the nanoplastic 
      particles are prepared without using reagents that can remain in the particles as 
      impurities. Analysis of the prepared particles' molecular weight (M(w)) 
      distributions, crystallinities, and thermal properties revealed that their 
      compositions and constitutions were within the general ranges for commercial 
      products. The mechanisms underlying the formation of low-density polyethylene 
      particles via our method were investigated by means of a simple population 
      balance model, and particle diameter was found to be linearly correlated with the 
      suspension density of the nanoplastic dispersion up to 0.4 mg.mL(-1). Future 
      studies should focus on improving our method to allow for precise, 
      scale-independent production of nanoplastic particles. Methods for the 
      preparation of labeled particles are also needed so that such particles can be 
      used in nanoplastic risk assessments.
FAU - Tanaka, Kosuke
AU  - Tanaka K
AD  - Material Cycles Division, National Institute for Environmental Studies.
FAU - Takahashi, Yusuke
AU  - Takahashi Y
AD  - Material Cycles Division, National Institute for Environmental Studies.
FAU - Kuramochi, Hidetoshi
AU  - Kuramochi H
AD  - Material Cycles Division, National Institute for Environmental Studies.
FAU - Osako, Masahiro
AU  - Osako M
AD  - Material Cycles Division, National Institute for Environmental Studies.
FAU - Suzuki, Go
AU  - Suzuki G
AD  - Material Cycles Division, National Institute for Environmental Studies.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Yakugaku Zasshi
JT  - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
JID - 0413613
RN  - 0 (Polystyrenes)
RN  - 0 (Plastics)
RN  - 0 (Microplastics)
RN  - 9002-88-4 (Polyethylene)
RN  - 0 (Polymers)
SB  - IM
MH  - Humans
MH  - *Polystyrenes
MH  - *Plastics
MH  - Microplastics/analysis
MH  - Polyethylene
MH  - Polymers
OTO - NOTNLM
OT  - model particle
OT  - nanoplastics (NPs)
OT  - nanoprecipitation
EDAT- 2024/02/01 00:42
MHDA- 2024/02/14 12:46
CRDT- 2024/01/31 21:03
PHST- 2024/02/14 12:46 [medline]
PHST- 2024/02/01 00:42 [pubmed]
PHST- 2024/01/31 21:03 [entrez]
AID - 10.1248/yakushi.23-00152-1 [doi]
PST - ppublish
SO  - Yakugaku Zasshi. 2024;144(2):165-170. doi: 10.1248/yakushi.23-00152-1.