PMID- 38297283
OWN - NLM
STAT- MEDLINE
DCOM- 20240202
LR  - 20240206
IS  - 1471-2431 (Electronic)
IS  - 1471-2431 (Linking)
VI  - 24
IP  - 1
DP  - 2024 Jan 31
TI  - Multivitamin consumption and childhood asthma: a cross-sectional study of the 
      NHANES database.
PG  - 84
LID - 10.1186/s12887-024-04540-5 [doi]
LID - 84
AB  - BACKGROUND: Dietary intakes of vitamins are associated with asthma. However, 
      previous studies mainly explored the association between a single vitamin intake 
      and asthma, which did not take the multivitamins into consideration. Herein, this 
      study aims to explore the overall effect of dietary multivitamins consumption on 
      childhood asthma. METHODS: Data of children and adolescents (aged 2-17 years old) 
      were extracted from the National Health and Nutrition Examination Survey (NHANES) 
      database in 2015-2018 in this cross-sectional study. Weighted univariate logistic 
      regression analysis was used to screen covariates. The association between 
      multivitamins (including vitamin A, C, D, E, B1, B2, B6, B12, K, niacin, folic 
      acid, and choline) and childhood asthma was explored using univariate and 
      multivariate logistic regression analyses. The evaluation indexes were odds ratio 
      (OR) and 95% confidence interval (CI). We further introduced the Bayesian kernel 
      machine regression (BKMR) to assess the joint effect of the twelve vitamins on 
      childhood asthma, the impact of an individual vitamin as part of a vitamin 
      mixture, and the potential interactions among different vitamins. RESULTS: Among 
      4,715 eligible children and adolescents, 487 (10.3%) had asthma. After adjusting 
      for covariates including race, family history of asthma, pregnant smoking, BMI 
      Z-score, energy intake, breast feeding, and low birth weight, we found that for 
      each 1-unit increase in vitamin K consumption, the odds of childhood asthma 
      decreased 0.99 (P=0.028). The overall effect analysis reported a trend of 
      negative relationship between the multivitamins and childhood asthma, especially 
      at the 75th percentile and over. According to the BKMR models, when other 
      vitamins are fixed at the median level, the odds of childhood asthma increased 
      along with the elevated vitamin D (VD) and vitamin B2 (VB2), whereas along with 
      the depressed vitamin C (VC). In addition, no potential interaction has been 
      found between every two vitamins of multivitamins on childhood asthma. 
      CONCLUSION: Among children and adolescents who have high-risk of asthma, it may 
      be beneficial to increase dietary consumption of multivitamins. Our findings 
      recommended that children and adolescents should increase the intake of VC-rich 
      foods, whereas control the dietary consumption of VD and VB2 in daily life.
CI  - (c) 2024. The Author(s).
FAU - Zhang, Li
AU  - Zhang L
AD  - Department of Pediatrics, Women and Children's Hospital of Chongqing Medical 
      University, Chongqing, 401147, P.R. China.
FAU - Xu, Yali
AU  - Xu Y
AD  - Department of Pediatric Center, The Third Affiliated Hospital of Chongqing 
      Medical University, Chongqing, 401120, P.R. China.
FAU - Li, Xuemei
AU  - Li X
AD  - Department of Pediatrics, Women and Children's Hospital of Chongqing Medical 
      University, Chongqing, 401147, P.R. China.
FAU - Yang, Fan
AU  - Yang F
AD  - Department of Pediatrics, The Fifth People's Hospital of Chongqing, No.24 Renji 
      Road, Nanan District, Chongqing, 400062, P.R. China.
FAU - Wang, Chengxiu
AU  - Wang C
AD  - Department of Pediatrics, The Fifth People's Hospital of Chongqing, No.24 Renji 
      Road, Nanan District, Chongqing, 400062, P.R. China.
FAU - Yu, Chunmei
AU  - Yu C
AD  - Department of Pediatrics, The Fifth People's Hospital of Chongqing, No.24 Renji 
      Road, Nanan District, Chongqing, 400062, P.R. China. springmayy@outlook.com.
LA  - eng
PT  - Journal Article
DEP - 20240131
PL  - England
TA  - BMC Pediatr
JT  - BMC pediatrics
JID - 100967804
RN  - 0 (Vitamins)
RN  - 11103-57-4 (Vitamin A)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Pregnancy
MH  - Child
MH  - Female
MH  - Adolescent
MH  - Humans
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Nutrition Surveys
MH  - Bayes Theorem
MH  - *Vitamins
MH  - Vitamin A
MH  - Ascorbic Acid
MH  - *Asthma/epidemiology/etiology
PMC - PMC10829257
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Childhood asthma
OT  - Dietary
OT  - Multivitamin
OT  - NHANES
COIS- The authors declare that they have no competing interests.
EDAT- 2024/02/01 00:42
MHDA- 2024/02/02 06:43
PMCR- 2024/01/31
CRDT- 2024/01/31 23:43
PHST- 2023/05/29 00:00 [received]
PHST- 2024/01/05 00:00 [accepted]
PHST- 2024/02/02 06:43 [medline]
PHST- 2024/02/01 00:42 [pubmed]
PHST- 2024/01/31 23:43 [entrez]
PHST- 2024/01/31 00:00 [pmc-release]
AID - 10.1186/s12887-024-04540-5 [pii]
AID - 4540 [pii]
AID - 10.1186/s12887-024-04540-5 [doi]
PST - epublish
SO  - BMC Pediatr. 2024 Jan 31;24(1):84. doi: 10.1186/s12887-024-04540-5.