PMID- 38298135
OWN - NLM
STAT- Publisher
LR  - 20240201
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
DP  - 2024 Jan 31
TI  - Fulminant type 1 diabetes caused by DIHS could be affected by the reactivation of 
      HHV-6.
LID - dgae058 [pii]
LID - 10.1210/clinem/dgae058 [doi]
AB  - CONTEXT: In the previous issue of this journal, we reported that the incidence of 
      fulminant type 1 diabetes (FT1D) due to the drug-induced hypersensitivity 
      syndrome (DIHS) in Japan is higher than that in the general population and is 
      associated with HLAB62. On the other hand, the reactivation of human herpesvirus 
      6 (HHV-6), which has been reported to be associated with DIHS, was observed at a 
      higher frequency, but its association with the development of FT1D was unclear. 
      OBJECTIVE: We aimed to clarify the relationship between the onset of FT1D and the 
      reactivation of HHV-6. METHODS: We conducted a literature search for cases of 
      DIHS-induced FT1D in addition to previously reported cases, and investigated the 
      changes in the HHV-6 antibody titer before and after the onset of FT1D. RESULTS: 
      The HHV-6 antibody titer was increased just before or after the onset of FT1D in 
      all 8 cases. In one case, HHV-6 DNA was also identified shortly before the onset 
      of FT1D. CONCLUSION: These results indicate for the first time that the 
      reactivation of HHV-6 is associated with the onset of FT1D caused by DIHS.　.
CI  - (c) The Author(s) 2024. Published by Oxford University Press on behalf of the 
      Endocrine Society. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Makino, Hideichi
AU  - Makino H
AD  - Department of Diabetes and Molecular Genetics, Ehime University Graduate School 
      of Medicine, Ehime, Japan.
FAU - Tohyama, Mikiko
AU  - Tohyama M
AD  - Department of Dermatology, National Hospital Organization Shikoku Cancer Center, 
      Ehime, Japan.
FAU - Kawamura, Ryoichi
AU  - Kawamura R
AD  - Department of Diabetes and Molecular Genetics, Ehime University Graduate School 
      of Medicine, Ehime, Japan.
FAU - Takata, Yasunori
AU  - Takata Y
AD  - Department of Diabetes and Molecular Genetics, Ehime University Graduate School 
      of Medicine, Ehime, Japan.
FAU - Osawa, Haruhiko
AU  - Osawa H
AUID- ORCID: 0000-0003-0289-8363
AD  - Department of Diabetes and Molecular Genetics, Ehime University Graduate School 
      of Medicine, Ehime, Japan.
FAU - Onuma, Hiroshi
AU  - Onuma H
AUID- ORCID: 0000-0002-6595-7677
AD  - Department of Diabetes and Molecular Genetics, Ehime University Graduate School 
      of Medicine, Ehime, Japan.
LA  - eng
PT  - Journal Article
DEP - 20240131
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
SB  - IM
OTO - NOTNLM
OT  - cytomegalovirus (CMV)
OT  - drug-induced hypersensitivity syndrome (DIHS)
OT  - fulminant type 1 diabetes (FT1D)
OT  - human herpes virus 6 (HHV-6)
OT  - immune reconstitution inflammatory syndrome (IRIS)
EDAT- 2024/02/01 06:42
MHDA- 2024/02/01 06:42
CRDT- 2024/02/01 03:59
PHST- 2023/10/15 00:00 [received]
PHST- 2023/12/29 00:00 [revised]
PHST- 2024/01/26 00:00 [accepted]
PHST- 2024/02/01 06:42 [medline]
PHST- 2024/02/01 06:42 [pubmed]
PHST- 2024/02/01 03:59 [entrez]
AID - 7595532 [pii]
AID - 10.1210/clinem/dgae058 [doi]
PST - aheadofprint
SO  - J Clin Endocrinol Metab. 2024 Jan 31:dgae058. doi: 10.1210/clinem/dgae058.