PMID- 38302516
OWN - NLM
STAT- MEDLINE
DCOM- 20240205
LR  - 20240206
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 14
IP  - 1
DP  - 2024 Feb 1
TI  - Central auditory test performance predicts future neurocognitive function in 
      children living with and without HIV.
PG  - 2712
LID - 10.1038/s41598-024-52380-1 [doi]
LID - 2712
AB  - Tests of the brain's ability to process complex sounds (central auditory tests) 
      correlate with overall measures of neurocognitive performance. In the low- 
      middle-income countries where resources to conduct detailed cognitive testing is 
      limited, tests that assess the central auditory system may provide a novel and 
      useful way to track neurocognitive performance. This could be particularly useful 
      for children living with HIV (CLWH). To evaluate this, we administered central 
      auditory tests to CLWH and children living without HIV and examined whether 
      central auditory tests given early in a child's life could predict later 
      neurocognitive performance. We used a machine learning technique to incorporate 
      factors known to affect performance on neurocognitive tests, such as education. 
      The results show that central auditory tests are useful predictors of 
      neurocognitive performance and perform as well or in some cases better than 
      factors such as education. Central auditory tests may offer an objective way to 
      track neurocognitive performance in CLWH.
CI  - (c) 2024. The Author(s).
FAU - Joseph, Jeff
AU  - Joseph J
AD  - Department of Quantitative Biomedical Sciences, Geisel School of Medicine at 
      Dartmouth, Hanover, NH, USA.
FAU - Niemczak, Christopher
AU  - Niemczak C
AD  - Department of Quantitative Biomedical Sciences, Geisel School of Medicine at 
      Dartmouth, Hanover, NH, USA.
AD  - Space Medicine Innovations Laboratory, Geisel School of Medicine at Dartmouth, 
      Hanover, NH, USA.
AD  - Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
FAU - Lichtenstein, Jonathan
AU  - Lichtenstein J
AD  - Department of Psychiatry, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
AD  - The Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of 
      Medicine at Dartmouth, Hanover, NH, USA.
FAU - Kobrina, Anastasiya
AU  - Kobrina A
AD  - Space Medicine Innovations Laboratory, Geisel School of Medicine at Dartmouth, 
      Hanover, NH, USA.
FAU - Magohe, Albert
AU  - Magohe A
AD  - Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
FAU - Leigh, Samantha
AU  - Leigh S
AD  - Space Medicine Innovations Laboratory, Geisel School of Medicine at Dartmouth, 
      Hanover, NH, USA.
FAU - Ealer, Christin
AU  - Ealer C
AD  - Space Medicine Innovations Laboratory, Geisel School of Medicine at Dartmouth, 
      Hanover, NH, USA.
FAU - Fellows, Abigail
AU  - Fellows A
AD  - Space Medicine Innovations Laboratory, Geisel School of Medicine at Dartmouth, 
      Hanover, NH, USA.
FAU - Reike, Catherine
AU  - Reike C
AD  - Space Medicine Innovations Laboratory, Geisel School of Medicine at Dartmouth, 
      Hanover, NH, USA.
FAU - Massawe, Enica
AU  - Massawe E
AD  - Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
FAU - Gui, Jiang
AU  - Gui J
AD  - Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, 
      Hanover, NH, USA.
FAU - Buckey, Jay C
AU  - Buckey JC
AD  - Department of Quantitative Biomedical Sciences, Geisel School of Medicine at 
      Dartmouth, Hanover, NH, USA. Jay.C.Buckey.Jr@dartmouth.edu.
AD  - Space Medicine Innovations Laboratory, Geisel School of Medicine at Dartmouth, 
      Hanover, NH, USA. Jay.C.Buckey.Jr@dartmouth.edu.
AD  - Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA. 
      Jay.C.Buckey.Jr@dartmouth.edu.
LA  - eng
GR  - R01 DC009972/DC/NIDCD NIH HHS/United States
GR  - 5R01DC009972/NH/NIH HHS/United States
PT  - Journal Article
DEP - 20240201
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Child
MH  - Humans
MH  - *Hearing Tests
MH  - Neuropsychological Tests
MH  - Educational Status
MH  - *HIV Infections/complications/psychology
PMC - PMC10834399
COIS- The authors declare no competing interests.
EDAT- 2024/02/02 00:42
MHDA- 2024/02/05 06:42
PMCR- 2024/02/01
CRDT- 2024/02/01 23:38
PHST- 2023/08/14 00:00 [received]
PHST- 2024/01/18 00:00 [accepted]
PHST- 2024/02/05 06:42 [medline]
PHST- 2024/02/02 00:42 [pubmed]
PHST- 2024/02/01 23:38 [entrez]
PHST- 2024/02/01 00:00 [pmc-release]
AID - 10.1038/s41598-024-52380-1 [pii]
AID - 52380 [pii]
AID - 10.1038/s41598-024-52380-1 [doi]
PST - epublish
SO  - Sci Rep. 2024 Feb 1;14(1):2712. doi: 10.1038/s41598-024-52380-1.