PMID- 38302542
OWN - NLM
STAT- MEDLINE
DCOM- 20240205
LR  - 20240206
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 14
IP  - 1
DP  - 2024 Feb 1
TI  - Serum biomarkers in patients with hand-arm vibration injury and in controls.
PG  - 2719
LID - 10.1038/s41598-024-52782-1 [doi]
LID - 2719
AB  - Hand-arm vibration injury is a well-known occupational disorder that affects many 
      workers globally. The diagnosis is based mainly on quantitative psychophysical 
      tests and medical history. Typical manifestations of hand-arm vibration injury 
      entail episodes of finger blanching, Raynaud's phenomenon (RP) and sensorineural 
      symptoms from affected nerve fibres and mechanoreceptors in the skin. Differences 
      in serum levels of 17 different biomarkers between 92 patients with hand-arm 
      vibration injury and 51 controls were analysed. Patients with hand-arm vibration 
      injury entailing RP and sensorineural manifestations showed elevated levels of 
      biomarkers associated with endothelial injury or dysfunction, inflammation, vaso- 
      or neuroprotective compensatory, or apoptotic mechanisms: intercellular adhesion 
      molecule-1 (ICAM-1), monocyte chemoattractant protein-1 (MCP-1); thrombomodulin 
      (TM), heat shock protein 27 (HSP27); von Willebrand factor, calcitonin 
      gene-related peptide (CGRP) and caspase-3. This study adds important knowledge on 
      pathophysiological mechanisms that can contribute to the implementation of a more 
      objective method for diagnosis of hand-arm vibration injury.
CI  - (c) 2024. The Author(s).
FAU - Tekavec, Eva
AU  - Tekavec E
AD  - Division of Occupational and Environmental Medicine, Department of Laboratory 
      Medicine, Lund University, 221 00, Lund, Sweden. eva.tekavec@med.lu.se.
FAU - Nilsson, Tohr
AU  - Nilsson T
AD  - Section of Sustainable Health, Department of Public Health and Clinical Medicine, 
      Umea University, SE-901 87, Umea, Sweden.
FAU - Dahlin, Lars B
AU  - Dahlin LB
AD  - Department of Translational Medicine-Hand Surgery, Lund University, 221 00, Lund, 
      Sweden.
FAU - Huynh, Elizabeth
AU  - Huynh E
AD  - Occupational and Environmental Medicine, Region Skane, 223 63, Lund, Sweden.
FAU - Axmon, Anna
AU  - Axmon A
AD  - Division of Occupational and Environmental Medicine, Department of Laboratory 
      Medicine, Lund University, 221 00, Lund, Sweden.
FAU - Nordander, Catarina
AU  - Nordander C
AD  - Division of Occupational and Environmental Medicine, Department of Laboratory 
      Medicine, Lund University, 221 00, Lund, Sweden.
FAU - Riddar, Jakob
AU  - Riddar J
AD  - Division of Occupational and Environmental Medicine, Department of Laboratory 
      Medicine, Lund University, 221 00, Lund, Sweden.
FAU - Karedal, Monica
AU  - Karedal M
AD  - Division of Occupational and Environmental Medicine, Department of Laboratory 
      Medicine, Lund University, 221 00, Lund, Sweden.
AD  - Occupational and Environmental Medicine, Region Skane, 223 63, Lund, Sweden.
LA  - eng
PT  - Journal Article
DEP - 20240201
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Vibration
MH  - Hand
MH  - Fingers/innervation
MH  - *Occupational Diseases
MH  - *Hand Injuries
MH  - *Arm Injuries
MH  - *Raynaud Disease
MH  - Biomarkers
PMC - PMC10834969
COIS- The authors declare no competing interests.
EDAT- 2024/02/02 00:42
MHDA- 2024/02/05 06:42
PMCR- 2024/02/01
CRDT- 2024/02/01 23:40
PHST- 2023/10/24 00:00 [received]
PHST- 2024/01/23 00:00 [accepted]
PHST- 2024/02/05 06:42 [medline]
PHST- 2024/02/02 00:42 [pubmed]
PHST- 2024/02/01 23:40 [entrez]
PHST- 2024/02/01 00:00 [pmc-release]
AID - 10.1038/s41598-024-52782-1 [pii]
AID - 52782 [pii]
AID - 10.1038/s41598-024-52782-1 [doi]
PST - epublish
SO  - Sci Rep. 2024 Feb 1;14(1):2719. doi: 10.1038/s41598-024-52782-1.