PMID- 38302950
OWN - NLM
STAT- MEDLINE
DCOM- 20240205
LR  - 20240206
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 24
IP  - 1
DP  - 2024 Feb 1
TI  - Predictors of non-obstructive coronary slow flow in poorly controlled type 2 
      diabetes mellitus: a cross-sectional study.
PG  - 83
LID - 10.1186/s12872-024-03738-w [doi]
LID - 83
AB  - BACKGROUND: Coronary slow flow (CSF) can occur due to various factors, such as 
      inflammation, small vessel disease, endothelial dysfunction, and inadequate 
      glucose control. However, the exact pathological mechanisms behind CSF remain 
      incompletely understood. The objective of this study was to identify the risk 
      factors associated with slow coronary flow in individuals with Type 2 Diabetes 
      Mellitus (T2DM) who have non-obstructive coronary artery disease (CAD) and 
      experience CSF. METHODS: We conducted a prospective cohort study involving 120 
      patients with T2DM who were referred for invasive coronary angiography due to 
      typical chest pain or inconclusive results from non-invasive tests for myocardial 
      ischemia. Using a 2 x 2 design, we categorized patients into groups based on 
      their glycemic control (adequate or poor) and the presence of CSF (yes or no), 
      defined by a TIMI frame count > 27. All patients had non-obstructive CAD, 
      characterized by diameter stenosis of less than 40%. We identified many variables 
      associated with CSF. RESULTS: Our investigation revealed no significant 
      differences in age, sex, family history of coronary artery disease, ECG ischemia 
      abnormalities, or echocardiographic (ECHO) data between the groups. In patients 
      with adequate glycemic control, hypertension increased the risk of CSF by 5.33 
      times, smoking by 3.2 times, while dyslipidemia decreased the risk by 0.142. 
      Additionally, hematocrit increased the risk by 2.3, and the 
      platelet-to-lymphocyte ratio (PLR) increased the risk by 1.053. Among patients 
      with poor glycemic control, hematocrit increased the risk by 2.63, and the 
      Neutrophil-to-Lymphocyte Ratio (NLR) by 24.6. Notably, NLR was positively 
      correlated with glycemic control parameters in T2DM patients with CSF. 
      CONCLUSIONS: In T2DM patients with CSF, various factors strongly correlate with 
      glycemic control parameters and can be employed to predict the likelihood of CSF. 
      These factors encompass hypertension, smoking, increased body mass index (BMI), 
      elevated platelet count, hematocrit, NLR, PLR, and C-reactive protein (CRP). 
      TRIAL REGISTRATION: Registry: ZU-IRB (ZU-IRB#9419-3-4-2022), Registered on: 3 
      April 2022, Email: IRB_123@medicine.zu.edu.eg.
CI  - (c) 2024. The Author(s).
FAU - Elsanan, Moataz Ali Hasan Ali
AU  - Elsanan MAHA
AUID- ORCID: 0000-0002-8672-3159
AD  - Department of Cardiology, Faculty of Medicine, Zagazig University, Sharkia 
      Governorate, Zagazig, 44519, Egypt.
FAU - Tahoon, Islam Hussein Hassan Hussein
AU  - Tahoon IHHH
AUID- ORCID: 0000-0002-6676-149X
AD  - Department of Cardiology, Faculty of Medicine, Zagazig University, Sharkia 
      Governorate, Zagazig, 44519, Egypt.
FAU - Mohamed, Ghada Ibrahim
AU  - Mohamed GI
AUID- ORCID: 0000-0001-5016-9021
AD  - Department of Cardiology, Faculty of Medicine, Zagazig University, Sharkia 
      Governorate, Zagazig, 44519, Egypt.
FAU - El-Dosouky, Ibtesam Ibrahim
AU  - El-Dosouky II
AUID- ORCID: 0000-0003-4385-5458
AD  - Department of Cardiology, Faculty of Medicine, Zagazig University, Sharkia 
      Governorate, Zagazig, 44519, Egypt.
FAU - Shehata, Islam Elsayed
AU  - Shehata IE
AUID- ORCID: 0000-0002-3850-9027
AD  - Department of Cardiology, Faculty of Medicine, Zagazig University, Sharkia 
      Governorate, Zagazig, 44519, Egypt. iemshehata@zu.edu.eg.
LA  - eng
PT  - Journal Article
DEP - 20240201
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
SB  - IM
MH  - Humans
MH  - *Coronary Artery Disease/diagnostic imaging/complications
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis
MH  - Cross-Sectional Studies
MH  - Prospective Studies
MH  - Coronary Angiography
MH  - *Hypertension/complications
PMC - PMC10832194
OTO - NOTNLM
OT  - Coronary artery disease
OT  - Coronary slow flow
OT  - Diabetes mellitus
OT  - Neutrophil-to-lymphocyte ratio (NLR)
OT  - TIMI flow
COIS- The authors declare no competing interests.
EDAT- 2024/02/02 06:43
MHDA- 2024/02/05 06:42
PMCR- 2024/02/01
CRDT- 2024/02/02 00:04
PHST- 2023/06/26 00:00 [received]
PHST- 2024/01/18 00:00 [accepted]
PHST- 2024/02/05 06:42 [medline]
PHST- 2024/02/02 06:43 [pubmed]
PHST- 2024/02/02 00:04 [entrez]
PHST- 2024/02/01 00:00 [pmc-release]
AID - 10.1186/s12872-024-03738-w [pii]
AID - 3738 [pii]
AID - 10.1186/s12872-024-03738-w [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2024 Feb 1;24(1):83. doi: 10.1186/s12872-024-03738-w.