PMID- 38304726
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240203
IS  - 2352-9067 (Print)
IS  - 2352-9067 (Electronic)
IS  - 2352-9067 (Linking)
VI  - 50
DP  - 2024 Feb
TI  - The safety and efficacy of compression therapy in patients with stable heart 
      failure.
PG  - 101343
LID - 10.1016/j.ijcha.2024.101343 [doi]
LID - 101343
AB  - BACKGROUND: Compression therapy is widely used as a therapeutic option for edema; 
      however, concerns regarding its safety in patients with heart failure (HF) arose, 
      particularly due to increased venous return, which increases pulmonary artery 
      blood pressure. This study aimed to investigate the safety of compression therapy 
      in patients with chronic HF. METHODS: This study retrospectively enrolled 
      patients with stable chronic HF who initiated treatment with compression therapy 
      for lower extremity edema. The primary outcome was New York Heart Association 
      (NYHA) class changes after 1 month of compression therapy, and adverse events 
      were evaluated. RESULTS: We analyzed 101 patients who initiated compression 
      therapy. The number of patients continuing compression therapy at one month was 
      86. Overall, 61.6 % were female and the median age was 81 years. The proportion 
      of patients with heart failure and preserved ejection fraction (HFpEF) was 
      50.4 %. Brain natriuretic peptide levels were significantly lower than baseline 
      levels at 1 month, (baseline vs 1 month: 486 (360-696) vs 311 (211-511), 
      p < 0.001), with a lower NYHA III prevalence (baseline vs 1 month: 53.5 % vs 
      32.6 %, p < 0.001), without any adverse events related to compression therapy 
      initiation. Additionally, multivariate logistic analysis indicated an association 
      between HFpEF and significant BNP reduction after compression therapy (odds 
      ratio: 4.70; 95 % confidence interval: 1.63-13.6). CONCLUSIONS: Compression 
      therapy was associated with decreased BNP levels and improved symptoms, 
      especially in HFpEF, without any adverse events in stable chronic HF. These 
      findings indicate that compression therapy is safe for patients with stable 
      chronic HF.
CI  - (c) 2024 The Authors.
FAU - Nasu, Takahito
AU  - Nasu T
AD  - Division of Cardiology, Department of Internal Medicine, Iwate Medical 
      University, Iwate, Japan.
AD  - Department of Biomedical Information Analysis, Institute for Biomedical Sciences, 
      Iwate Medical University, Iwate, Japan.
FAU - Matsumoto, Shingo
AU  - Matsumoto S
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Toho 
      University Faculty of Medicine, Tokyo, Japan.
FAU - Fujimoto, Wataru
AU  - Fujimoto W
AD  - Department of Cardiology, Hyogo Prefectural Awaji Medical Center, Hyogo, Japan.
FAU - Numazaki, Harutomo
AU  - Numazaki H
AD  - Division of Cardiology, Department of Internal Medicine, Iwate Medical 
      University, Iwate, Japan.
FAU - Morino, Yoshihiro
AU  - Morino Y
AD  - Division of Cardiology, Department of Internal Medicine, Iwate Medical 
      University, Iwate, Japan.
LA  - eng
PT  - Journal Article
DEP - 20240121
PL  - Ireland
TA  - Int J Cardiol Heart Vasc
JT  - International journal of cardiology. Heart & vasculature
JID - 101649525
PMC - PMC10830501
OTO - NOTNLM
OT  - Leg compression therapy
OT  - Lymphatic dysfunction
OT  - Venous dysfunction
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2024/02/02 06:42
MHDA- 2024/02/02 06:43
PMCR- 2024/01/21
CRDT- 2024/02/02 04:11
PHST- 2023/10/26 00:00 [received]
PHST- 2024/01/05 00:00 [revised]
PHST- 2024/01/12 00:00 [accepted]
PHST- 2024/02/02 06:43 [medline]
PHST- 2024/02/02 06:42 [pubmed]
PHST- 2024/02/02 04:11 [entrez]
PHST- 2024/01/21 00:00 [pmc-release]
AID - S2352-9067(24)00009-5 [pii]
AID - 101343 [pii]
AID - 10.1016/j.ijcha.2024.101343 [doi]
PST - epublish
SO  - Int J Cardiol Heart Vasc. 2024 Jan 21;50:101343. doi: 
      10.1016/j.ijcha.2024.101343. eCollection 2024 Feb.