PMID- 38304867
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240203
IS  - 2296-2646 (Print)
IS  - 2296-2646 (Electronic)
IS  - 2296-2646 (Linking)
VI  - 12
DP  - 2024
TI  - Stimuli-responsive hydrogel based on natural polymers for breast cancer.
PG  - 1325204
LID - 10.3389/fchem.2024.1325204 [doi]
LID - 1325204
AB  - Aims: Breast cancer is the most common malignancy among women in both high- and 
      low-resource settings. Conventional breast cancer therapies were inefficient and 
      had low patient compliance. Stimuli-responsive hydrogels possessing similar 
      physicochemical features as soft tissue facilitate diagnostic and therapeutic 
      approaches for breast cancer subtypes. Scope: Polysaccharides and polypeptides 
      are major natural polymers with unique biocompatibility, biodegradability, and 
      feasible modification approaches utilized frequently for hydrogel fabrication. 
      Alternating the natural polymer-based hydrogel properties in response to external 
      stimuli such as pH, temperature, light, ultrasonic, enzyme, glucose, magnetic, 
      redox, and electric have provided great potential for the evolution of novel drug 
      delivery systems (DDSs) and various advanced technologies in medical 
      applications. Stimuli-responsive hydrogels are triggered by specific cancer 
      tissue features, promote target delivery techniques, and modify release 
      therapeutic agents at localized sites. This narrative review presented innovation 
      in preparing and characterizing the most common stimuli-responsive natural 
      polymer-based hydrogels for diagnostic and therapeutic applications in the breast 
      cancer area. Conclusion: Stimuli-responsive hydrogels display bioinspiration 
      products as DDSs for breast cancer subtypes, protect the shape of breast tissue, 
      provide modified drug release, enhance therapeutic efficacy, and minimize 
      chemotherapy agents' side effects. The potential benefits of smart natural 
      polymer-based hydrogels make them an exciting area of practice for breast cancer 
      diagnosis and treatment.
CI  - Copyright (c) 2024 Asadi, Samiraninezhad, Akbarizadeh, Amini and Gholami.
FAU - Asadi, Khatereh
AU  - Asadi K
AD  - Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, 
      Iran.
AD  - Department of Medical Nanotechnology, School of Advanced Medical Science and 
      Technology, Shiraz University of Medical Sciences, Shiraz, Iran.
AD  - Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, 
      Iran.
FAU - Samiraninezhad, Nazafarin
AU  - Samiraninezhad N
AD  - Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, 
      Iran.
FAU - Akbarizadeh, Amin Reza
AU  - Akbarizadeh AR
AD  - Department of Quality Control, Faculty of Pharmacy, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Amini, Abbas
AU  - Amini A
AD  - Abdullah Al Salem University (AASU), College of Engineering and Energy, Khaldiya, 
      Kuwait.
AD  - Centre for Infrastructure Engineering, Western Sydney University, Penrith, NSW, 
      Australia.
FAU - Gholami, Ahmad
AU  - Gholami A
AD  - Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, 
      Iran.
AD  - Department of Medical Nanotechnology, School of Advanced Medical Science and 
      Technology, Shiraz University of Medical Sciences, Shiraz, Iran.
AD  - Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University 
      of Medical Sciences, Shiraz, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240118
PL  - Switzerland
TA  - Front Chem
JT  - Frontiers in chemistry
JID - 101627988
PMC - PMC10830687
OTO - NOTNLM
OT  - breast cancer
OT  - chemotherapy
OT  - drug delivery
OT  - hydrogel
OT  - nanogel
OT  - natural polymer
OT  - smart
OT  - stimuli-responsive
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/02/02 06:42
MHDA- 2024/02/02 06:43
PMCR- 2024/01/01
CRDT- 2024/02/02 04:15
PHST- 2023/10/20 00:00 [received]
PHST- 2024/01/04 00:00 [accepted]
PHST- 2024/02/02 06:43 [medline]
PHST- 2024/02/02 06:42 [pubmed]
PHST- 2024/02/02 04:15 [entrez]
PHST- 2024/01/01 00:00 [pmc-release]
AID - 1325204 [pii]
AID - 10.3389/fchem.2024.1325204 [doi]
PST - epublish
SO  - Front Chem. 2024 Jan 18;12:1325204. doi: 10.3389/fchem.2024.1325204. eCollection 
      2024.