PMID- 38305576
OWN - NLM
STAT- MEDLINE
DCOM- 20240215
LR  - 20240215
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 12
IP  - 7
DP  - 2024 Feb 14
TI  - Injectable and self-healable nano-architectured hydrogel for NIR-light responsive 
      chemo- and photothermal bacterial eradication.
PG  - 1905-1925
LID - 10.1039/d3tb02693k [doi]
AB  - Hydrogels with multifunctional properties activated at specific times have gained 
      significant attention in the biomedical field. As bacterial infections can cause 
      severe complications that negatively impact wound repair, herein, we present the 
      development of a stimuli-responsive, injectable, and in situ-forming hydrogel 
      with antibacterial, self-healing, and drug-delivery properties. In this study, we 
      prepared a Pluronic F-127 (PF127) and sodium alginate (SA)-based hydrogel that 
      can be targeted to a specific tissue via injection. The PF127/SA hydrogel was 
      incorporated with polymeric short-filaments (SFs) containing an anti-inflammatory 
      drug - ketoprofen, and stimuli-responsive polydopamine (PDA) particles. The 
      hydrogel, after injection, could be in situ gelated at the body temperature, 
      showing great in vitro stability and self-healing ability after 4 h of 
      incubation. The SFs and PDA improved the hydrogel injectability and compressive 
      strength. The introduction of PDA significantly accelerated the KET release under 
      near-infrared light exposure and extended its release validity period. The 
      excellent composites' photo-thermal performance led to antibacterial activity 
      against representative Gram-positive and Gram-negative bacteria, resulting in 
      99.9% E. coli and S. aureus eradication after 10 min of NIR light irradiation. In 
      vitro, fibroblast L929 cell studies confirmed the materials' biocompatibility and 
      paved the way toward further in vivo and clinical application of the system for 
      chronic wound treatments.
FAU - Rybak, Daniel
AU  - Rybak D
AD  - Department of Biosystems and Soft Matter, Institute of Fundamental Technological 
      Research, Polish Academy of Sciences, Warsaw 02-106, Poland. 
      fpierini@ippt.pan.pl.
FAU - Rinoldi, Chiara
AU  - Rinoldi C
AD  - Department of Biosystems and Soft Matter, Institute of Fundamental Technological 
      Research, Polish Academy of Sciences, Warsaw 02-106, Poland. 
      fpierini@ippt.pan.pl.
FAU - Nakielski, Pawel
AU  - Nakielski P
AUID- ORCID: 0000-0001-6194-701X
AD  - Department of Biosystems and Soft Matter, Institute of Fundamental Technological 
      Research, Polish Academy of Sciences, Warsaw 02-106, Poland. 
      fpierini@ippt.pan.pl.
FAU - Du, Jingtao
AU  - Du J
AD  - Innovation Center for Textile Science and Technology, Collage of Textiles, 
      Donghua University, Shanghai 201620, China.
FAU - Haghighat Bayan, Mohammad Ali
AU  - Haghighat Bayan MA
AUID- ORCID: 0000-0003-2912-7163
AD  - Department of Biosystems and Soft Matter, Institute of Fundamental Technological 
      Research, Polish Academy of Sciences, Warsaw 02-106, Poland. 
      fpierini@ippt.pan.pl.
FAU - Zargarian, Seyed Shahrooz
AU  - Zargarian SS
AD  - Department of Biosystems and Soft Matter, Institute of Fundamental Technological 
      Research, Polish Academy of Sciences, Warsaw 02-106, Poland. 
      fpierini@ippt.pan.pl.
FAU - Pruchniewski, Michal
AU  - Pruchniewski M
AUID- ORCID: 0000-0003-1511-584X
AD  - Department of Nanobiotechnology, Institute of Biology, Warsaw University of Life 
      Sciences, Warsaw 02-787, Poland.
FAU - Li, Xiaoran
AU  - Li X
AUID- ORCID: 0000-0002-6675-8709
AD  - Innovation Center for Textile Science and Technology, Collage of Textiles, 
      Donghua University, Shanghai 201620, China.
FAU - Strojny-Cieslak, Barbara
AU  - Strojny-Cieslak B
AD  - Department of Nanobiotechnology, Institute of Biology, Warsaw University of Life 
      Sciences, Warsaw 02-787, Poland.
FAU - Ding, Bin
AU  - Ding B
AUID- ORCID: 0000-0003-1499-2154
AD  - Innovation Center for Textile Science and Technology, Collage of Textiles, 
      Donghua University, Shanghai 201620, China.
FAU - Pierini, Filippo
AU  - Pierini F
AUID- ORCID: 0000-0002-6526-4141
AD  - Department of Biosystems and Soft Matter, Institute of Fundamental Technological 
      Research, Polish Academy of Sciences, Warsaw 02-106, Poland. 
      fpierini@ippt.pan.pl.
LA  - eng
PT  - Journal Article
DEP - 20240214
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Hydrogels)
SB  - IM
MH  - *Anti-Bacterial Agents/pharmacology
MH  - *Hydrogels/pharmacology
MH  - Staphylococcus aureus
MH  - Escherichia coli
MH  - Gram-Negative Bacteria
MH  - Gram-Positive Bacteria
EDAT- 2024/02/02 12:43
MHDA- 2024/02/15 06:43
CRDT- 2024/02/02 09:37
PHST- 2024/02/15 06:43 [medline]
PHST- 2024/02/02 12:43 [pubmed]
PHST- 2024/02/02 09:37 [entrez]
AID - 10.1039/d3tb02693k [doi]
PST - epublish
SO  - J Mater Chem B. 2024 Feb 14;12(7):1905-1925. doi: 10.1039/d3tb02693k.