PMID- 38306363 OWN - NLM STAT- MEDLINE DCOM- 20240205 LR - 20240206 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 19 IP - 2 DP - 2024 TI - The effectiveness of diabetes self-management education intervention on glycaemic control and cardiometabolic risk in adults with type 2 diabetes in low- and middle-income countries: A systematic review and meta-analysis. PG - e0297328 LID - 10.1371/journal.pone.0297328 [doi] LID - e0297328 AB - Diabetes mellitus (DM) poses a significant challenge to public health. Effective diabetes self-management education (DSME) interventions may play a pivotal role in the care of people with type 2 diabetes mellitus (T2DM) in low- and middle-income countries (LMICs). A specific up-to-date systematic review is needed to assess the effect of DSME interventions on glycaemic control, cardiometabolic risk, self-management behaviours, and psychosocial well-being among T2DM across LMICs. The MEDLINE, Embase, CINAHL, Global Health, and Cochrane databases were searched on 02 August 2022 and then updated on 10 November 2023 for published randomised controlled trials (RCTs) and quasi-experimental studies. The quality of the studies was assessed, and a random-effect model was used to estimate the pooled effect of diabetes DSME intervention. Heterogeneity (I2) was tested, and subgroup analyses were performed. Egger's regression test and funnel plots were used to examine publication bias. The risk of bias of the included studies was assessed using the Cochrane risk-of-bias tool for randomized trial (RoB 2). The overall assessment of the evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation approach. A total of 5893 articles were retrieved, and 44 studies (n = 11838) from 21 LMICs met the inclusion criteria. Compared with standard care, pooled analysis showed that DSME effectively reduced the HbA1c level by 0.64% (95% CI: 0.45% to 0.83%) and 1.27% (95% CI: -0.63% to 3.17%) for RCTs and quasi-experimental design studies, respectively. Further, the findings showed an improvement in cardiometabolic risk reduction, diabetes self-management behaviours, and psychosocial well-being. This review suggests that ongoing support alongside individualised face-to-face intervention delivery is favourable for improving overall T2DM management in LMICs, with a special emphasis on countries in the lowest income group. CI - Copyright: (c) 2024 Chowdhury et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Chowdhury, Hasina Akhter AU - Chowdhury HA AUID- ORCID: 0000-0001-7912-8303 AD - Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. AD - Centre for Injury Prevention and Research, Bangladesh (CIPRB), Dhaka, Bangladesh. FAU - Harrison, Cheryce L AU - Harrison CL AD - Monash Centre for Health Research and Implementation-MCHRI, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. FAU - Siddiquea, Bodrun Naher AU - Siddiquea BN AD - Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. FAU - Tissera, Sanuki AU - Tissera S AD - Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. FAU - Afroz, Afsana AU - Afroz A AD - Department of Biochemistry and Pharmacology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Australia. FAU - Ali, Liaquat AU - Ali L AD - Pothikrit Institute of Health Studies (PIHS), Dhaka, Bangladesh. FAU - Joham, Anju E AU - Joham AE AD - Monash Centre for Health Research and Implementation-MCHRI, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. AD - Departments of Endocrinology and Diabetes, Monash Health, Melbourne, Australia. FAU - Billah, Baki AU - Billah B AD - Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20240202 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adult MH - Humans MH - Developing Countries MH - Glycemic Control MH - *Self-Management MH - *Diabetes Mellitus, Type 2/complications/therapy/psychology MH - *Cardiovascular Diseases/epidemiology/prevention & control PMC - PMC10836683 COIS- The authors have declared that no competing interests exist. EDAT- 2024/02/02 18:42 MHDA- 2024/02/05 06:43 PMCR- 2024/02/02 CRDT- 2024/02/02 13:35 PHST- 2023/07/11 00:00 [received] PHST- 2024/01/01 00:00 [accepted] PHST- 2024/02/05 06:43 [medline] PHST- 2024/02/02 18:42 [pubmed] PHST- 2024/02/02 13:35 [entrez] PHST- 2024/02/02 00:00 [pmc-release] AID - PONE-D-23-21626 [pii] AID - 10.1371/journal.pone.0297328 [doi] PST - epublish SO - PLoS One. 2024 Feb 2;19(2):e0297328. doi: 10.1371/journal.pone.0297328. eCollection 2024.