PMID- 38307451
OWN - NLM
STAT- MEDLINE
DCOM- 20240219
LR  - 20240322
IS  - 1095-8541 (Electronic)
IS  - 0022-5193 (Linking)
VI  - 581
DP  - 2024 Mar 21
TI  - A mathematical model of obesity-induced type 2 diabetes and efficacy of 
      anti-diabetic weight reducing drug.
PG  - 111756
LID - S0022-5193(24)00037-7 [pii]
LID - 10.1016/j.jtbi.2024.111756 [doi]
AB  - The dominant paradigm for modeling the obesity-induced T2DM (type 2 diabetes 
      mellitus) today focuses on glucose and insulin regulatory systems, diabetes 
      pathways, and diagnostic test evaluations. The problem with this approach is that 
      it is not possible to explicitly account for the glucose transport mechanism from 
      the blood to the liver, where the glucose is stored, and from the liver to the 
      blood. This makes it inaccurate, if not incorrect, to properly model the 
      concentration of glucose in the blood in comparison to actual glycated hemoglobin 
      (A1C) test results. In this paper, we develop a mathematical model of glucose 
      dynamics by a system of ODEs. The model includes the mechanism of glucose 
      transport from the blood to the liver, and from the liver to the blood, and 
      explains how obesity is likely to lead to T2DM. We use the model to evaluate the 
      efficacy of an anti-T2DM drug that also reduces weight.
CI  - Copyright (c) 2024 Elsevier Ltd. All rights reserved.
FAU - Siewe, Nourridine
AU  - Siewe N
AD  - School of Mathematics and Statistics, College of Science, Rochester Institute of 
      Technology, Rochester, NY, USA. Electronic address: nourridine@aims.ac.za.
FAU - Friedman, Avner
AU  - Friedman A
AD  - Department of Mathematics, The Ohio State University, Columbus, OH, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20240201
PL  - England
TA  - J Theor Biol
JT  - Journal of theoretical biology
JID - 0376342
RN  - 0 (Blood Glucose)
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy
MH  - Blood Glucose/metabolism
MH  - Glucose
MH  - Insulin/metabolism
MH  - Obesity/complications/drug therapy
MH  - Models, Theoretical
OTO - NOTNLM
OT  - A1C
OT  - GLUT-2/GLUT-4
OT  - GPL-1
OT  - Glucose
OT  - Insulin
OT  - Mounjaro
OT  - Type 2 diabetes
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/02/03 00:42
MHDA- 2024/02/19 06:42
CRDT- 2024/02/02 19:34
PHST- 2023/08/17 00:00 [received]
PHST- 2023/11/04 00:00 [revised]
PHST- 2024/01/26 00:00 [accepted]
PHST- 2024/02/19 06:42 [medline]
PHST- 2024/02/03 00:42 [pubmed]
PHST- 2024/02/02 19:34 [entrez]
AID - S0022-5193(24)00037-7 [pii]
AID - 10.1016/j.jtbi.2024.111756 [doi]
PST - ppublish
SO  - J Theor Biol. 2024 Mar 21;581:111756. doi: 10.1016/j.jtbi.2024.111756. Epub 2024 
      Feb 1.