PMID- 38307981
OWN - NLM
STAT- MEDLINE
DCOM- 20240205
LR  - 20240206
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 14
IP  - 1
DP  - 2024 Feb 2
TI  - Effects of mouthwash on periodontal pathogens and glycemic control in patients 
      with type 2 diabetes mellitus.
PG  - 2777
LID - 10.1038/s41598-024-53213-x [doi]
LID - 2777
AB  - Periodontitis is known to be associated with type 2 diabetes mellitus (T2DM), and 
      gargling with mouthwash is known to reduce the incidence of periodontitis by 
      inhibiting periodontal pathogens. However, the effects of mouthwash on oral and 
      systemic conditions in patients with T2DM remain unknown. In this study, we 
      investigated the effects of gargling with mouthwash on the number of red complex 
      species, including Porphyromonas gingivalis, Treponema denticola, and Tannerella 
      forsythia, and HbA1c levels in patients with T2DM. Patients were instructed to 
      gargle with water for 6 months, followed by gargling with mouthwash containing 
      chlorhexidine gluconate for the subsequent 6 months. At each clinic visit, saliva 
      was collected and bacterial DNA was extracted to detect red complex species using 
      the polymerase chain reaction technique. The HbA1c level was determined using a 
      blood sample. The number of red complex species significantly decreased in 
      younger or male patients who gargled with mouthwash. Furthermore, HbA1c levels 
      significantly decreased in younger patients or patients with higher HbA1c levels 
      who gargled with mouthwash. These results suggest that gargling with mouthwash 
      reduces the number of red complex species and improves the hyperglycemic status 
      in patients with T2DM, especially younger patients.
CI  - (c) 2024. The Author(s).
FAU - Matayoshi, Saaya
AU  - Matayoshi S
AD  - Joint Research Laboratory of Science for Oral and Systemic Connection, Osaka 
      University Graduate School of Dentistry, 1-8 Yamada-Oka, Suita, Osaka, 565-0871, 
      Japan. matayoshi.saaya.dent@osaka-u.ac.jp.
FAU - Tojo, Fumikazu
AU  - Tojo F
AD  - Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, 
      Osaka, Japan.
FAU - Suehiro, Yuto
AU  - Suehiro Y
AD  - Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, 
      Osaka, Japan.
FAU - Okuda, Makoto
AU  - Okuda M
AD  - Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, 
      Osaka, Japan.
FAU - Takagi, Misato
AU  - Takagi M
AD  - Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, 
      Osaka, Japan.
FAU - Ochiai, Marin
AU  - Ochiai M
AD  - Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, 
      Osaka, Japan.
FAU - Kadono, Maika
AU  - Kadono M
AD  - Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, 
      Osaka, Japan.
FAU - Mikasa, Yusuke
AU  - Mikasa Y
AD  - Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, 
      Osaka, Japan.
FAU - Okawa, Rena
AU  - Okawa R
AD  - Joint Research Laboratory of Science for Oral and Systemic Connection, Osaka 
      University Graduate School of Dentistry, 1-8 Yamada-Oka, Suita, Osaka, 565-0871, 
      Japan.
AD  - Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, 
      Osaka, Japan.
FAU - Nomura, Ryota
AU  - Nomura R
AD  - Department of Pediatric Dentistry, Hiroshima University Graduate School of 
      Biomedical and Health Sciences, Hiroshima, Japan.
FAU - Itoh, Yoshito
AU  - Itoh Y
AD  - Itoh Internal Medicine Clinic, Osaka, Japan.
AD  - Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, Japan.
FAU - Itoh, Naoto
AU  - Itoh N
AD  - Joint Research Laboratory of Science for Oral and Systemic Connection, Osaka 
      University Graduate School of Dentistry, 1-8 Yamada-Oka, Suita, Osaka, 565-0871, 
      Japan.
AD  - Itoh Internal Medicine Clinic, Osaka, Japan.
FAU - Nakano, Kazuhiko
AU  - Nakano K
AD  - Joint Research Laboratory of Science for Oral and Systemic Connection, Osaka 
      University Graduate School of Dentistry, 1-8 Yamada-Oka, Suita, Osaka, 565-0871, 
      Japan.
AD  - Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, 
      Osaka, Japan.
LA  - eng
PT  - Journal Article
DEP - 20240202
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Mouthwashes)
RN  - 0 (Glycated Hemoglobin)
SB  - IM
MH  - Humans
MH  - Male
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Mouthwashes/therapeutic use
MH  - Glycated Hemoglobin
MH  - Glycemic Control
MH  - Porphyromonas gingivalis/genetics
MH  - *Periodontitis/microbiology
PMC - PMC10837110
COIS- The authors declare no competing interests.
EDAT- 2024/02/03 00:42
MHDA- 2024/02/05 06:43
PMCR- 2024/02/02
CRDT- 2024/02/02 23:42
PHST- 2023/08/15 00:00 [received]
PHST- 2024/01/29 00:00 [accepted]
PHST- 2024/02/05 06:43 [medline]
PHST- 2024/02/03 00:42 [pubmed]
PHST- 2024/02/02 23:42 [entrez]
PHST- 2024/02/02 00:00 [pmc-release]
AID - 10.1038/s41598-024-53213-x [pii]
AID - 53213 [pii]
AID - 10.1038/s41598-024-53213-x [doi]
PST - epublish
SO  - Sci Rep. 2024 Feb 2;14(1):2777. doi: 10.1038/s41598-024-53213-x.