PMID- 38308091
OWN - NLM
STAT- Publisher
LR  - 20240202
IS  - 1476-5489 (Electronic)
IS  - 0955-9930 (Linking)
DP  - 2024 Feb 2
TI  - Effect of bulbospongiosus muscle injection with botulinum-A toxin for treatment 
      of lifelong premature ejaculation; a randomized controlled trial.
LID - 10.1038/s41443-024-00831-8 [doi]
AB  - This study aimed at assessing a new line of treatment for lifelong premature 
      ejaculation which is botulinum-A toxin injection into the bulbospongiosus muscle. 
      Sixty patients with lifelong premature ejaculation were independently randomized 
      into 2 groups; group I, 100 U botulinum-A toxin at 10 U/ml saline was injected 
      with ultrasound guidance into the bulbospongiosus muscle and group II which was 
      injected with similar volume of saline. The primary outcome was to compare both 
      groups for changes in the Premature Ejaculation Profile (PEP), Intravaginal 
      Ejaculatory Latency Time (IELT) and partner's satisfaction at 1, 3 and 6 months 
      after intervention. The second outcome was to compare the adverse events in both 
      groups. Fifty-seven patients completed the study. In group I, the mean PEP 
      increased significantly at 1- (P = 0.02) and 3- months (P = 0.04) with 
      insignificant increase at 6-month (P = 0.6) of follow-up. Also, no significant 
      changes had been noted in IELT or partner's satisfaction scores throughout the 
      study duration (P > 0.05). In group II, no significant changes had been noted in 
      the PEP, IELT and partner's satisfaction scores throughout the study duration 
      (P > 0.05). There were insignificant differences in the changes in the mean PEP 
      (P = 0.7, 0.6 and 0.4), IELT (P = 0.6,0.6 and 0.5) and partner's satisfaction 
      scores (P = 0.5,0.7 and 0.3) in comparison to the baseline values at 1-, 3- and 
      6- months, respectively between both groups. Adverse events were observed in only 
      3 patients (5.3%). In group I, mild erectile dysfunction and post micturition 
      dribbling were reported in one patient each. Where in group II, one patient 
      reported bleeding per urethra (P = 0.5). To conclude, injection of botulinum-A 
      toxin into bulbospongiosus seems to be safe but failed to prove clinical efficacy 
      for treatment of lifelong premature ejaculation when compared to placebo.
CI  - (c) 2024. The Author(s).
FAU - Almekaty, Khaled
AU  - Almekaty K
AUID- ORCID: 0000-0002-9815-7035
AD  - Urology Department, Tanta University, Tanta, Egypt. dr.khaledhafez@yahoo.com.
FAU - Ghaith, Ahmed
AU  - Ghaith A
AUID- ORCID: 0000-0002-9102-1821
AD  - Urology Department, Tanta University, Tanta, Egypt.
FAU - Ragab, Maged
AU  - Ragab M
AD  - Urology Department, Tanta University, Tanta, Egypt.
FAU - Rashed, Ayman
AU  - Rashed A
AD  - Urology Department, 6th of October University, Cairo, Egypt.
FAU - Hagras, Ayman
AU  - Hagras A
AD  - Urology Department, Tanta University, Tanta, Egypt.
FAU - Ghoneem, Ayman
AU  - Ghoneem A
AD  - Urology Department, Tanta University, Tanta, Egypt.
FAU - Raheem, Amr Abdel
AU  - Raheem AA
AUID- ORCID: 0000-0002-5505-9291
AD  - Andrology Department, Cairo University, Cairo, Egypt.
FAU - Zahran, Mohamed H
AU  - Zahran MH
AD  - Mansoura Urology and Nephrology Centre, Mansoura, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20240202
PL  - England
TA  - Int J Impot Res
JT  - International journal of impotence research
JID - 9007383
SB  - IM
EDAT- 2024/02/03 00:42
MHDA- 2024/02/03 00:42
CRDT- 2024/02/02 23:47
PHST- 2023/06/30 00:00 [received]
PHST- 2024/01/17 00:00 [accepted]
PHST- 2024/01/03 00:00 [revised]
PHST- 2024/02/03 00:42 [medline]
PHST- 2024/02/03 00:42 [pubmed]
PHST- 2024/02/02 23:47 [entrez]
AID - 10.1038/s41443-024-00831-8 [pii]
AID - 10.1038/s41443-024-00831-8 [doi]
PST - aheadofprint
SO  - Int J Impot Res. 2024 Feb 2. doi: 10.1038/s41443-024-00831-8.