PMID- 38308203
OWN - NLM
STAT- MEDLINE
DCOM- 20240212
LR  - 20240212
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 24
IP  - 1
DP  - 2024 Feb 2
TI  - Study on the correlation between iris blood flow, iris thickness and pupil 
      diameter in the resting state and after pharmacological mydriasis in patients 
      with diabetes mellitus.
PG  - 52
LID - 10.1186/s12886-024-03322-y [doi]
LID - 52
AB  - BACKGROUND: To investigate whether iris blood flow and iris thickness at the iris 
      smooth muscle region affect the pupil diameter at rest and after drug-induced 
      mydriasis in patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes 
      mellitus (T2DM). METHODS: T1DM patients and healthy children were recruited from 
      the SCADE cohort. T2DM patients and healthy adults were recruited from patients 
      undergoing cataract surgery at Shanghai General Hospital. Iris vessel density, 
      pupil diameter (PD) and iris thickness were measured in both the resting and 
      drug-induced mydriasis states. Iris vessel density was measured by optical 
      coherence tomography angiography (OCTA), PD was measured by a pupilometer, and 
      iris thickness at the iris smooth muscle regions were measured using anterior 
      segment optical coherence tomography (AS-OCT). RESULTS: The study included 34 
      pediatric T1DM patients and 50 adult T2DM patients, both groups without diabetic 
      retinopathy, and age-sex-matched healthy controls. At baseline, T1DM children and 
      healthy children showed no differences in iris blood flow, iris thickness, or PD. 
      However, the adult T2DM group exhibited higher vessel density at the pupil 
      margin, thinner iris thickness at the iris dilator region, and smaller PD 
      compared to healthy adults, with these differences being statistically 
      significant (P < 0.05). After pupil dilation, there were no changes in iris blood 
      flow and PD in the T1DM group compared to healthy children, whereas the T2DM 
      group showed a significantly smaller PD compared to healthy adults. Multivariate 
      regression analysis revealed that in the T2DM group, glycated hemoglobin was an 
      independent factor of PD after dilation (beta=-0.490, p = 0.031), with no such 
      factors identified in the T1DM group. CONCLUSION: The insufficiently dilated 
      pupil diameter after drug-induced mydriasis is correlated to the level of 
      glycated hemoglobin among T2DM patients. TRIAL REGISTRATION: The registration 
      number on the clinical trial website was NCT03631108.
CI  - (c) 2024. The Author(s).
FAU - Cui, Lipu
AU  - Cui L
AD  - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong 
      University School of medicine, Shanghai, China.
FAU - Xiao, Ying
AU  - Xiao Y
AD  - Department of Ophthalmology, Children's Hospital of Fudan University, No. 399 
      Wanyuan Road, 201102, Shanghai, China.
FAU - Xiang, Zhaoyu
AU  - Xiang Z
AD  - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong 
      University School of medicine, Shanghai, China.
FAU - Chen, Zhangling
AU  - Chen Z
AD  - Department of Ophthalmology, Shanghai Songjiang District Central Hospital, 
      Shanghai, China.
FAU - Yang, Chenhao
AU  - Yang C
AD  - Department of Ophthalmology, Children's Hospital of Fudan University, No. 399 
      Wanyuan Road, 201102, Shanghai, China. ychben@hotmail.com.
FAU - Zou, Haidong
AU  - Zou H
AD  - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong 
      University School of medicine, Shanghai, China. zouhaidong@sjtu.edu.cn.
AD  - Shanghai Eye Diseases Prevention & Treatment Center, Shanghai Eye Hospital, 
      Shanghai, China. zouhaidong@sjtu.edu.cn.
AD  - Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. 
      zouhaidong@sjtu.edu.cn.
AD  - National Clinical Research Center for Eye Diseases, Shanghai, China. 
      zouhaidong@sjtu.edu.cn.
AD  - Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, 
      Shanghai, China. zouhaidong@sjtu.edu.cn.
LA  - eng
SI  - ClinicalTrials.gov/NCT03631108
GR  - 2021YFC2702100/Chinese National key research and development program/
GR  - 19DZ2250100/Shanghai engineering research center of precise diagnosis and 
      treatment of eye diseases, Shanghai, China/
PT  - Clinical Trial
PT  - Journal Article
DEP - 20240202
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
RN  - 0 (Glycated Hemoglobin)
SB  - IM
MH  - Adult
MH  - Child
MH  - Humans
MH  - China
MH  - *Diabetes Mellitus, Type 1/complications
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Dilatation, Pathologic
MH  - Glycated Hemoglobin
MH  - Intraocular Pressure
MH  - Iris
MH  - *Mydriasis/chemically induced
MH  - Pupil/physiology
MH  - Tomography, Optical Coherence
MH  - Male
MH  - Female
PMC - PMC10835944
OTO - NOTNLM
OT  - Pupil abnormalities
OT  - Type 1 diabetes
OT  - Type 2 diabetes
OT  - iris blood flow
OT  - iris thickness
COIS- The authors declare no competing interests.
EDAT- 2024/02/03 00:41
MHDA- 2024/02/05 06:44
PMCR- 2024/02/02
CRDT- 2024/02/02 23:53
PHST- 2023/09/08 00:00 [received]
PHST- 2024/01/23 00:00 [accepted]
PHST- 2024/02/05 06:44 [medline]
PHST- 2024/02/03 00:41 [pubmed]
PHST- 2024/02/02 23:53 [entrez]
PHST- 2024/02/02 00:00 [pmc-release]
AID - 10.1186/s12886-024-03322-y [pii]
AID - 3322 [pii]
AID - 10.1186/s12886-024-03322-y [doi]
PST - epublish
SO  - BMC Ophthalmol. 2024 Feb 2;24(1):52. doi: 10.1186/s12886-024-03322-y.