PMID- 38308476
OWN - NLM
STAT- MEDLINE
DCOM- 20240223
LR  - 20240223
IS  - 1557-8577 (Electronic)
IS  - 1549-1684 (Linking)
VI  - 27
IP  - 1
DP  - 2024 Feb
TI  - The Clinical Effects of Pharmacotherapy Combined with Blood Flow Restriction and 
      Isometric Exercise Training in Rehabilitating Patients with Heart Failure with 
      Reduced Ejection Fraction.
PG  - 33-40
LID - 10.1089/rej.2023.0070 [doi]
AB  - Heart failure with reduced ejection fraction (HFrEF) is associated with reduced 
      cardiac function and impaired quality of life. Blood flow restriction (BFR) 
      training is emerging as a potential adjunctive therapy. This study aimed at 
      evaluating the efficacy of combination of BFR and isometric exercises on cardiac 
      function, functional status, and quality of life in HFrEF patients. Totally 44 
      patients with HFrEF were equally divided into a control group and a combined 
      treatment group. Both groups received standard pharmacotherapy and upper limb 
      exercise, with the combined group also undergoing BFR and isometric exercise 
      training. We assessed demographic and clinical characteristics, New York Heart 
      Association (NYHA) functional classification, cardiac function parameters, serum 
      Brain Natriuretic Peptide levels, physical capacity via the 6-minute walking 
      test, and quality of life using the Heart Failure Questionnaire (Minnesota Living 
      with Heart Failure Questionnaire). Post-treatment, the combined group 
      significantly improved in NYHA classification (p = 0.012), with more patients 
      shifting to a better class. Cardiac function improved in both groups, with the 
      combined group showing a greater increase in mean left ventricular ejection 
      fractions (p < 0.001), and reductions in left ventricular end-diastolic and 
      end-systolic diameters (p < 0.05). The addition of BFR training to standard 
      pharmacotherapy with upper limb exercise in HFrEF patients led to significant 
      enhancements in cardiac function, functional status, and quality of life. These 
      findings support the integration of BFR training into conventional HFrEF 
      treatment regimens to maximize patient recovery outcomes.
FAU - Wu, Pinxia
AU  - Wu P
AD  - Department of Rehabilitation Medicine and Chuzhou First People's Hospital, 
      Chuzhou, Anhui, China.
FAU - Liu, Yu
AU  - Liu Y
AD  - Department of Cardiovascular Division, Chuzhou First People's Hospital, Chuzhou, 
      Anhui, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Rejuvenation Res
JT  - Rejuvenation research
JID - 101213381
SB  - IM
MH  - Humans
MH  - *Heart Failure/drug therapy
MH  - Stroke Volume/physiology
MH  - Quality of Life
MH  - Exercise/physiology
MH  - Ventricular Function, Left/physiology
OTO - NOTNLM
OT  - blood flow restriction (BFR) Training
OT  - cardiac function
OT  - heart failure with reduced ejection fraction (HFrEF)
OT  - isometric exercise
EDAT- 2024/02/03 10:42
MHDA- 2024/02/23 06:44
CRDT- 2024/02/03 03:09
PHST- 2024/02/23 06:44 [medline]
PHST- 2024/02/03 10:42 [pubmed]
PHST- 2024/02/03 03:09 [entrez]
AID - 10.1089/rej.2023.0070 [doi]
PST - ppublish
SO  - Rejuvenation Res. 2024 Feb;27(1):33-40. doi: 10.1089/rej.2023.0070.