PMID- 3830930
OWN - NLM
STAT- MEDLINE
DCOM- 19860428
LR  - 20140603
VI  - 9
IP  - 6
DP  - 1985
TI  - L-tryptophan does not increase weight loss in carbohydrate-craving obese 
      subjects.
PG  - 375-80
AB  - Eight subjects, aged 26 to 50 years, who had long histories of carbohydrate (CHO) 
      craving and were more than 45 kg above desirable body weight participated in a 
      randomized, double-blind, crossover pilot study on the effects of L-tryptophan on 
      weight loss and mood state. One g of tryptophan with 10 g of CHO was administered 
      three times a day, 30 min before meals, as an adjunct to a weight-loss protocol 
      that included nutritional consultation teaching low fat, high fiber diets ranging 
      from 1200-1600 kcals/day, behavior modification, and supportive therapy. During 
      the pretreatment period, body weight and plasma tryptophan levels were measured 
      and the Beck Depression Inventory, SCL 90 rating, and Profile-of-Mood State 
      (POMS) were used to assess mood. During the treatment periods, subjects kept 
      daily records of food intake and the timing of medication. All patients were seen 
      at least biweekly. After six weeks on medication, baseline measurements were 
      repeated and the crossover between tryptophan and placebo was implemented. After 
      an additional six weeks on placebo or tryptophan, the same measurements were 
      repeated. For the eight patients who completed the three-month protocol, the mean 
      weight loss for six weeks on placebo was 1.14 kg and for six weeks on tryptophan 
      was 2.3 kg. Mean Beck scores were 8.8 during the control period, 8.3 on placebo, 
      and 10.9 on tryptophan. Mean SCL 90 ratings were 69.2 during the control, 54.6 on 
      placebo, and 64.2 on tryptophan. Mean scores for total mood disturbance on the 
      POMS were 48 during the control period, 43 on placebo, and 52 on 
      tryptophan.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Strain, G W
AU  - Strain GW
FAU - Strain, J J
AU  - Strain JJ
FAU - Zumoff, B
AU  - Zumoff B
LA  - eng
GR  - CA-22795/CA/NCI NIH HHS/United States
GR  - R01-AM30978/AM/NIADDK NIH HHS/United States
GR  - RR-53/RR/NCRR NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Int J Obes
JT  - International journal of obesity
JID - 7703240
RN  - 333DO1RDJY (Serotonin)
RN  - 8DUH1N11BX (Tryptophan)
SB  - IM
MH  - Adult
MH  - Appetite/drug effects
MH  - Body Weight/*drug effects
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/*drug therapy
MH  - Pilot Projects
MH  - Serotonin/biosynthesis
MH  - Tryptophan/*administration & dosage
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
PST - ppublish
SO  - Int J Obes. 1985;9(6):375-80.