PMID- 38309699
OWN - NLM
STAT- MEDLINE
DCOM- 20240205
LR  - 20240206
IS  - 1210-7778 (Print)
IS  - 1210-7778 (Linking)
VI  - 31
IP  - 4
DP  - 2023 Dec
TI  - Association among serum per- and polyfluoroalkyl substances, lipid profile and 
      metabolic syndrome in Czech adults, HBM-EHES survey 2019.
PG  - 227-234
LID - 10.21101/cejph.a7799 [doi]
AB  - OBJECTIVES: Per- and polyfluoroalkyl substances (PFASs) are a large group of 
      persistent synthetic chemicals widely used commercially. They accumulate 
      increasingly in all environmental components and enter the organisms, including 
      humans. Some of them are associated with the risk of harm to health, among others 
      with metabolic disorders. To test the associations between blood serum levels of 
      PFASs and blood lipid profile as well as metabolic syndrome, we linked human 
      biomonitoring with the Czech Health Examination Survey (CZ-EHES) conducted in 
      2019. METHODS: A total of 168 participants of the CZ-EHES survey aged 25-64 years 
      were examined including anthropometrical data and analyses for serum PFAS and 
      blood lipid levels. Extended model approach in multiple linear regression models 
      was used for identification of the associations between serum levels of 11 PFASs 
      and lipid profile components. The relation between PFAS serum levels and 
      metabolic syndrome prevalence was tested using a logistic regression model. 
      RESULTS: Six PFASs were detected over the limit of quantification in at least 40% 
      cases and were examined in subsequent analyses: perfluorodecanoic acid (PFDA), 
      perfluorohexane sulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), 
      perfluorononanoic acid (PFNA), perfluorooctane sulfonic acid (PFOS), 
      perfluoroundecanoic acid (PFUdA). The most dominant was PFOS with the mean value 
      amounting to 4.81 ng/ml. After adjusting for potential confounders, we found a 
      significant positive association between serum PFHxS and blood total cholesterol 
      (p = 0.005) as well as LDL-cholesterol (p = 0.008). Significant positive 
      association was also found between PFDA and HDL-cholesterol levels (p = 0.010). 
      No significant associations were detected between PFASs and triglycerides, and 
      between PFASs and metabolic syndrome. CONCLUSIONS: We found some evidence of a 
      significant association between blood serum PFAS levels and blood cholesterol 
      levels. Our results did not confirm an association between serum PFASs and the 
      metabolic syndrome prevalence.
FAU - Puklova, Vladimira
AU  - Puklova V
AD  - National Institute of Public Health, Prague, Czech Republic.
FAU - Capkova, Nadezda
AU  - Capkova N
AD  - National Institute of Public Health, Prague, Czech Republic.
FAU - Fialova, Alena
AU  - Fialova A
AD  - National Institute of Public Health, Prague, Czech Republic.
AD  - Third Faculty of Medicine, Charles University in Prague, Czech Republic.
FAU - Vavrous, Adam
AU  - Vavrous A
AD  - National Institute of Public Health, Prague, Czech Republic.
FAU - Zejglicova, Kristyna
AU  - Zejglicova K
AD  - National Institute of Public Health, Prague, Czech Republic.
FAU - Cerna, Milena
AU  - Cerna M
AD  - National Institute of Public Health, Prague, Czech Republic.
AD  - Third Faculty of Medicine, Charles University in Prague, Czech Republic.
LA  - eng
PT  - Journal Article
PL  - Czech Republic
TA  - Cent Eur J Public Health
JT  - Central European journal of public health
JID - 9417324
RN  - 0 (Environmental Pollutants)
RN  - 0 (Lipids)
RN  - 0 (Fluorocarbons)
RN  - 335-76-2 (perfluorodecanoic acid)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
RN  - 355-46-4 (perfluorohexanesulfonic acid)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - 0 (Decanoic Acids)
RN  - 0 (Sulfonic Acids)
RN  - 0 (Alkanesulfonic Acids)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Environmental Pollutants
MH  - *Metabolic Syndrome/epidemiology
MH  - Serum
MH  - Czech Republic/epidemiology
MH  - Lipids
MH  - *Fluorocarbons
MH  - Cholesterol
MH  - *Decanoic Acids
MH  - *Sulfonic Acids
MH  - *Alkanesulfonic Acids
OTO - NOTNLM
OT  - human biomonitoring
OT  - lipid profile
OT  - metabolic syndrome
OT  - serum PFASs
EDAT- 2024/02/04 00:42
MHDA- 2024/02/05 06:42
CRDT- 2024/02/03 19:36
PHST- 2023/03/20 00:00 [received]
PHST- 2023/12/06 00:00 [accepted]
PHST- 2024/02/05 06:42 [medline]
PHST- 2024/02/04 00:42 [pubmed]
PHST- 2024/02/03 19:36 [entrez]
AID - 10.21101/cejph.a7799 [doi]
PST - ppublish
SO  - Cent Eur J Public Health. 2023 Dec;31(4):227-234. doi: 10.21101/cejph.a7799.