PMID- 38309986
OWN - NLM
STAT- MEDLINE
DCOM- 20240415
LR  - 20240416
IS  - 1878-0210 (Electronic)
IS  - 1878-0210 (Linking)
VI  - 18
IP  - 2
DP  - 2024 Apr
TI  - HbA1c and systolic blood pressure variation to predict all-cause mortality in 
      patients with type 2 diabetes mellitus.
PG  - 146-150
LID - S1751-9918(24)00026-3 [pii]
LID - 10.1016/j.pcd.2024.01.014 [doi]
AB  - BACKGROUND: Glycated hemoglobin A1c (HbA1c) variation or blood pressure (BP) 
      variation was known to be an independent predictor of all-cause mortality in 
      patients with type 2 diabetes mellitus (T2DM). This study aimed to investigate 
      the combined effect of HbA1c and systolic blood pressure (SBP) variation on 
      all-cause mortality and if there was a gender difference in patients with T2DM. 
      METHODS: Patients with T2DM who had at least three HbA1c, SBP measurements within 
      12-24 months during 2001-2007 were included. Coefficient of variation (CV) was 
      used to evaluate variation. The 75th percentile of HbA1c-CV and SBP-CV were set 
      as a cutoff to define high and low variation. Hazard ratios (HRs) and 95% 
      confidence intervals were estimated using Cox proportional hazard models. 
      RESULTS: A total of 2744 patients were included, of whom 769 died during the 11.7 
      observation years. The associated risk of all-cause mortality was 1.22 [1.01- 
      1.48], P = 0.044, for low HbA1c-CV & high SBP-CV; 1.28 [1.04-1.57], P = 0.020, 
      for high HbA1c-CV & low SBP-CV; and 1.68 [1.31-2.17], P < 0.001, for high 
      HbA1c-CV & high SBP-CV. The associated risk remained unchanged in either males or 
      females older than 50 years old, although there is only numerically higher for 
      high HbA1c-CV & low SBP-CV in females older than 50 years old. CONCLUSIONS: Both 
      HbA1c and SBP variation were significant predictors of all-cause mortality in 
      patients with T2DM. The combined effect was higher than either alone and no 
      gender difference in patients older than 50 years old.
CI  - Copyright (c) 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Lee, Yun-Chi
AU  - Lee YC
AD  - Division of Endocrinology and Metabolism, Department of Medicine, China Medical 
      University Hospital, Taichung 40447, Taiwan; Department of Medicine, China 
      Medical University, Taichung 40402, Taiwan.
FAU - Chang, Chwen-Tzuei
AU  - Chang CT
AD  - Division of Endocrinology and Metabolism, Department of Medicine, China Medical 
      University Hospital, Taichung 40447, Taiwan.
FAU - Chen, Rong-Hsing
AU  - Chen RH
AD  - Division of Endocrinology and Metabolism, Department of Medicine, China Medical 
      University Hospital, Taichung 40447, Taiwan.
FAU - Wang, Tzu-Yuan
AU  - Wang TY
AD  - Division of Endocrinology and Metabolism, Department of Medicine, China Medical 
      University Hospital, Taichung 40447, Taiwan; School of Medicine, China Medical 
      University, Taichung 40402, Taiwan.
FAU - Chen, Ching-Chu
AU  - Chen CC
AD  - Division of Endocrinology and Metabolism, Department of Medicine, China Medical 
      University Hospital, Taichung 40447, Taiwan; School of Chinese Medicine, China 
      Medical University, Taichung 40402, Taiwan. Electronic address: 
      chingchu@ms15.hinet.net.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20240202
PL  - England
TA  - Prim Care Diabetes
JT  - Primary care diabetes
JID - 101463825
RN  - 0 (Glycated Hemoglobin)
SB  - IM
MH  - Male
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Diabetes Mellitus, Type 2
MH  - Glycated Hemoglobin
MH  - Blood Pressure/physiology
MH  - Proportional Hazards Models
MH  - Risk Factors
OTO - NOTNLM
OT  - Diabetes
OT  - HbA1c
OT  - Mortality
OT  - Systolic blood pressure
OT  - Variation
COIS- Declaration of Competing Interest The authors declare no conflict of interest.
EDAT- 2024/02/04 00:42
MHDA- 2024/04/15 06:44
CRDT- 2024/02/03 21:59
PHST- 2023/11/30 00:00 [received]
PHST- 2024/01/20 00:00 [revised]
PHST- 2024/01/28 00:00 [accepted]
PHST- 2024/04/15 06:44 [medline]
PHST- 2024/02/04 00:42 [pubmed]
PHST- 2024/02/03 21:59 [entrez]
AID - S1751-9918(24)00026-3 [pii]
AID - 10.1016/j.pcd.2024.01.014 [doi]
PST - ppublish
SO  - Prim Care Diabetes. 2024 Apr;18(2):146-150. doi: 10.1016/j.pcd.2024.01.014. Epub 
      2024 Feb 2.