PMID- 38310873
OWN - NLM
STAT- Publisher
LR  - 20240204
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Linking)
DP  - 2024 Feb 2
TI  - Insulin Resistance, Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes 
      Mellitus: Clinical and Experimental Perspective.
LID - 10.4093/dmj.2023.0350 [doi]
AB  - It has been generally accepted that insulin resistance (IR) and reduced insulin 
      secretory capacity are the basic pathogenesis of type 2 diabetes mellitus (T2DM). 
      In addition to genetic factors, the persistence of systemic inflammation caused 
      by obesity and the associated threat of lipotoxicity increase the risk of T2DM. 
      In particular, the main cause of IR is obesity and subjects with T2DM have a 
      higher body mass index (BMI) than normal subjects according to recent studies. 
      The prevalence of T2DM with IR has increased with increasing BMI during the past 
      three decades. According to recent studies, homeostatic model assessment of IR 
      was increased compared to that of the 1990s. Rising prevalence of obesity in 
      Korea have contributed to the development of IR, non-alcoholic fatty liver 
      disease and T2DM and cutting this vicious cycle is important. My colleagues and I 
      have investigated this pathogenic mechanism on this theme through clinical and 
      experimental studies over 20 years and herein, I would like to summarize some of 
      our studies with deep gratitude for receiving the prestigious 2023 Sulwon Award.
FAU - Jung, Inha
AU  - Jung I
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea 
      University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.
FAU - Koo, Dae-Jeong
AU  - Koo DJ
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Changwon Fatima Hospital, Changwon, Korea.
FAU - Lee, Won-Young
AU  - Lee WY
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20240202
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
SB  - IM
OTO - NOTNLM
OT  - Diabetes mellitus, type 2
OT  - Insulin resistance
OT  - Non-alcoholic fatty liver disease
OT  - Obesity
EDAT- 2024/02/05 00:42
MHDA- 2024/02/05 00:42
CRDT- 2024/02/04 18:46
PHST- 2023/10/04 00:00 [received]
PHST- 2024/12/26 00:00 [accepted]
PHST- 2024/02/05 00:42 [medline]
PHST- 2024/02/05 00:42 [pubmed]
PHST- 2024/02/04 18:46 [entrez]
AID - dmj.2023.0350 [pii]
AID - 10.4093/dmj.2023.0350 [doi]
PST - aheadofprint
SO  - Diabetes Metab J. 2024 Feb 2. doi: 10.4093/dmj.2023.0350.