PMID- 38312116 OWN - NLM STAT- MEDLINE DCOM- 20240206 LR - 20240206 IS - 2219-2840 (Electronic) IS - 1007-9327 (Print) IS - 1007-9327 (Linking) VI - 30 IP - 2 DP - 2024 Jan 14 TI - Long-term prognosis and its associated predictive factors in patients with eosinophilic gastroenteritis. PG - 146-157 LID - 10.3748/wjg.v30.i2.146 [doi] AB - BACKGROUND: Eosinophilic gastroenteritis (EGE) is a chronic recurrent disease with abnormal eosinophilic infiltration in the gastrointestinal tract. Glucocorticoids remain the most common treatment method. However, disease relapse and glucocorticoid dependence remain notable problems. To date, few studies have illuminated the prognosis of EGE and risk factors for disease relapse. AIM: To describe the clinical characteristics of EGE and possible predictive factors for disease relapse based on long-term follow-up. METHODS: This was a retrospective cohort study of 55 patients diagnosed with EGE admitted to one medical center between 2013 and 2022. Clinical records were collected and analyzed. Kaplan-Meier curves and log-rank tests were conducted to reveal the risk factors for long-term relapse-free survival (RFS). RESULTS: EGE showed a median onset age of 38 years and a slight female predominance (56.4%). The main clinical symptoms were abdominal pain (89.1%), diarrhea (61.8%), nausea (52.7%), distension (49.1%) and vomiting (47.3%). Forty-three (78.2%) patients received glucocorticoid treatment, and compared with patients without glucocorticoid treatments, they were more likely to have elevated serum immunoglobin E (IgE) (86.8% vs 50.0%, P = 0.022) and descending duodenal involvement (62.8% vs 27.3%, P = 0.046) at diagnosis. With a median follow-up of 67 mo, all patients survived, and 56.4% had at least one relapse. Six variables at baseline might have been associated with the overall RFS rate, including age at diagnosis < 40 years [hazard ratio (HR) 2.0408, 95% confidence interval (CI): 1.0082-4.1312, P = 0.044], body mass index (BMI) > 24 kg/m(2) (HR 0.3922, 95%CI: 0.1916-0.8027, P = 0.014), disease duration from symptom onset to diagnosis > 3.5 mo (HR 2.4725, 95%CI: 1.220-5.0110, P = 0.011), vomiting (HR 3.1259, 95%CI: 1.5246-6.4093, P = 0.001), total serum IgE > 300 KU/L at diagnosis (HR 0.2773, 95%CI: 0.1204-0.6384, P = 0.022) and glucocorticoid treatment (HR 6.1434, 95%CI: 2.8446-13.2676, P = 0.003). CONCLUSION: In patients with EGE, younger onset age, longer disease course, vomiting and glucocorticoid treatment were risk factors for disease relapse, whereas higher BMI and total IgE level at baseline were protective. CI - (c)The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. FAU - Li, Kai-Wen AU - Li KW AD - Department of Gastroenterology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730, China. FAU - Ruan, Ge-Chong AU - Ruan GC AD - Department of Gastroenterology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730, China. FAU - Liu, Shuang AU - Liu S AD - Department of Allergy, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730, China. FAU - Xu, Tian-Ming AU - Xu TM AD - Department of Gastroenterology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730, China. FAU - Ma, Ye AU - Ma Y AD - Department of Gastroenterology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730, China. FAU - Zhou, Wei-Xun AU - Zhou WX AD - Department of Pathology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730, China. FAU - Liu, Wei AU - Liu W AD - Department of Radiology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730, China. FAU - Zhao, Peng-Yu AU - Zhao PY AD - Affairs Office, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital (West campus), Beijing 100032, China. FAU - Du, Zhi-Rong AU - Du ZR AD - Department of Allergy, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730, China. FAU - Li, Ji AU - Li J AD - Department of Gastroenterology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730, China. liji0235@pumch.cn. FAU - Li, Jing-Nan AU - Li JN AD - Department of Gastroenterology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730, China. LA - eng PT - Journal Article PL - United States TA - World J Gastroenterol JT - World journal of gastroenterology JID - 100883448 RN - 0 (Glucocorticoids) RN - 37341-29-0 (Immunoglobulin E) RN - Eosinophilic enteropathy SB - IM MH - Humans MH - Female MH - Adult MH - Male MH - *Glucocorticoids/therapeutic use MH - Retrospective Studies MH - *Enteritis/diagnosis/complications MH - Prognosis MH - Chronic Disease MH - Vomiting MH - Recurrence MH - Immunoglobulin E MH - *Eosinophilia MH - *Gastritis PMC - PMC10835522 OTO - NOTNLM OT - Eosinophilic gastroenteritis OT - Glucocorticoid OT - Glucocorticoid dependence OT - Prognosis OT - Relapse COIS- Conflict-of-interest statement: All the Authors have no conflict of interest related to the manuscript. EDAT- 2024/02/05 06:42 MHDA- 2024/02/06 06:43 PMCR- 2024/01/14 CRDT- 2024/02/05 04:14 PHST- 2023/08/22 00:00 [received] PHST- 2023/11/28 00:00 [revised] PHST- 2023/12/25 00:00 [accepted] PHST- 2024/02/06 06:43 [medline] PHST- 2024/02/05 06:42 [pubmed] PHST- 2024/02/05 04:14 [entrez] PHST- 2024/01/14 00:00 [pmc-release] AID - 10.3748/wjg.v30.i2.146 [doi] PST - ppublish SO - World J Gastroenterol. 2024 Jan 14;30(2):146-157. doi: 10.3748/wjg.v30.i2.146.