PMID- 38313078
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240210
IS  - 2752-4191 (Electronic)
IS  - 2752-4191 (Linking)
VI  - 4
IP  - 1
DP  - 2024 Jan
TI  - The impact of extracorporeal membrane oxygenation on mortality in patients with 
      cardiogenic shock post-acute myocardial infarction: a systematic review and 
      meta-analysis.
PG  - oeae003
LID - 10.1093/ehjopen/oeae003 [doi]
LID - oeae003
AB  - AIMS: Cardiogenic shock remains the leading cause of death in patients 
      hospitalized with acute myocardial infarction. Veno-arterial extracorporeal 
      membrane oxygenation (VA-ECMO) is increasingly used in the treatment of 
      infarct-related cardiogenic shock. However, there is limited evidence regarding 
      its beneficial impact on mortality. The aim of this study was to systematically 
      review studies reporting the impact of VA-ECMO on mortality in patients with 
      acute myocardial infarction complicated by cardiogenic shock. METHODS AND 
      RESULTS: A comprehensive search of medical databases (Cochrane Register and 
      PubMed) was conducted. Studies that reported mortality outcomes in patients 
      treated with VA-ECMO for infarct-related cardiogenic shock were included. The 
      database search yielded 1194 results, of which 11 studies were included in the 
      systematic review. Four of these studies, with a total of 586 patients, were 
      randomized controlled trials and were included in the meta-analysis. This 
      demonstrated that there was no significant difference in 30-day all-cause 
      mortality with the use of VA-ECMO compared with standard medical therapy [odds 
      ratio (OR) 0.91; 95% confidence interval (CI) 0.65-1.27]. Meta-analysis of two 
      studies showed that VA-ECMO was associated with a significant reduction in 
      12-month all-cause mortality (OR 0.31; 95% CI 0.11-0.86). Qualitative synthesis 
      of the observational studies showed that age, serum creatinine, serum lactate, 
      and successful revascularization are independent predictors of mortality. 
      CONCLUSION: Veno-arterial extracorporeal membrane oxygenation does not improve 
      30-day all-cause mortality in patients with cardiogenic shock following acute 
      myocardial infarction; however, there may be significant reduction in all-cause 
      mortality at 12 months. Further studies are needed to delineate the potential 
      benefit of VA-ECMO in long-term outcomes. REGISTRATION: The protocol was 
      registered in the PROSPERO International Prospective Register of Systematic 
      Reviews (ID: CRD42023461740).
CI  - (c) The Author(s) 2024. Published by Oxford University Press on behalf of the 
      European Society of Cardiology.
FAU - Paddock, Sophie
AU  - Paddock S
AUID- ORCID: 0000-0002-1163-9710
AD  - Cardiology Department, Norfolk and Norwich University Hospital, Colney Lane, 
      Norwich NR4 7UY, UK.
AD  - Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ, UK.
FAU - Meng, James
AU  - Meng J
AD  - Cardiology Department, Norfolk and Norwich University Hospital, Colney Lane, 
      Norwich NR4 7UY, UK.
AD  - Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ, UK.
FAU - Johnson, Nicholas
AU  - Johnson N
AD  - Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ, UK.
FAU - Chattopadhyay, Rahul
AU  - Chattopadhyay R
AD  - Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ, UK.
AD  - Cardiology Department, Cambridge University Hospital, Cambridge, UK.
FAU - Tsampasian, Vasiliki
AU  - Tsampasian V
AD  - Cardiology Department, Norfolk and Norwich University Hospital, Colney Lane, 
      Norwich NR4 7UY, UK.
AD  - Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ, UK.
FAU - Vassiliou, Vassilios
AU  - Vassiliou V
AUID- ORCID: 0000-0002-4005-7752
AD  - Cardiology Department, Norfolk and Norwich University Hospital, Colney Lane, 
      Norwich NR4 7UY, UK.
AD  - Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ, UK.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20240118
PL  - England
TA  - Eur Heart J Open
JT  - European heart journal open
JID - 9918282081406676
PMC - PMC10836884
OTO - NOTNLM
OT  - Acute myocardial infarction
OT  - Cardiogenic shock
OT  - Extracorporeal membrane oxygenation
COIS- Conflict of interest: There are no conflicts of interest related to this work.
EDAT- 2024/02/05 06:44
MHDA- 2024/02/05 06:45
PMCR- 2024/01/18
CRDT- 2024/02/05 04:31
PHST- 2023/10/27 00:00 [received]
PHST- 2023/11/29 00:00 [revised]
PHST- 2024/01/14 00:00 [accepted]
PHST- 2024/02/05 06:45 [medline]
PHST- 2024/02/05 06:44 [pubmed]
PHST- 2024/02/05 04:31 [entrez]
PHST- 2024/01/18 00:00 [pmc-release]
AID - oeae003 [pii]
AID - 10.1093/ehjopen/oeae003 [doi]
PST - epublish
SO  - Eur Heart J Open. 2024 Jan 18;4(1):oeae003. doi: 10.1093/ehjopen/oeae003. 
      eCollection 2024 Jan.