PMID- 38313271
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240212
DP  - 2024 Jan 16
TI  - Clinical Use of Bedside Portable Low-field Brain Magnetic Resonance Imaging in 
      Patients on ECMO: The Results from Multicenter SAFE MRI ECMO Study.
LID - rs.3.rs-3858221 [pii]
LID - 10.21203/rs.3.rs-3858221/v1 [doi]
AB  - PURPOSE: Early detection of acute brain injury (ABI) is critical for improving 
      survival for patients with extracorporeal membrane oxygenation (ECMO) support. We 
      aimed to evaluate the safety of ultra-low-field portable MRI (ULF-pMRI) and the 
      frequency and types of ABI observed during ECMO support. METHODS: We conducted a 
      multicenter prospective observational study (NCT05469139) at two academic 
      tertiary centers (August 2022-November 2023). Primary outcomes were safety and 
      validation of ULF-pMRI in ECMO, defined as exam completion without adverse events 
      (AEs); secondary outcomes were ABI frequency and type. RESULTS: ULF-pMRI was 
      performed in 50 patients with 34 (68%) on venoarterial (VA)-ECMO (11 central; 23 
      peripheral) and 16 (32%) with venovenous (VV)-ECMO (9 single lumen; 7 double 
      lumen). All patients were imaged successfully with ULF-pMRI, demonstrating 
      discernible intracranial pathologies with good quality. AEs occurred in 3 (6%) 
      patients (2 minor; 1 serious) without causing significant clinical issues.ABI was 
      observed in ULF-pMRI scans for 22 patients (44%): ischemic stroke (36%), 
      intracranial hemorrhage (6%), and hypoxic-ischemic brain injury (4%). Of 18 
      patients with both ULF-pMRI and head CT (HCT) within 24 hours, ABI was observed 
      in 9 patients with 10 events: 8 ischemic (8 observed on ULF-oMRI, 4 on HCT) and 2 
      hemorrhagic (1 observed on ULF-pMRI, 2 on HCT). CONCLUSIONS: ULF-pMRI was shown 
      to be safe and valid in ECMO patients across different ECMO cannulation 
      strategies. The incidence of ABI was high, and ULF-pMRI may more sensitive to 
      ischemic ABI than HCT. ULF-pMRI may benefit both clinical care and future studies 
      of ECMO-associated ABI.
FAU - Cho, Sung-Min
AU  - Cho SM
AUID- ORCID: 0000-0002-5132-0958
AD  - Johns Hopkins University School of Medicine.
FAU - Khanduja, Shivalika
AU  - Khanduja S
AD  - Johns Hopkins Hospital: Johns Hopkins Medicine.
FAU - Wilcox, Christopher
AU  - Wilcox C
AD  - Johns Hopkins Hospital: Johns Hopkins Medicine.
FAU - Dinh, Kha
AU  - Dinh K
AD  - UTHSC: The University of Texas Health Science Center at Houston.
FAU - Kim, Jiah
AU  - Kim J
AD  - Johns Hopkins Hospital: Johns Hopkins Medicine.
FAU - Kang, Jin Kook
AU  - Kang JK
AD  - Johns Hopkins Hospital: Johns Hopkins Medicine.
FAU - Chinedozi, Ifeanyi David
AU  - Chinedozi ID
AD  - Johns Hopkins Hospital: Johns Hopkins Medicine.
FAU - Darby, Zachary
AU  - Darby Z
AD  - Johns Hopkins Hospital: Johns Hopkins Medicine.
FAU - Acton, Matthew
AU  - Acton M
AD  - Johns Hopkins Hospital: Johns Hopkins Medicine.
FAU - Rando, Hannah
AU  - Rando H
AD  - Johns Hopkins Hospital: Johns Hopkins Medicine.
FAU - Briscoe, Jessica
AU  - Briscoe J
AD  - Johns Hopkins Hospital: Johns Hopkins Medicine.
FAU - Bush, Errol
AU  - Bush E
AD  - Johns Hopkins Hospital: Johns Hopkins Medicine.
FAU - Sair, Haris I
AU  - Sair HI
AD  - Johns Hopkins Hospital: Johns Hopkins Medicine.
FAU - Pitts, John
AU  - Pitts J
AD  - Hyperfine Inc.
FAU - Arlinghaus, Lori R
AU  - Arlinghaus LR
AD  - Hyperfine Inc.
FAU - Wandji, Audrey-Carelle N
AU  - Wandji AN
AD  - UTHSC: The University of Texas Health Science Center at Houston.
FAU - Moreno, Elena
AU  - Moreno E
AD  - UTHSC: The University of Texas Health Science Center at Houston.
FAU - Torres, Glenda
AU  - Torres G
AD  - UTHSC: The University of Texas Health Science Center at Houston.
FAU - Akkanti, Bindu
AU  - Akkanti B
AD  - UTHSC: The University of Texas Health Science Center at Houston.
FAU - Gavito-Higuera, Jose
AU  - Gavito-Higuera J
AD  - UTHSC: The University of Texas Health Science Center at Houston.
FAU - Keller, Steven
AU  - Keller S
AD  - Johns Hopkins Hospital: Johns Hopkins Medicine.
FAU - Choi, HuiMahn A
AU  - Choi HA
AD  - UTHSC: The University of Texas Health Science Center at Houston.
FAU - Kim, Bo Soo
AU  - Kim BS
AD  - Johns Hopkins Hospital: Johns Hopkins Medicine.
FAU - Gusdon, Aaron
AU  - Gusdon A
AD  - UTHSC: The University of Texas Health Science Center at Houston.
FAU - Whitman, Glenn Jr
AU  - Whitman GJ
AD  - Johns Hopkins Hospital: Johns Hopkins Medicine.
LA  - eng
GR  - K23 HL157610/HL/NHLBI NIH HHS/United States
GR  - K23 NS121628/NS/NINDS NIH HHS/United States
PT  - Preprint
DEP - 20240116
PL  - United States
TA  - Res Sq
JT  - Research square
JID - 101768035
PMC - PMC10836091
OTO - NOTNLM
OT  - ABI
OT  - ECMO
OT  - Portable MRI
OT  - acute brain injury
OT  - critical care
OT  - ultra-low-field MRI
COIS- Conflicts of Interest/Disclosures All other authors declare that the research was 
      conducted without any commercial or financial relationships that could be 
      construed as a potential conflict of interest.
EDAT- 2024/02/05 06:43
MHDA- 2024/02/05 06:44
PMCR- 2024/02/02
CRDT- 2024/02/05 04:37
PHST- 2024/02/05 06:43 [pubmed]
PHST- 2024/02/05 06:44 [medline]
PHST- 2024/02/05 04:37 [entrez]
PHST- 2024/02/02 00:00 [pmc-release]
AID - rs.3.rs-3858221 [pii]
AID - 10.21203/rs.3.rs-3858221/v1 [doi]
PST - epublish
SO  - Res Sq [Preprint]. 2024 Jan 16:rs.3.rs-3858221. doi: 10.21203/rs.3.rs-3858221/v1.