PMID- 38313852
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240206
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 15
IP  - 1
DP  - 2024 Jan 15
TI  - Heterogeneously elevated branched-chain/aromatic amino acids among new-onset 
      type-2 diabetes mellitus patients are potentially skewed diabetes predictors.
PG  - 53-71
LID - 10.4239/wjd.v15.i1.53 [doi]
AB  - BACKGROUND: The lack of specific predictors for type-2 diabetes mellitus (T2DM) 
      severely impacts early intervention/prevention efforts. Elevated branched-chain 
      amino acids (BCAAs: Isoleucine, leucine, valine) and aromatic amino acids (AAAs: 
      Tyrosine, tryptophan, phenylalanine)) show high sensitivity and specificity in 
      predicting diabetes in animals and predict T2DM 10-19 years before T2DM onset in 
      clinical studies. However, improvement is needed to support its clinical utility. 
      AIM: To evaluate the effects of body mass index (BMI) and sex on BCAAs/AAAs in 
      new-onset T2DM individuals with varying body weight. METHODS: Ninety-seven 
      new-onset T2DM patients (< 12 mo) differing in BMI [normal weight (NW), n = 33, 
      BMI = 22.23 +/- 1.60; overweight, n = 42, BMI = 25.9 +/- 1.07; obesity (OB), n = 22, 
      BMI = 31.23 +/- 2.31] from the First People's Hospital of Yunnan Province, Kunming, 
      China, were studied. One-way and 2-way ANOVAs were conducted to determine the 
      effects of BMI and sex on BCAAs/AAAs. RESULTS: Fasting serum AAAs, BCAAs, 
      glutamate, and alanine were greater and high-density lipoprotein (HDL) was lower 
      (P < 0.05, each) in OB-T2DM patients than in NW-T2DM patients, especially in male 
      OB-T2DM patients. Arginine, histidine, leucine, methionine, and lysine were 
      greater in male patients than in female patients. Moreover, histidine, alanine, 
      glutamate, lysine, valine, methionine, leucine, isoleucine, tyrosine, 
      phenylalanine, and tryptophan were significantly correlated with abdominal 
      adiposity, body weight and BMI, whereas isoleucine, leucine and phenylalanine 
      were negatively correlated with HDL. CONCLUSION: Heterogeneously elevated amino 
      acids, especially BCAAs/AAAs, across new-onset T2DM patients in differing BMI 
      categories revealed a potentially skewed prediction of T2DM development. The 
      higher BCAA/AAA levels in obese T2DM patients would support T2DM prediction in 
      obese individuals, whereas the lower levels of BCAAs/AAAs in NW-T2DM individuals 
      may underestimate T2DM risk in NW individuals. This potentially skewed T2DM 
      prediction should be considered when BCAAs/AAAs are to be used as the T2DM 
      predictor.
CI  - (c)The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Wang, Min
AU  - Wang M
AD  - School of Chemical Science and Technology, Yunnan University, Kunming 650091, 
      Yunnan Province, China.
FAU - Ou, Yang
AU  - Ou Y
AD  - Department of Endocrinology, The First People's Hospital of Yunnan Province, 
      Kunming 650032, Yunnan Province, China.
FAU - Yuan, Xiang-Lian
AU  - Yuan XL
AD  - Department of Endocrinology, The First People's Hospital of Yunnan Province, 
      Kunming 650032, Yunnan Province, China.
FAU - Zhu, Xiu-Fang
AU  - Zhu XF
AD  - School of Chemical Science and Technology, Yunnan University, Kunming 650091, 
      Yunnan Province, China.
FAU - Niu, Ben
AU  - Niu B
AD  - Department of Endocrinology, The First People's Hospital of Yunnan Province, 
      Kunming 650032, Yunnan Province, China.
FAU - Kang, Zhuang
AU  - Kang Z
AD  - Department of Endocrinology, The First People's Hospital of Yunnan Province, 
      Kunming 650032, Yunnan Province, China.
FAU - Zhang, Bing
AU  - Zhang B
AD  - Clinical Laboratory, Nanchong Central Hospital & The Second Clinical Medical 
      College of North Sichuan Medical University, Nanchong 637000, Sichuan Province, 
      China.
FAU - Ahmed, Anwar
AU  - Ahmed A
AD  - Department of Preventive Medicine and Biostatistics, Uniformed Services 
      University of the Health Sciences, Bethesda, MD 20814, United States.
FAU - Xing, Guo-Qiang
AU  - Xing GQ
AD  - The Affiliated Hospital and Second Clinical Medical College, North Sichuan 
      Medical University, Nanchong 637000, Sichuan Province, China.
AD  - Department of Research and Development, Lotus Biotech.com LLC, Gaithersburg, MD 
      20878, United States.
FAU - Su, Heng
AU  - Su H
AD  - Department of Endocrinology, The First People's Hospital of Yunnan Province, 
      Kunming 650032, Yunnan Province, China. su_hen@hotmail.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC10835491
OTO - NOTNLM
OT  - Branched-chain/aromatic amino acids
OT  - Hyperaminoacidemia
OT  - New-onset type-2 diabetes
OT  - Obesity
OT  - Predictor
OT  - Sex
COIS- Conflict-of-interest statement: All authors declare no potential conflicts of 
      interest.
EDAT- 2024/02/05 06:42
MHDA- 2024/02/05 06:43
PMCR- 2024/01/15
CRDT- 2024/02/05 04:52
PHST- 2023/09/13 00:00 [received]
PHST- 2023/11/03 00:00 [revised]
PHST- 2023/12/13 00:00 [accepted]
PHST- 2024/02/05 06:43 [medline]
PHST- 2024/02/05 06:42 [pubmed]
PHST- 2024/02/05 04:52 [entrez]
PHST- 2024/01/15 00:00 [pmc-release]
AID - 10.4239/wjd.v15.i1.53 [doi]
PST - ppublish
SO  - World J Diabetes. 2024 Jan 15;15(1):53-71. doi: 10.4239/wjd.v15.i1.53.