PMID- 3831409
OWN - NLM
STAT- MEDLINE
DCOM- 19860508
LR  - 20190824
IS  - 0021-4868 (Print)
IS  - 0021-4868 (Linking)
VI  - 26
IP  - 6
DP  - 1985 Nov
TI  - Prominent negative U wave in variant angina pectoris.
PG  - 885-96
AB  - The extremely prominent negative U wave occasionally appears during a cardiac 
      attack in variant angina pectoris. The clinical profile of the negative U wave 
      was therefore studied in 80 patients with variant angina pectoris (VA) and 33 
      controls with resting angina pectoris (RA). The prominent negative U wave 
      appeared in 55 of the patients with VA (68.8% of patients) and in 10 of the 
      patients with RA (30.3%); thus, there was a significant difference in the 
      appearance of the wave between the 2 groups of patients (p less than 0.001). The 
      leads in which the negative U wave appeared were mostly consistent with those in 
      which the ST segment was elevated. The negative U wave began to appear at about 
      the time when ST-segment elevation began to improve; the wave then gradually 
      became very prominent and then eventually disappeared. The patients with VA and 
      also those with RA on whose ECGs the negative U wave appeared during exercise 
      testing also had negative U waves during spontaneous episodes of angina. An 
      investigation of the frequency of appearance of ST deviation and negative U waves 
      during exercise testing, regardless of the type of angina pectoris, disclosed 
      that the negative U wave appeared in 14 of 20 patients with ST-segment elevation 
      (70% of patients), while the negative U wave appeared in only 52 of 519 patients 
      with either no ST change or ST-segment depression (10.4%); thus, there was a 
      significant difference in the appearance of the negative U wave between these 2 
      groups (p less than 0.001). Coronary cinearteriography failed to disclose any 
      apparent difference between the appearance of the negative U wave and the 
      presence of stenosis. The prognosis of VA and RA in patients with negative U 
      waves was less favorable compared to those without negative U waves. In 
      particular, we noted that of the 10 patients with RA associated with negative U 
      waves, 4 died. Although the mechanism of the negative U wave is not yet known, we 
      believe that the above findings contribute to its elucidation.
FAU - Kishida, H
AU  - Kishida H
FAU - Otsu, F
AU  - Otsu F
FAU - Suzuki, K
AU  - Suzuki K
FAU - Hata, N
AU  - Hata N
FAU - Kusama, Y
AU  - Kusama Y
FAU - Suzuki, T
AU  - Suzuki T
FAU - Nejima, J
AU  - Nejima J
FAU - Saito, T
AU  - Saito T
FAU - Iida, N
AU  - Iida N
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn Heart J
JT  - Japanese heart journal
JID - 0401175
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angina Pectoris, Variant/*physiopathology
MH  - Cineangiography
MH  - Coronary Angiography
MH  - *Electrocardiography
MH  - Exercise Test
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Rest
EDAT- 1985/11/01 00:00
MHDA- 1985/11/01 00:01
CRDT- 1985/11/01 00:00
PHST- 1985/11/01 00:00 [pubmed]
PHST- 1985/11/01 00:01 [medline]
PHST- 1985/11/01 00:00 [entrez]
AID - 10.1536/ihj.26.885 [doi]
PST - ppublish
SO  - Jpn Heart J. 1985 Nov;26(6):885-96. doi: 10.1536/ihj.26.885.