PMID- 38314224
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240206
IS  - 2067-0656 (Print)
IS  - 2069-4032 (Electronic)
VI  - 49
IP  - 3
DP  - 2023 Jul-Sep
TI  - PLGA-The Smart Biocompatible Polimer: Kinetic Degradation Studies and Active 
      Principle Release.
PG  - 416-422
LID - 10.12865/CHSJ.49.03.15 [doi]
AB  - The aim of our research was the development of prolonged delivery systems for 
      therapeutic agents with various properties (prevention and treatment of bone 
      diseases, anti-neoplastic, anti-inflammatory, antioxidant) that would ensure 
      sustained therapeutic levels of the active principle, above the minimum 
      inhibitory concentration, without reaching toxic levels over a long period of 
      time as alternatives to conventional routes of administration. PLGA (poly 
      lactic-co-glycolic acid), a biodegradable and biocompatible synthetic polymer, 
      FDA approved, with a 65:35 lactic acid (LA): glycolic acid (GA) copolymer ratio, 
      was chosen as delivery system. Our studies have shown that in PBS it undergoes 
      two simultaneous degradation processes, hydrolysis and autohydrolysis, degrading 
      completely in about 40 days. The release of the active principle is determined by 
      the diffusion from inside the polymer matrix to the outside, which occurs 
      simultaneously with the erosion of the polymer, during 35 days.
CI  - Copyright (c) 2023, Medical University Publishing House Craiova.
FAU - Ciocilteu, Maria-Viorica
AU  - Ciocilteu MV
AD  - University of Medicine and Pharmacy of Craiova, Petru Rares Street 2, 200349 
      Craiova, Romania.
FAU - Gabriela, Rau
AU  - Gabriela R
AD  - University of Medicine and Pharmacy of Craiova, Petru Rares Street 2, 200349 
      Craiova, Romania.
FAU - Amzoiu, Manuel Ovidiu
AU  - Amzoiu MO
AD  - University of Medicine and Pharmacy of Craiova, Petru Rares Street 2, 200349 
      Craiova, Romania.
FAU - Amzoiu, Denisa Constantina
AU  - Amzoiu DC
AD  - University of Medicine and Pharmacy of Craiova, Petru Rares Street 2, 200349 
      Craiova, Romania.
FAU - Pisoschi, Catalina Gabriela
AU  - Pisoschi CG
AD  - University of Medicine and Pharmacy of Craiova, Petru Rares Street 2, 200349 
      Craiova, Romania.
FAU - Poenariu, Beatrice Anne-Marie
AU  - Poenariu BA
AD  - University of Medicine and Pharmacy of Craiova, Petru Rares Street 2, 200349 
      Craiova, Romania.
LA  - eng
PT  - Journal Article
DEP - 20230930
PL  - Romania
TA  - Curr Health Sci J
JT  - Current health sciences journal
JID - 101597164
PMC - PMC10832882
OTO - NOTNLM
OT  - PLGA
OT  - biocompatible
OT  - kinetic studies
OT  - release
COIS- None to declare.
EDAT- 2024/02/05 06:43
MHDA- 2024/02/05 06:44
PMCR- 2023/07/01
CRDT- 2024/02/05 05:01
PHST- 2023/10/07 00:00 [received]
PHST- 2023/07/12 00:00 [accepted]
PHST- 2024/02/05 06:44 [medline]
PHST- 2024/02/05 06:43 [pubmed]
PHST- 2024/02/05 05:01 [entrez]
PHST- 2023/07/01 00:00 [pmc-release]
AID - 2023.3.15 [pii]
AID - 10.12865/CHSJ.49.03.15 [doi]
PST - ppublish
SO  - Curr Health Sci J. 2023 Jul-Sep;49(3):416-422. doi: 10.12865/CHSJ.49.03.15. Epub 
      2023 Sep 30.