PMID- 38315202
OWN - NLM
STAT- MEDLINE
DCOM- 20240427
LR  - 20240427
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 61
IP  - 5
DP  - 2024 May
TI  - Association of pro-inflammatory cytokines, adipokines and hepatokine with 
      incident diabetes in India: a nested case-control study within CARRS cohort.
PG  - 577-586
LID - 10.1007/s00592-023-02229-2 [doi]
AB  - AIMS: To study the association of pro-inflammatory markers with incident diabetes 
      in India. METHODS: We did a nested case-control study within the CARRS (Centre 
      for Ardiometabolic Risk Reduction in South Asia) cohort. Of the 5739 
      diabetes-free individuals at the baseline, 216 participants with incident 
      diabetes and 432 age-, gender- and city-matched controls at 2-year follow-up were 
      included. We measured high sensitive C-reactive protein (hsCRP), interleukin-6 
      (IL-6), tumor necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein-1 ( 
      MCP-1), adiponectin, leptin and fetuin-A in the stored baseline blood samples. We 
      did multivariate conditional logistic regression to estimate association of 
      inflammatory markers (as quartiles) and incident diabetes. Covariates were 
      baseline fasting plasma glucose (FPG) and lipids, body mass index (BMI), family 
      history of diabetes, smoking and alcohol use. RESULTS: Baseline hsCRP and TNF-alpha 
      were higher, and IL-6 and adiponectin were lower among cases vs. controls. In 
      multivariate conditional logistic regression models, only quartile-3 (odds ratio 
      [OR]: 2.96 [95% CI:1.39, 6.30]) and quartile-4 (OR: 2.58 [95% CI: 1.15, 5.79]) of 
      TNF-alpha and quartile-4 of MCP-1 (OR: 2.55 [95% CI: 1.06, 6.16]) were positively 
      associated with diabetes after adjusting for baseline FPG and BMI. These 
      associations did not remain after adjusting for family history. High level 
      (quartile-4) of IL-6 was negatively associated with diabetes after adjusting for 
      all factors (OR: 0.18 [95% CI: 0.06, 0.55]). CONCLUSIONS: Higher TNF-alpha and MCP-1 
      levels and lower IL-6 were associated with higher risk of developing diabetes. 
      Better understanding and potential methods of addressing these biomarkers, 
      especially in relation to family history, are needed to address diabetes in South 
      Asians.
CI  - (c) 2024. Springer-Verlag Italia S.r.l., part of Springer Nature.
FAU - Gupta, Ruby
AU  - Gupta R
AUID- ORCID: 0000-0002-8487-6004
AD  - Centre for Chronic Disease Control, New Delhi, India. ruby@ccdcindia.org.
FAU - Shivashankar, Roopa
AU  - Shivashankar R
AUID- ORCID: 0000-0002-4361-9423
AD  - Indian Council for Medical Research, New Delhi, India.
FAU - Kondal, Dimple
AU  - Kondal D
AUID- ORCID: 0000-0002-1417-9510
AD  - Centre for Chronic Disease Control, New Delhi, India.
FAU - Gokulakrishnan, Kuppan
AU  - Gokulakrishnan K
AUID- ORCID: 0000-0003-3167-8239
AD  - National Institute of Mental Health and NeuroSciences, Bangalore, India.
FAU - Patel, Shivani A
AU  - Patel SA
AUID- ORCID: 0000-0003-0082-5857
AD  - Rollins School of Public Health, Emory University, Atlanta, USA.
FAU - Ali, Mohammed K
AU  - Ali MK
AUID- ORCID: 0000-0001-7266-2503
AD  - Emory Global Diabetes Research Center, Emory University, Atlanta, USA.
AD  - Department of Family & Preventive Medicine, School of Medicine, Emory University, 
      Atlanta, USA.
FAU - Narayan, K M Venkat
AU  - Narayan KMV
AUID- ORCID: 0000-0001-8621-5405
AD  - Emory Global Diabetes Research Center, Woodruff Health Sciences Center, Emory 
      University, Atlanta, USA.
FAU - Mohan, Viswanathan
AU  - Mohan V
AUID- ORCID: 0000-0001-5038-6210
AD  - Madras Diabetes Research Foundation, Chennai, India.
FAU - Tandon, Nikhil
AU  - Tandon N
AUID- ORCID: 0000-0003-4604-1986
AD  - All India Institute of Medical Sciences, New Delhi, India.
FAU - Prabhakaran, Dorairaj
AU  - Prabhakaran D
AUID- ORCID: 0000-0002-3172-834X
AD  - Center for Chronic Disease Control, New Delhi, India.
LA  - eng
GR  - HHSN268200900026C/HL/NHLBI NIH HHS/United States
GR  - HHSN268200900026C/HL/NHLBI NIH HHS/United States
GR  - HHSN268200900026C/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20240205
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
RN  - 0 (Adipokines)
RN  - 0 (Cytokines)
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 0 (CCL2 protein, human)
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - Case-Control Studies
MH  - India/epidemiology
MH  - Middle Aged
MH  - *Adipokines/blood
MH  - Adult
MH  - Cytokines/blood
MH  - Diabetes Mellitus, Type 2/epidemiology/blood
MH  - Biomarkers/blood
MH  - Chemokine CCL2/blood
MH  - Interleukin-6/blood
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Cohort Studies
MH  - C-Reactive Protein/analysis
MH  - Incidence
OTO - NOTNLM
OT  - Adipokines
OT  - Cytokines
OT  - Hepatokines
OT  - Inflammation
OT  - Lipids
OT  - T2DM
OT  - hsCRP
EDAT- 2024/02/05 14:44
MHDA- 2024/04/28 07:24
CRDT- 2024/02/05 11:05
PHST- 2023/11/01 00:00 [received]
PHST- 2023/12/21 00:00 [accepted]
PHST- 2024/04/28 07:24 [medline]
PHST- 2024/02/05 14:44 [pubmed]
PHST- 2024/02/05 11:05 [entrez]
AID - 10.1007/s00592-023-02229-2 [pii]
AID - 10.1007/s00592-023-02229-2 [doi]
PST - ppublish
SO  - Acta Diabetol. 2024 May;61(5):577-586. doi: 10.1007/s00592-023-02229-2. Epub 2024 
      Feb 5.