PMID- 38315252 OWN - NLM STAT- Publisher LR - 20240205 IS - 1590-3478 (Electronic) IS - 1590-1874 (Linking) DP - 2024 Feb 5 TI - Overnight switch from carbamazepine to eslicarbazepine in a real-life clinical scenario: a retrospective study. LID - 10.1007/s10072-024-07354-6 [doi] AB - BACKGROUND: Carbamazepine (CBZ) is a first-choice anti-seizure medication (ASM) whose efficacy is often invalidated by adverse effects (AEs). Eslicarbazepine (ESL) is a structural derivative of CBZ with better pharmacokinetic/tolerability profiles. We describe our experience of the overnight CBZ to ESL switch in people with epilepsy (PwE) to improve seizure control, AEs, and ASMs adherence. METHODS: We retrospectively included 19 PwE (12 females, 53 +/- 21 years old) who underwent CBZ to ESL overnight switch due to single/multiple issues: poor efficacy (pEff, N = 8, 42%), tolerability (pToll, N = 11, 58%), adherence (pAdh, N = 2, 10%). 9/19 (47%) had psychiatric comorbidities. Clinical variables, seizure frequency, and AEs were recorded at switch time (T0) after 3.5 +/- 3 (T1) and 6.5 +/- 1.5 months (T2). RESULTS: At T1, in pEff group, 1/8 (13%) was seizure free, 2/8 (25%) were responders (> 50% seizure reduction), 2/8 (25%) had no seizure changes, 3/8 (37%) had seizure worsening; the latter were those with the most severe epilepsy and encephalopathy. In pToll group, all PwE experienced AEs disappearance/amelioration. In pAdh group, all PwE reported adherence amelioration. Four dropouts. At T2, no changes were recorded within groups, while in the whole sample, 6/15 (40%) were responders, and 4/15 (27%) were seizure-free. No one complained of Powered by Editorial Manager(R) and ProduXion Manager(R) from Aries Systems Corporation psychiatric worsening, while 6/19 (32%) experienced mood/behavior benefits. CONCLUSIONS: CBZ to ESL overnight switch offers an opportunity to improve efficacy, tolerability, adherence, and psychiatric symptoms. CI - (c) 2024. Fondazione Societa Italiana di Neurologia. FAU - Sancetta, Biagio Maria AU - Sancetta BM AUID- ORCID: 0009-0000-9624-6854 AD - UOC Neurologia, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128, Rome, Italy. biagio.sancetta@unicampus.it. AD - Research Unit of Neurology, Neurophysiology and Neurobiology, Department of Medicine and Surgery, Universita Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 21, 00128, Rome, Italy. biagio.sancetta@unicampus.it. FAU - Ricci, Lorenzo AU - Ricci L AD - UOC Neurologia, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128, Rome, Italy. AD - Research Unit of Neurology, Neurophysiology and Neurobiology, Department of Medicine and Surgery, Universita Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 21, 00128, Rome, Italy. FAU - Lanzone, Jacopo AU - Lanzone J AD - Istituti Clinici Scientifici Maugeri IRCCS, Neurorehabilitation Department of the Milano Institute, Milan, Italy. FAU - Boscarino, Marilisa AU - Boscarino M AD - Istituti Clinici Scientifici Maugeri IRCCS, Neurorehabilitation Department of the Milano Institute, Milan, Italy. FAU - Narducci, Flavia AU - Narducci F AD - UOC Neurologia, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128, Rome, Italy. AD - Research Unit of Neurology, Neurophysiology and Neurobiology, Department of Medicine and Surgery, Universita Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 21, 00128, Rome, Italy. FAU - Lippa, Giulia AU - Lippa G AD - UOC Neurologia, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128, Rome, Italy. AD - Research Unit of Neurology, Neurophysiology and Neurobiology, Department of Medicine and Surgery, Universita Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 21, 00128, Rome, Italy. FAU - Nesta, Marianna AU - Nesta M AD - UOC Neurologia, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128, Rome, Italy. AD - Research Unit of Neurology, Neurophysiology and Neurobiology, Department of Medicine and Surgery, Universita Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 21, 00128, Rome, Italy. FAU - Di Lazzaro, Vincenzo AU - Di Lazzaro V AD - UOC Neurologia, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128, Rome, Italy. AD - Research Unit of Neurology, Neurophysiology and Neurobiology, Department of Medicine and Surgery, Universita Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 21, 00128, Rome, Italy. FAU - Tombini, Mario AU - Tombini M AD - UOC Neurologia, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128, Rome, Italy. AD - Research Unit of Neurology, Neurophysiology and Neurobiology, Department of Medicine and Surgery, Universita Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 21, 00128, Rome, Italy. FAU - Assenza, Giovanni AU - Assenza G AD - UOC Neurologia, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128, Rome, Italy. AD - Research Unit of Neurology, Neurophysiology and Neurobiology, Department of Medicine and Surgery, Universita Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 21, 00128, Rome, Italy. LA - eng PT - Journal Article DEP - 20240205 PL - Italy TA - Neurol Sci JT - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JID - 100959175 SB - IM OTO - NOTNLM OT - Epilepsy OT - Eslicarbazepine acetate OT - Overnight switch EDAT- 2024/02/05 14:45 MHDA- 2024/02/05 14:45 CRDT- 2024/02/05 11:10 PHST- 2023/12/01 00:00 [received] PHST- 2024/01/22 00:00 [accepted] PHST- 2024/02/05 14:45 [medline] PHST- 2024/02/05 14:45 [pubmed] PHST- 2024/02/05 11:10 [entrez] AID - 10.1007/s10072-024-07354-6 [pii] AID - 10.1007/s10072-024-07354-6 [doi] PST - aheadofprint SO - Neurol Sci. 2024 Feb 5. doi: 10.1007/s10072-024-07354-6.