PMID- 38315632
OWN - NLM
STAT- Publisher
LR  - 20240205
IS  - 2325-6621 (Electronic)
IS  - 2325-6621 (Linking)
DP  - 2024 Feb 5
TI  - Validation of a Dyspnea Visual Analogue Scale in Fibrotic Interstitial Lung 
      Disease.
LID - 10.1513/AnnalsATS.202307-658OC [doi]
AB  - RATIONALE: A visual analogue scale (VAS) is a simple and easily administered tool 
      for measuring impact of disease; however, little is known about the use of a 
      Dyspnea VAS in interstitial lung disease (ILD). OBJECTIVE: To validate the use of 
      a Dyspnea VAS in a large and heterogenous cohort of patients with fibrotic ILD, 
      including its minimal clinically important difference (MCID), responsiveness to 
      change, and prognostic significance. METHODS: Patients with fibrotic ILD were 
      identified from a large prospective registry. Validity of a 100mm Dyspnea VAS was 
      assessed by testing its correlation in change score with other measures of ILD 
      severity, including the University of California San Diego Shortness of Breath 
      Questionnaire (UCSDSOBQ), King's Brief Interstitial Lung Disease quality of life 
      questionnaire Breathlessness and Activities Domain (KBILD-B), European Quality of 
      Life visual analogue scale (EQ-VAS), forced vital capacity (FVC), and diffusion 
      capacity of the lung for carbon monoxide (DLCO). Responsiveness of the Dyspnea 
      VAS was qualitatively confirmed based on there being an observable difference in 
      the change in Dyspnea VAS across tertiles of change in anchor variables. The 
      minimum clinically important difference (MCID) in Dyspnea VAS was calculated 
      using both anchor (linear regression) and distribution (one-half standard 
      deviation) approaches, with anchors including the above variables that had a 
      correlation with Dyspnea VAS (|r|0.30). The association of Dyspnea VAS with time 
      to death or transplant was determined. RESULTS: The cohort included 826 patients 
      with fibrotic ILD, including 127 patients with follow-up measurements at 6 
      months. Mean baseline Dyspnea VAS was 5324mm. Dyspnea VAS change scores were 
      moderately correlated with UCSDSOBQ (|r|=0.55) and KBILD-B (|r|=0.44), and weakly 
      correlated with EQ-VAS (|r|=0.19), FVC% (|r|=0.21) and DLCO% (|r|=0.05). MCID was 
      2.7 to 4.5 using the more reliable anchor-based methods and 12.0 based on 
      distribution-based methods. Dyspnea VAS was associated with time to death or 
      transplant in unadjusted models and after adjustment for age and sex (hazard 
      ratio 1.16 and 1.15 respectively, p<0.05 for both). CONCLUSION: This study 
      provides support for the use of Dyspnea VAS in patients with fibrotic ILD, with 
      an estimated anchor-based MCID of 5mm.
FAU - Bevanda, Luka
AU  - Bevanda L
AD  - University of British Columbia, Medicine, Vancouver, British Columbia, Canada.
FAU - Mok, Valerie
AU  - Mok V
AD  - University of British Columbia, Medicine, Vancouver, British Columbia, Canada.
FAU - Lin, Kenny
AU  - Lin K
AD  - University of British Columbia, Medicine, Vancouver, British Columbia, Canada.
FAU - Assayag, Deborah
AU  - Assayag D
AD  - McGill University, Medicine, Montreal, Quebec, Canada.
FAU - Fisher, Jolene H
AU  - Fisher JH
AD  - University of Toronto, Medicine, Toronto, Ontario, Canada.
FAU - Johannson, Kerri A
AU  - Johannson KA
AD  - University of Calgary, Calgary, Alberta, Canada.
FAU - Khalil, Nasreen
AU  - Khalil N
AD  - University of British Columbia, Medicine, Vancouver, British Columbia, Canada.
FAU - Kolb, Martin
AU  - Kolb M
AUID- ORCID: 0000-0003-3837-1467
AD  - McMaster University, Hamilton, Ontario, Canada.
FAU - Manganas, Helene
AU  - Manganas H
AD  - Centre Hospitalier de l'Universite de Montreal Bibliotheque, 514987, Departement 
      de Medecine, Montreal, Quebec, Canada.
FAU - Marcoux, Veronica
AU  - Marcoux V
AD  - University of Saskatchewan, 7235, Medicine, Saskatoon, Saskatchewan, Canada.
FAU - Sadatsafavi, Mohsen
AU  - Sadatsafavi M
AD  - University of British Columbia, Institute for Heart and Lung Health, Vancouver, 
      British Columbia, Canada.
FAU - Wong, Alyson W
AU  - Wong AW
AD  - University of British Columbia Faculty of Medicine, 12358, Vancouver, Canada.
FAU - Ryerson, Christopher J
AU  - Ryerson CJ
AD  - University of British Columbia, Medicine, Vancouver, British Columbia, Canada; 
      chris.ryerson@hli.ubc.ca.
LA  - eng
PT  - Journal Article
DEP - 20240205
PL  - United States
TA  - Ann Am Thorac Soc
JT  - Annals of the American Thoracic Society
JID - 101600811
SB  - IM
EDAT- 2024/02/05 14:45
MHDA- 2024/02/05 14:45
CRDT- 2024/02/05 13:13
PHST- 2024/02/05 14:45 [medline]
PHST- 2024/02/05 14:45 [pubmed]
PHST- 2024/02/05 13:13 [entrez]
AID - 10.1513/AnnalsATS.202307-658OC [doi]
PST - aheadofprint
SO  - Ann Am Thorac Soc. 2024 Feb 5. doi: 10.1513/AnnalsATS.202307-658OC.