PMID- 38316761
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240210
IS  - 2058-7716 (Print)
IS  - 2058-7716 (Electronic)
IS  - 2058-7716 (Linking)
VI  - 10
IP  - 1
DP  - 2024 Feb 5
TI  - Cellular senescence of renal tubular epithelial cells in acute kidney injury.
PG  - 62
LID - 10.1038/s41420-024-01831-9 [doi]
LID - 62
AB  - Cellular senescence represents an irreversible state of cell-cycle arrest during 
      which cells secrete senescence-associated secretory phenotypes, including 
      inflammatory factors and chemokines. Additionally, these cells exhibit an 
      apoptotic resistance phenotype. Cellular senescence serves a pivotal role not 
      only in embryonic development, tissue regeneration, and tumor suppression but 
      also in the pathogenesis of age-related degenerative diseases, malignancies, 
      metabolic diseases, and kidney diseases. The senescence of renal tubular 
      epithelial cells (RTEC) constitutes a critical cellular event in the progression 
      of acute kidney injury (AKI). RTEC senescence inhibits renal regeneration and 
      repair processes and, concurrently, promotes the transition of AKI to chronic 
      kidney disease via the senescence-associated secretory phenotype. The mechanisms 
      underlying cellular senescence are multifaceted and include telomere shortening 
      or damage, DNA damage, mitochondrial autophagy deficiency, cellular metabolic 
      disorders, endoplasmic reticulum stress, and epigenetic regulation. Strategies 
      aimed at inhibiting RTEC senescence, targeting the clearance of senescent RTEC, 
      or promoting the apoptosis of senescent RTEC hold promise for enhancing the renal 
      prognosis of AKI. This review primarily focuses on the characteristics and 
      mechanisms of RTEC senescence, and the impact of intervening RTEC senescence on 
      the prognosis of AKI, aiming to provide a foundation for understanding the 
      pathogenesis and providing potentially effective approaches for AKI treatment.
CI  - (c) 2024. The Author(s).
FAU - Chen, Juan
AU  - Chen J
AD  - Department of Nephrology, Daping Hospital, Army Medical University, 400042, 
      Chongqing, China.
FAU - Zhang, Huhai
AU  - Zhang H
AD  - Department of Nephrology, Southwest Hospital, Army Medical University, 400042, 
      Chongqing, China.
FAU - Yi, Xiangling
AU  - Yi X
AD  - Department of Nephrology, Daping Hospital, Army Medical University, 400042, 
      Chongqing, China.
FAU - Dou, Qian
AU  - Dou Q
AD  - Department of Nephrology, Daping Hospital, Army Medical University, 400042, 
      Chongqing, China.
FAU - Yang, Xin
AU  - Yang X
AD  - Department of Nephrology, Daping Hospital, Army Medical University, 400042, 
      Chongqing, China.
FAU - He, Yani
AU  - He Y
AD  - Department of Nephrology, Daping Hospital, Army Medical University, 400042, 
      Chongqing, China.
FAU - Chen, Jia
AU  - Chen J
AD  - Department of Nephrology, Daping Hospital, Army Medical University, 400042, 
      Chongqing, China. chenjiasnk@163.com.
FAU - Chen, Kehong
AU  - Chen K
AD  - Department of Nephrology, Daping Hospital, Army Medical University, 400042, 
      Chongqing, China. kehong_chen@126.com.
AD  - State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical 
      University, Chongqing, China. kehong_chen@126.com.
LA  - eng
GR  - No. SKLKF202202/Third Military Medical University (TMMU)/
GR  - No. 82270768/National Natural Science Foundation of China (National Science 
      Foundation of China)/
PT  - Journal Article
PT  - Review
DEP - 20240205
PL  - United States
TA  - Cell Death Discov
JT  - Cell death discovery
JID - 101665035
PMC - PMC10844256
COIS- All authors declare no conflict of interest. They declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/02/06 00:42
MHDA- 2024/02/06 00:43
PMCR- 2024/02/05
CRDT- 2024/02/05 23:24
PHST- 2023/11/19 00:00 [received]
PHST- 2024/01/24 00:00 [accepted]
PHST- 2024/01/14 00:00 [revised]
PHST- 2024/02/06 00:43 [medline]
PHST- 2024/02/06 00:42 [pubmed]
PHST- 2024/02/05 23:24 [entrez]
PHST- 2024/02/05 00:00 [pmc-release]
AID - 10.1038/s41420-024-01831-9 [pii]
AID - 1831 [pii]
AID - 10.1038/s41420-024-01831-9 [doi]
PST - epublish
SO  - Cell Death Discov. 2024 Feb 5;10(1):62. doi: 10.1038/s41420-024-01831-9.