PMID- 38317961
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240207
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 10
IP  - 3
DP  - 2024 Feb 15
TI  - Nicotinamide adenine dinucleotide phosphate oxidase 2 deletion attenuates 
      polyhexamethylene guanidine-induced lung injury in mice.
PG  - e25045
LID - 10.1016/j.heliyon.2024.e25045 [doi]
LID - e25045
AB  - Inhalation of polyhexamethylene guanidine phosphate (PHMG) can cause pulmonary 
      fibrosis. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Nox) are 
      enzymes that produce reactive oxygen species, which may be involved in tissue 
      damage in various lung diseases. To investigate whether the Nox2 isoform of Nox 
      is involved in the progression of PHMG-induced lung damage, we studied the 
      contribution of Nox2 in PHMG-induced lung injury in Nox2-deficient mice. We 
      treated wild-type (WT) and Nox2 knockout mice with a single intratracheal 
      instillation of 1.1 mg/kg PHMG and sacrificed them after 14 days. We analyzed 
      lung histopathology and the number of total and differential cells in the 
      bronchoalveolar lavage fluid. In addition, the expressions of cytokines, 
      chemokines, and profibrogenic genes were analyzed in the lung tissues. Based on 
      our results, Nox2-deficient mice showed less PHMG-induced pulmonary damage than 
      WT mice, as indicated by parameters such as body weight, lung weight, total cell 
      count, cytokine and chemokine levels, fibrogenic mediator expression, and 
      histopathological findings. These findings suggest that Nox2 may have the 
      potential to contribute to PHMG-induced lung injury and serves as an essential 
      signaling molecule in the development of PHMG-induced pulmonary fibrosis by 
      regulating the expression of profibrogenic genes.
CI  - (c) 2024 Published by Elsevier Ltd.
FAU - Cho, Yoon
AU  - Cho Y
AD  - Inhalation Toxicology Research Group, Korea Institute of Toxicology, Jeongeup-si, 
      Jeollabuk-do, 56212, Republic of Korea.
FAU - Jeon, Seulgi
AU  - Jeon S
AD  - Inhalation Toxicology Research Group, Korea Institute of Toxicology, Jeongeup-si, 
      Jeollabuk-do, 56212, Republic of Korea.
FAU - Kim, Sung-Hwan
AU  - Kim SH
AD  - Human Health Risk Assessment Center, Korea Institute of Toxicology, Jeongeup-si, 
      Jeollabuk-do, 56212, Republic of Korea.
FAU - Kim, Hyeon-Young
AU  - Kim HY
AD  - Human Health Risk Assessment Center, Korea Institute of Toxicology, Jeongeup-si, 
      Jeollabuk-do, 56212, Republic of Korea.
FAU - Kim, Bumseok
AU  - Kim B
AD  - Biosafety Research Institute and Laboratory of Veterinary Pathology, College of 
      Veterinary Medicine, Jeonbuk National University, 79 Gobong-Ro, Iksan-Si, 
      Jeollabuk-Do, 54596, Republic of Korea.
FAU - Yang, Mi-Jin
AU  - Yang MJ
AD  - Pathology Research Group, Korea Institute of Toxicology, Jeongeup-si, 
      Jeollabuk-do, 56212, Republic of Korea.
FAU - Rho, Jinhyung
AU  - Rho J
AD  - Pathology Research Group, Korea Institute of Toxicology, Jeongeup-si, 
      Jeollabuk-do, 56212, Republic of Korea.
FAU - Lee, Moo-Yeol
AU  - Lee MY
AD  - College of Pharmacy, Dongguk University, Goyang-si, Gyeonggi-do, 10326, Republic 
      of Korea.
FAU - Lee, Kyuhong
AU  - Lee K
AD  - Inhalation Toxicology Center for Airborne Risk Factor, Korea Institute of 
      Toxicology, 30 Baehak1-gil, Jeongeup, Jeollabuk-do, 56212, Republic of Korea.
AD  - Department of Human and Environmental Toxicology, University of Science & 
      Technology, Daejeon, 34113, Republic of Korea.
FAU - Kim, Min-Seok
AU  - Kim MS
AD  - Inhalation Toxicology Research Group, Korea Institute of Toxicology, Jeongeup-si, 
      Jeollabuk-do, 56212, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20240123
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC10838801
OTO - NOTNLM
OT  - Lung injury
OT  - NADPH oxidases 2
OT  - Polyhexamethylene guanidine
OT  - Pulmonary fibrosis
OT  - Reactive oxygen species
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2024/02/06 06:42
MHDA- 2024/02/06 06:43
PMCR- 2024/01/23
CRDT- 2024/02/06 03:50
PHST- 2023/07/11 00:00 [received]
PHST- 2024/01/16 00:00 [revised]
PHST- 2024/01/18 00:00 [accepted]
PHST- 2024/02/06 06:43 [medline]
PHST- 2024/02/06 06:42 [pubmed]
PHST- 2024/02/06 03:50 [entrez]
PHST- 2024/01/23 00:00 [pmc-release]
AID - S2405-8440(24)01076-4 [pii]
AID - e25045 [pii]
AID - 10.1016/j.heliyon.2024.e25045 [doi]
PST - epublish
SO  - Heliyon. 2024 Jan 23;10(3):e25045. doi: 10.1016/j.heliyon.2024.e25045. 
      eCollection 2024 Feb 15.