PMID- 38318092
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240207
IS  - 2288-6575 (Print)
IS  - 2288-6796 (Electronic)
IS  - 2288-6575 (Linking)
VI  - 106
IP  - 2
DP  - 2024 Feb
TI  - Risk factors for incisional hernia after liver transplantation in the era of 
      mammalian target of rapamycin inhibitors use: a retrospective study of living 
      donor liver transplantation dominant center in Korea.
PG  - 115-123
LID - 10.4174/astr.2024.106.2.115 [doi]
AB  - PURPOSE: Incisional hernia (IH) is a common complication after liver 
      transplantation (LT) with an incidence rate of 5% to 46%. This retrospective 
      study aimed to evaluate the risk factors for IH development after LT in the era 
      of mammalian target of rapamycin (mTOR) inhibitors use. METHODS: Data on patients 
      who underwent LT between 2015 and 2021 were retrospectively reviewed. The 
      patients were divided into 2 groups (IH group and non-IH group) according to the 
      postoperative occurrence of IH. RESULTS: We analyzed data from 878 patients 
      during the study period, with 28 patients (3.2%) developing IH. According to 
      multivariate analysis, body mass index exceeding 25 kg/m(2) and the use of mTOR 
      inhibitors within the first month after LT were the sole significant factors for 
      both IH occurrence and the subsequent need for repair operations. Notably, a 
      history of wound complications, a Model for End-stage Liver Disease score, and 
      the timing of LT-whether conducted during regular hours or at night-did not 
      emerge as significant risk factors for IH after LT. CONCLUSION: Our study reveals 
      a higher incidence of IH among obese patients following LT, often requiring 
      surgical repair, particularly in cases involving mTOR inhibitor usage within the 
      initial month after LT. Consequently, it is crucial to exercise increased 
      vigilance, especially in obese patients, and exercise caution when considering 
      early mTOR inhibitor administration after LT.
CI  - Copyright (c) 2024, the Korean Surgical Society.
FAU - Kim, Jae-Yoon
AU  - Kim JY
AUID- ORCID: 0000-0002-2546-3752
AD  - Department of Surgery, Seoul National University College of Medicine, Seoul, 
      Korea.
FAU - Hong, Suk Kyun
AU  - Hong SK
AUID- ORCID: 0000-0002-0020-6215
AD  - Department of Surgery, Seoul National University College of Medicine, Seoul, 
      Korea.
FAU - Kim, Jiyoung
AU  - Kim J
AUID- ORCID: 0000-0001-7464-8836
AD  - Department of Surgery, Seoul National University College of Medicine, Seoul, 
      Korea.
FAU - Choi, Hyun Hwa
AU  - Choi HH
AUID- ORCID: 0000-0003-1476-5410
AD  - Department of Surgery, Seoul National University College of Medicine, Seoul, 
      Korea.
FAU - Lee, Jaewon
AU  - Lee J
AUID- ORCID: 0000-0002-0248-5553
AD  - Department of Surgery, Seoul National University College of Medicine, Seoul, 
      Korea.
FAU - Hong, Su Young
AU  - Hong SY
AUID- ORCID: 0000-0002-9934-0456
AD  - Department of Surgery, Seoul National University College of Medicine, Seoul, 
      Korea.
FAU - Lee, Jeong-Moo
AU  - Lee JM
AUID- ORCID: 0000-0001-7806-8759
AD  - Department of Surgery, Seoul National University College of Medicine, Seoul, 
      Korea.
FAU - Choi, YoungRok
AU  - Choi Y
AUID- ORCID: 0000-0003-2408-7086
AD  - Department of Surgery, Seoul National University College of Medicine, Seoul, 
      Korea.
FAU - Yi, Nam-Joon
AU  - Yi NJ
AUID- ORCID: 0000-0002-5467-425X
AD  - Department of Surgery, Seoul National University College of Medicine, Seoul, 
      Korea.
FAU - Lee, Kwang-Woong
AU  - Lee KW
AUID- ORCID: 0000-0001-6412-1926
AD  - Department of Surgery, Seoul National University College of Medicine, Seoul, 
      Korea.
FAU - Suh, Kyung-Suk
AU  - Suh KS
AUID- ORCID: 0000-0002-9535-7349
AD  - Department of Surgery, Seoul National University College of Medicine, Seoul, 
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20240129
PL  - Korea (South)
TA  - Ann Surg Treat Res
JT  - Annals of surgical treatment and research
JID - 101622895
PMC - PMC10838656
OTO - NOTNLM
OT  - Incisional hernia
OT  - Liver transplantation
OT  - mTOR inhibitors
COIS- Conflict of Interest: No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2024/02/06 06:43
MHDA- 2024/02/06 06:44
PMCR- 2024/02/01
CRDT- 2024/02/06 03:51
PHST- 2023/08/24 00:00 [received]
PHST- 2023/10/31 00:00 [revised]
PHST- 2023/11/26 00:00 [accepted]
PHST- 2024/02/06 06:44 [medline]
PHST- 2024/02/06 06:43 [pubmed]
PHST- 2024/02/06 03:51 [entrez]
PHST- 2024/02/01 00:00 [pmc-release]
AID - 10.4174/astr.2024.106.2.115 [doi]
PST - ppublish
SO  - Ann Surg Treat Res. 2024 Feb;106(2):115-123. doi: 10.4174/astr.2024.106.2.115. 
      Epub 2024 Jan 29.