PMID- 38318717
OWN - NLM
STAT- MEDLINE
DCOM- 20240411
LR  - 20240411
IS  - 1097-0010 (Electronic)
IS  - 0022-5142 (Linking)
VI  - 104
IP  - 7
DP  - 2024 May
TI  - Ethanol extracts of Isochrysis zhanjiangensis alleviate acute alcoholic liver 
      injury and modulate intestinal bacteria dysbiosis in mice.
PG  - 4354-4362
LID - 10.1002/jsfa.13321 [doi]
AB  - BACKGROUND: Alcoholic liver disease (ALD) is responsible for 3.3 million deaths 
      per annum. Efficacious therapeutic modalities or drug treatments for ALD have not 
      yet been found, so it is urgent to seek new agents for preventing ALD and its 
      related disease. Many experiments have indicated that modulating the gut 
      microbiota and regulating the toll-like receptor 4 (TLR(4))/nuclear transcription 
      factor-kappaB (NF-kappaB) inflammatory pathway can provide a new target for prevention 
      and treatment of ALD. Marine microalgae have their natural metabolic pathways to 
      synthesize various of bioactive compounds as promising candidates for 
      hepatoprotection. In this study, we investigated ethanol extracts from Isochrysis 
      zhanjiangensis (EEIZ) to evaluate their ability to alleviate acute alcoholic 
      liver injury, regulate TLR(4)/NF-kappaB inflammatory pathway and modulate intestinal 
      bacteria dysbiosis in mice for ALD treatment. RESULTS: In the acute ALD mouse 
      model, EEIZ reduced levels of aspartate aminotransferase, alanine 
      aminotransferase, alkaline phosphatase, triacylglyceride, total cholesterol and 
      low-density lipoprotein, while increasing the level of high-density lipoprotein. 
      Besides, TLR(4), myeloid differentiation factor 88, NF-kappaB and tumor necrosis 
      factor-alpha expression levels in liver tissue were effectively downregulated by 
      EEIZ. Furthermore, treatment with EEIZ enhanced intestinal homeostasis and 
      significantly alleviated the damage caused by alcohol. CONCLUSION: EEIZ showed 
      effective hepatoprotective activity against alcohol-induced acute liver injury in 
      mice as it could alleviate hepatocyte damage, suppress the TLR(4)/NF-kappaB 
      inflammatory pathway and regulate the intestinal flora structure. EEIZ could be a 
      good candidate for preventing acute alcoholic liver injury. (c) 2024 Society of 
      Chemical Industry.
CI  - (c) 2024 Society of Chemical Industry.
FAU - Wen, Yangmin
AU  - Wen Y
AD  - Department of basic medical science, Quanzhou Medical College, Quanzhou, China.
FAU - Zhou, Youcai
AU  - Zhou Y
AUID- ORCID: 0009-0007-5243-749X
AD  - School of Food and Biological Engineering, Fujian Polytechnic Normal University, 
      Fuqing, China.
FAU - Tian, Li
AU  - Tian L
AD  - Department of basic medical science, Quanzhou Medical College, Quanzhou, China.
FAU - He, Yongjin
AU  - He Y
AD  - College of Life Science, Fujian Normal University, Fuzhou, China.
AD  - Engineering Research Center of Industrial Microbiology, Ministry of Education, 
      Fujian Normal University, Fuzhou, China.
LA  - eng
GR  - Key Projects of Fujian Provincial Department of Ecology and Environment of China 
      (2023R0001)/
GR  - Open-ended Project of Carbon Neutral Research Institue, Fujian Normal University 
      (TZH-2022-03)/
GR  - Key Projects of Departmen of Education of Fujian Province of China (2022G02013)/
GR  - Education and research projects for young and middle-aged teachers of Fujian 
      province (JAT210896)/
PT  - Journal Article
DEP - 20240206
PL  - England
TA  - J Sci Food Agric
JT  - Journal of the science of food and agriculture
JID - 0376334
RN  - 3K9958V90M (Ethanol)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (NF-kappa B)
SB  - IM
MH  - Mice
MH  - Animals
MH  - Ethanol/metabolism
MH  - Toll-Like Receptor 4/genetics/metabolism/therapeutic use
MH  - *Haptophyta/metabolism
MH  - NF-kappa B/genetics/metabolism
MH  - Dysbiosis/drug therapy/metabolism
MH  - Liver/metabolism
MH  - *Liver Diseases, Alcoholic/etiology
MH  - Bacteria/metabolism
MH  - Mice, Inbred C57BL
OTO - NOTNLM
OT  - Isochrysis zhanjiangensis
OT  - TLR4/NF-kappaB pathway
OT  - alcoholic liver disease
OT  - ethanol extracts
OT  - intestinal flora
EDAT- 2024/02/06 06:42
MHDA- 2024/04/11 06:43
CRDT- 2024/02/06 05:31
PHST- 2024/01/14 00:00 [revised]
PHST- 2023/08/07 00:00 [received]
PHST- 2024/01/19 00:00 [accepted]
PHST- 2024/04/11 06:43 [medline]
PHST- 2024/02/06 06:42 [pubmed]
PHST- 2024/02/06 05:31 [entrez]
AID - 10.1002/jsfa.13321 [doi]
PST - ppublish
SO  - J Sci Food Agric. 2024 May;104(7):4354-4362. doi: 10.1002/jsfa.13321. Epub 2024 
      Feb 6.