PMID- 38318910 OWN - NLM STAT- MEDLINE DCOM- 20240207 LR - 20240219 IS - 1671-167X (Print) IS - 1671-167X (Linking) VI - 56 IP - 1 DP - 2024 Feb 18 TI - [Index of microcirculatory resistance is associated with left ventricular remodeling in patients with acute anterior ST-segment elevation myocardial infarction undergoing emergency primary percutaneous coronary intervention]. PG - 150-156 AB - OBJECTIVE: To evaluate whether index of microcirculatory resistance (IMR) is associated with left ventricular (LV) remodeling in acute anterior ST elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PPCI). METHODS: This was a single-center retrospective cohort study. The patients with first anterior STEMI who received PPCI from January 2014 to August 2017 in Peking University Third Hospital was enrolled. After PPCI, IMR was measured immediately by using pressure/temperature guidewire. The success rate of IMR measurement was 100%. Also we collected some related clinical data from the medical records and laboratory results. Infarct size [assessed as creatine kinase (CK) peak], echocardiography at baseline and 1 year follow-up were assessed. LV adverse remodeling (LVAR) was defined as >/=20% increase in LV end-diastolic volume (LVEDV). RESULTS: A total of forty-three patients were enrolled, with an average age of (58.7+/-12.4) years.The patients were divided into two groups as IMR 25 by normal values recommended by previous literature. Compared with IMR 25 group had a higher percentage of initial thrombolysis in myocardial infraction (TIMI) grade 0 (95.7% vs. 65.0%, P=0.029), higher serum CK peak value [4 090 (383, 15 833)vs. 1 580 (396, 5 583), P=0.004]. The IMR>25 group suffered higher rates of ventricular aneurysm (30.4% vs. 5.0%, P=0.021). There was no difference in LVEDV [(111.0+/-18.8) mL vs. (115.0+/-23.6) mL, P=0.503] between the two groups 1 day after MI, but after 1 year, LVEDV in IMR>25 group was significantly higher than in IMR25 group (47.4% vs. 11.8%, P=0.024). Binary Logistics regression showed that IMR [B=0.079, exp(B) (95%CI)=1.082 (1.018－1.149), P=0.011] and serum triglyceride level [B=1.610, exp(B) (95%CI)=5.005 (1.380－18.152), P=0.014] were the predictors of LVAR 1 year after MI. IMR had a good predictive value for LVAR 1 year after MI [area under the curve (AUC)=0.749, P=0.019], IMR>29 was a good cutoff value with sensitivity 81.8% and specificity 68.0%. CONCLUSION: Our study elaborates that immediate measurement of IMR after PPCI in patients with STEMI can reflect the microvascular function.And IMR could be used as a quantitative biomarker to predict LVAR after STEMI. FAU - Wang, Fangfang AU - Wang F AD - Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China. FAU - Liang, Fumeng AU - Liang F AD - Department of General Medicine, Peking University Third Hospital, Beifang Branch, Beijing 100089, China. FAU - Li, Nan AU - Li N AD - Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, China. FAU - Wang, Xiaoxiao AU - Wang X AD - Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, China. FAU - Han, Jiangli AU - Han J AD - Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China. FAU - Guo, Lijun AU - Guo L AD - Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China. LA - chi PT - English Abstract PT - Journal Article PL - China TA - Beijing Da Xue Xue Bao Yi Xue Ban JT - Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences JID - 101125284 SB - IM MH - Humans MH - Middle Aged MH - Aged MH - *ST Elevation Myocardial Infarction/surgery MH - Retrospective Studies MH - Microcirculation MH - Ventricular Remodeling MH - Treatment Outcome MH - Ventricular Function, Left MH - *Percutaneous Coronary Intervention PMC - PMC10845173 OTO - NOTNLM OT - Acute myocardial infarction OT - Index of microcirculatory resistance OT - LV adverse remodeling OT - Triglyceride COIS- 利益冲突 所有作者均声明不存在利益冲突。 EDAT- 2024/02/06 13:19 MHDA- 2024/02/07 06:42 PMCR- 2024/02/18 CRDT- 2024/02/06 08:20 PHST- 2024/02/07 06:42 [medline] PHST- 2024/02/06 13:19 [pubmed] PHST- 2024/02/06 08:20 [entrez] PHST- 2024/02/18 00:00 [pmc-release] AID - bjdxxbyxb-56-1-150 [pii] AID - 10.19723/j.issn.1671-167X.2024.01.023 [doi] PST - ppublish SO - Beijing Da Xue Xue Bao Yi Xue Ban. 2024 Feb 18;56(1):150-156. doi: 10.19723/j.issn.1671-167X.2024.01.023.