PMID- 38321630
OWN - NLM
STAT- MEDLINE
DCOM- 20240314
LR  - 20240314
IS  - 1939-165X (Electronic)
IS  - 0275-6382 (Linking)
VI  - 53
IP  - 1
DP  - 2024 Mar
TI  - Development of a reference interval for urinary ammonia-to-creatinine ratio in 
      feline patients.
PG  - 136-140
LID - 10.1111/vcp.13327 [doi]
AB  - BACKGROUND: Disruption of acid-base homeostasis can lead to many clinical 
      problems. Ammonia excretion by the kidneys is critical to maintaining acid-base 
      homeostasis through bicarbonate production. Measurement of ammonia excretion may 
      help determine if the kidneys are properly functioning in maintaining acid-base 
      balance. Reference intervals are essential tools for clinical decision-making but 
      do not currently exist for urinary ammonia-to-creatinine ratio (UACR) in feline 
      patients. OBJECTIVE: This study aimed to generate a reference interval (RI) for 
      UACR in healthy adult cats. METHODS: The study used samples from client-owned 
      adult healthy cats that presented to the University of Florida Primary Care and 
      Dentistry service (n = 92). Physical examination, serum biochemistry, urinalysis, 
      urine ammonia, and creatinine concentrations were measured. Cats were excluded if 
      there were significant abnormalities in their urinalysis or biochemistry panel. 
      The RI for UACR was calculated according to the recommendation of the American 
      Society for Veterinary Clinical Pathology. The UACR was evaluated for correlation 
      with serum bicarbonate, weight, age, and sex. RESULTS: The RI for UACR was 
      3.4-20.7 with 90% confidence intervals for the lower and upper limits of 
      (3.0-3.7) and (16.0-23.7), respectively. No significant correlation with age, 
      sex, or weight was found. There was no discernable relationship between serum 
      bicarbonate and UACR. CONCLUSIONS: Establishing an RI for UACR in healthy adult 
      cats will allow further studies to determine if changes in UACR are observed 
      during specific disease states.
CI  - (c) 2024 The Authors. Veterinary Clinical Pathology published by Wiley Periodicals 
      LLC on behalf of American Society for Veterinary Clinical Pathology.
FAU - Brown, Eleanor E
AU  - Brown EE
AD  - Department of Small Animal Clinical Science, University of Florida College of 
      Veterinary Medicine, Gainesville, Florida, USA.
FAU - Castro, Rebecca A
AU  - Castro RA
AD  - Department of Small Animal Clinical Science, University of Florida College of 
      Veterinary Medicine, Gainesville, Florida, USA.
FAU - Griffin, Francesca C
AU  - Griffin FC
AD  - Department of Small Animal Clinical Science, University of Florida College of 
      Veterinary Medicine, Gainesville, Florida, USA.
FAU - Mandese, Wendy W
AU  - Mandese WW
AD  - Department of Small Animal Clinical Science, University of Florida College of 
      Veterinary Medicine, Gainesville, Florida, USA.
FAU - Rooks, Jenna K
AU  - Rooks JK
AD  - Department of Small Animal Clinical Science, University of Florida College of 
      Veterinary Medicine, Gainesville, Florida, USA.
FAU - Stone, Amy E
AU  - Stone AE
AD  - Department of Small Animal Clinical Science, University of Florida College of 
      Veterinary Medicine, Gainesville, Florida, USA.
FAU - Wuerz, Julia A
AU  - Wuerz JA
AD  - Department of Small Animal Clinical Science, University of Florida College of 
      Veterinary Medicine, Gainesville, Florida, USA.
FAU - Cooke, Kirsten L
AU  - Cooke KL
AD  - Department of Small Animal Clinical Science, University of Florida College of 
      Veterinary Medicine, Gainesville, Florida, USA.
FAU - Specht, Andrew J
AU  - Specht AJ
AD  - Department of Small Animal Clinical Science, University of Florida College of 
      Veterinary Medicine, Gainesville, Florida, USA.
FAU - Harris, Autumn N
AU  - Harris AN
AUID- ORCID: 0000-0002-2329-3905
AD  - Department of Small Animal Clinical Science, University of Florida College of 
      Veterinary Medicine, Gainesville, Florida, USA.
AD  - Division of Nephrology, Hypertension and Renal Transplantation, University of 
      Florida College of Medicine, Gainesville, Florida, USA.
LA  - eng
GR  - University of Florida/
PT  - Journal Article
DEP - 20240206
PL  - United States
TA  - Vet Clin Pathol
JT  - Veterinary clinical pathology
JID - 9880575
RN  - AYI8EX34EU (Creatinine)
RN  - 7664-41-7 (Ammonia)
RN  - 0 (Bicarbonates)
SB  - IM
MH  - Cats
MH  - Animals
MH  - Creatinine/urine
MH  - *Ammonia
MH  - Bicarbonates
MH  - Urinalysis/veterinary
MH  - Kidney
MH  - Albuminuria/urine/veterinary
MH  - *Cat Diseases
OTO - NOTNLM
OT  - acid-base
OT  - assay
OT  - feline
OT  - kidney
OT  - renal physiology
EDAT- 2024/02/07 06:43
MHDA- 2024/03/14 06:46
CRDT- 2024/02/07 00:23
PHST- 2023/11/01 00:00 [revised]
PHST- 2023/08/15 00:00 [received]
PHST- 2023/12/14 00:00 [accepted]
PHST- 2024/03/14 06:46 [medline]
PHST- 2024/02/07 06:43 [pubmed]
PHST- 2024/02/07 00:23 [entrez]
AID - 10.1111/vcp.13327 [doi]
PST - ppublish
SO  - Vet Clin Pathol. 2024 Mar;53(1):136-140. doi: 10.1111/vcp.13327. Epub 2024 Feb 6.