PMID- 38322127 OWN - NLM STAT- MEDLINE DCOM- 20240208 LR - 20240429 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 12 DP - 2024 TI - Causal association of leisure sedentary behavior and cervical spondylosis, sciatica, intervertebral disk disorders, and low back pain: a Mendelian randomization study. PG - 1284594 LID - 10.3389/fpubh.2024.1284594 [doi] LID - 1284594 AB - BACKGROUND: Some studies suggest sedentary behavior is a risk factor for musculoskeletal disorders. This study aimed to investigate the potential causal association between leisure sedentary behavior (LSB) (including television (TV) viewing, computer use, and driving) and the incidence of sciatica, intervertebral disk degeneration (IVDD), low back pain (LBP), and cervical spondylosis (CS). METHODS: We obtained the data of LSB, CS, IVDD, LBP, sciatica and proposed mediators from the gene-wide association studies (GWAS). The causal effects were examined by Inverse Variance Weighted (IVW) test, MR-Egger, weighted median, weighted mode and simple mode. And sensitivity analysis was performed using MR-Pleiotropy Residual Sum and Outlier (MR-PRESSO) and MR-Egger intercept test. Multivariable MR (MVMR) was conducted to investigate the independent factor of other LSB; while two-step MR analysis was used to explore the potential mediators including Body mass index (BMI), smoking initiation, type 2 diabetes mellitus (T2DM), major depressive disorder (MDD), schizophrenia, bipolar disorder between the causal association of LSB and these diseases based on previous studies. RESULTS: Genetically associated TV viewing was positively associated with the risk of CS (OR = 1.61, 95%CI = 1.25 to 2.07, p = 0.002), IVDD (OR = 2.10, 95%CI = 1.77 to 2.48, p = 3.79 x 10(-18)), LBP (OR = 1.84, 95%CI = 1.53 to 2.21, p = 1.04 x 10(-10)) and sciatica (OR = 1.82, 95% CI = 1.45 to 2.27, p = 1.42 x 10(-7)). While computer use was associated with a reduced risk of IVDD (OR = 0.66, 95%CI = 0.55 to 0.79, p = 8.06 x 10(-6)), LBP (OR = 0.49, 95%CI = 0.40 to 0.59, p = 2.68 x 10(-13)) and sciatica (OR = 0.58, 95%CI = 0.46 to 0.75, p = 1.98 x 10(-5)). Sensitivity analysis validated the robustness of MR outcomes. MVMR analysis showed that the causal effect of TV viewing on IVDD (OR = 1.59, 95%CI = 1.13 to 2.25, p = 0.008), LBP (OR = 2.15, 95%CI = 1.50 to 3.08, p = 3.38 x 10(-5)), and sciatica (OR = 1.61, 95%CI = 1.03 to 2.52, p = 0.037) was independent of other LSB. Furthermore, two-step MR analysis indicated that BMI, smoking initiation, T2DM may mediate the causal effect of TV viewing on these diseases. CONCLUSION: This study provides empirical evidence supporting a positive causal association between TV viewing and sciatica, IVDD and LBP, which were potentially mediated by BMI, smoking initiation and T2DM. CI - Copyright (c) 2024 Qiu, Wei, Tao, Song, Wang, Yin, Xie, Duan, Chen and Wang. FAU - Qiu, Youjia AU - Qiu Y AD - Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. FAU - Wei, Xingzhou AU - Wei X AD - Suzhou Medical School of Soochow University, Suzhou, Jiangsu, China. FAU - Tao, Yuchen AU - Tao Y AD - Suzhou Medical School of Soochow University, Suzhou, Jiangsu, China. FAU - Song, Bingyi AU - Song B AD - Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. FAU - Wang, Menghan AU - Wang M AD - Suzhou Medical School of Soochow University, Suzhou, Jiangsu, China. FAU - Yin, Ziqian AU - Yin Z AD - Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. FAU - Xie, Minjia AU - Xie M AD - Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. FAU - Duan, Aojie AU - Duan A AD - Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. FAU - Chen, Zhouqing AU - Chen Z AD - Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. FAU - Wang, Zhong AU - Wang Z AD - Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240123 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Intervertebral disc disease SB - IM MH - Humans MH - *Intervertebral Disc Degeneration MH - *Sciatica MH - *Low Back Pain MH - *Depressive Disorder, Major MH - *Diabetes Mellitus, Type 2 MH - Mendelian Randomization Analysis MH - *Spondylosis MH - Leisure Activities MH - *Intervertebral Disc MH - *Intervertebral Disc Displacement PMC - PMC10844448 OTO - NOTNLM OT - Mendelian randomization OT - cervical spondylosis OT - intervertebral disk disorders OT - leisure sedentary behavior OT - low back pain OT - sciatica COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/02/07 06:42 MHDA- 2024/02/08 06:42 PMCR- 2024/01/23 CRDT- 2024/02/07 03:55 PHST- 2023/08/28 00:00 [received] PHST- 2024/01/08 00:00 [accepted] PHST- 2024/02/08 06:42 [medline] PHST- 2024/02/07 06:42 [pubmed] PHST- 2024/02/07 03:55 [entrez] PHST- 2024/01/23 00:00 [pmc-release] AID - 10.3389/fpubh.2024.1284594 [doi] PST - epublish SO - Front Public Health. 2024 Jan 23;12:1284594. doi: 10.3389/fpubh.2024.1284594. eCollection 2024.