PMID- 38322452
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240210
IS  - 2307-8960 (Print)
IS  - 2307-8960 (Electronic)
IS  - 2307-8960 (Linking)
VI  - 12
IP  - 3
DP  - 2024 Jan 26
TI  - Primary anaplastic lymphoma kinase-positive large B-cell lymphoma of the left 
      bulbar conjunctiva: A case report.
PG  - 657-664
LID - 10.12998/wjcc.v12.i3.657 [doi]
AB  - BACKGROUND: Anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma 
      (LBCL) is an aggressive and rare variant of diffuse LBCL. Herein, we report an 
      uncommon case of stage IE extranodal ALK-positive LBCL initially originating in 
      the bulbar conjunctiva. CASE SUMMARY: A 63-year-old woman presented with a mass 
      in the left bulbar conjunctiva that had persisted for six months, accompanied by 
      swelling and pain that had persisted for 3 d. Eye examination revealed an 8 mm 
      slightly elevated pink mass in the lower conjunctival sac of the left eye. 
      Microscopically, the tumor was composed of large immunoblastic and plasmablastic 
      large lymphoid cells with scattered anaplastic or multinucleated large cells. 
      Immunophenotypically, the neoplastic cells were positive for ALK, CD10, CD138, 
      Kappa, MUM1, BOB.1, OCT-2, CD4, CD45, EMA, CD79a, CD38, and AE1/AE3, and negative 
      for CD20, PAX5, Lambda, BCL6, CD30 and all other T-cell antigens. The results of 
      gene rearrangement tests showed monoclonal IGH/IGK/IGL and TCRD rearrangements. 
      Fluorescence in situ hybridization studies did not reveal any BCL2, BCL6 or MYC 
      rearrangements. Furthermore, Epstein-Barr virus was not detected by in situ 
      hybridization in the lesions. Based on the histopathological and imaging 
      examinations, the neoplasm was classified as stage IE ALK-positive LBCL. No 
      further treatments were administered. At the 6, 15, and 21 mo postoperative 
      follow-up visits, the patient was in good condition, without obvious discomfort. 
      This case represents the first example of primary extranodal ALK-positive LBCL 
      presenting as a bulbar conjunctival mass, which is extremely rare and shares 
      morphological and immunohistochemical features with a variety of other neoplasms 
      that can result in misdiagnosis. CONCLUSION: Awareness of the condition presented 
      in this case report is necessary for early and accurate diagnosis and appropriate 
      treatment.
CI  - (c)The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Guo, Xiao-Hong
AU  - Guo XH
AD  - Department of Pathology, Zhuhai People's Hospital (Zhuhai Hospital Affiliated 
      with Jinan University), Zhuhai 519000, Guangdong Province, China.
FAU - Li, Chu-Bin
AU  - Li CB
AD  - Department of Pathology, Zhuhai People's Hospital (Zhuhai Hospital Affiliated 
      with Jinan University), Zhuhai 519000, Guangdong Province, China.
FAU - Cao, Hui-Hui
AU  - Cao HH
AD  - Department of Pathology, Zhuhai People's Hospital (Zhuhai Hospital Affiliated 
      with Jinan University), Zhuhai 519000, Guangdong Province, China.
FAU - Yang, Gen-Yuan
AU  - Yang GY
AD  - Endoscopy Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan 
      University), Zhuhai 519000, Guangdong Province, China. ygy19811104@163.com.
LA  - eng
PT  - Case Reports
PL  - United States
TA  - World J Clin Cases
JT  - World journal of clinical cases
JID - 101618806
PMC - PMC10841960
OTO - NOTNLM
OT  - Anaplastic lymphoma kinase
OT  - Case report
OT  - Conjunctiva
OT  - Immunoglobulin/T-cell receptor gene
OT  - Immunohistochemistry
OT  - Large B-cell lymphoma
COIS- Conflict-of-interest statement: The authors declare that they have no conflict of 
      interest to disclose.
EDAT- 2024/02/07 06:42
MHDA- 2024/02/07 06:43
PMCR- 2024/01/26
CRDT- 2024/02/07 04:01
PHST- 2023/11/18 00:00 [received]
PHST- 2023/12/17 00:00 [revised]
PHST- 2024/01/02 00:00 [accepted]
PHST- 2024/02/07 06:43 [medline]
PHST- 2024/02/07 06:42 [pubmed]
PHST- 2024/02/07 04:01 [entrez]
PHST- 2024/01/26 00:00 [pmc-release]
AID - 10.12998/wjcc.v12.i3.657 [doi]
PST - ppublish
SO  - World J Clin Cases. 2024 Jan 26;12(3):657-664. doi: 10.12998/wjcc.v12.i3.657.