PMID- 38322464
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240210
IS  - 2307-8960 (Print)
IS  - 2307-8960 (Electronic)
IS  - 2307-8960 (Linking)
VI  - 12
IP  - 3
DP  - 2024 Jan 26
TI  - Significance of oxidative stress and antioxidant capacity tests as biomarkers of 
      premature ovarian insufficiency: A case control study.
PG  - 479-487
LID - 10.12998/wjcc.v12.i3.479 [doi]
AB  - BACKGROUND: Premature ovarian insufficiency (POI) is a condition that causes 
      secondary amenorrhea owing to ovarian hypofunction at an early stage. Early 
      follicular depletion results in intractable infertility, thereby considerably 
      reducing the quality of life of females. Given the continuum in weakened ovarian 
      function, progressing from incipient ovarian failure (IOF) to transitional 
      ovarian failure and further to POI, it is necessary to develop biomarkers for 
      predicting POI. The oxidative stress states in IOF and POI were comprehensively 
      evaluated via oxidative stress [diacron-reactive oxygen metabolites (d-ROMs)] 
      test and antioxidant capacity [biological antioxidant potential (BAP)]. AIM: To 
      explore the possibilities of oxidative stress and antioxidant capacity as 
      biomarkers for the early detection of POI. METHODS: Females presenting with 
      secondary amenorrhea over 4 mo and a follicle stimulating hormone level of > 40 
      mIU/mL were categorized into the POI group. Females presenting with a normal 
      menstrual cycle and a follicle stimulating hormone level of > 10.2 mIU/mL were 
      categorized into the IOF group. Healthy females without ovarian hypofunction were 
      categorized into the control group. Among females aged < 40 years who visited our 
      hospital from January 2021 to June 2022, we recruited 11 patients into both POI 
      and IOF groups. For the potential antioxidant capacity, the relative oxidative 
      stress index (BAP/d-ROMs x 100) was calculated, and the oxidative stress defense 
      system was comprehensively evaluated. RESULTS: d-ROMs were significantly higher 
      in the POI and IOF groups than in the control group, (478.2 +/- 58.7 U.CARR, 434.5 
      +/- 60.6 U.CARR, and 341.1 +/- 35.1 U.CARR, respectively) (U.CARR is equivalent to 
      0.08 mg/dL of hydrogen peroxide). However, no significant difference was found 
      between the POI and IOF groups. Regarding BAP, no significant difference was 
      found between the control, IOF, and POI groups (2078.5 +/- 157.4 mumol/L, 2116.2 +/- 
      240.2 mumol/L, and 2029.0 +/- 186.4 mumol/L, respectively). The oxidative stress 
      index was significantly higher in the POI and IOF groups than in the control 
      group (23.7 +/- 3.3, 20.7 +/- 3.6, and 16.5 +/- 2.1, respectively). However, no 
      significant difference was found between the POI and IOF groups. CONCLUSION: High 
      levels of oxidative stress suggest that evaluating the oxidative stress state may 
      be a useful indicator for the early detection of POI.
CI  - (c)The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Kakinuma, Kaoru
AU  - Kakinuma K
AD  - Department of Obstetrics and Gynecology, International University of Health and 
      Welfare Hospital, Tochigi 329-2763, Japan.
AD  - Graduate School of Medicine, International University of Health and Welfare, 
      Tokyo 107-8402, Japan.
FAU - Kakinuma, Toshiyuki
AU  - Kakinuma T
AD  - Department of Obstetrics and Gynecology, International University of Health and 
      Welfare Hospital, Tochigi 329-2763, Japan. tokakinuma@gmail.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Clin Cases
JT  - World journal of clinical cases
JID - 101618806
PMC - PMC10841946
OTO - NOTNLM
OT  - Biological antioxidant potential
OT  - Biomarker
OT  - Diacron-reactive oxygen metabolites test
OT  - Infertility
OT  - Oxidative stress
OT  - Premature ovarian insufficiency
COIS- Conflict-of-interest statement: All the authors declare that they have no 
      conflicts of interest related to the manuscript.
EDAT- 2024/02/07 06:42
MHDA- 2024/02/07 06:43
PMCR- 2024/01/26
CRDT- 2024/02/07 04:01
PHST- 2023/08/25 00:00 [received]
PHST- 2023/11/27 00:00 [revised]
PHST- 2024/01/02 00:00 [accepted]
PHST- 2024/02/07 06:43 [medline]
PHST- 2024/02/07 06:42 [pubmed]
PHST- 2024/02/07 04:01 [entrez]
PHST- 2024/01/26 00:00 [pmc-release]
AID - 10.12998/wjcc.v12.i3.479 [doi]
PST - ppublish
SO  - World J Clin Cases. 2024 Jan 26;12(3):479-487. doi: 10.12998/wjcc.v12.i3.479.